Enhancement of Biofunctionalization by Loading Manuka Oil on TiO2 Nanotubes

Abstract

Metallic implants (mesh) for guided bone regeneration can result in foreign body reactions with surrounding tissues, infection, and inflammatory reactions caused by micro-organisms in the oral cavity after implantation. This study aimed to reduce the possibility of surgical failure caused by microbial infection by loading antibacterial manuka oil in a biocompatible nanostructure surface on Ti and to induce stable bone regeneration in the bone defect. The manuka oil from New Zealand consisted of a rich β-triketone chemotype, leptospermone, which showed strong inhibitory effects against several bacteria, even at very low oil concentrations. The TiO2 nanotubular layer formed by anodization effectively enhanced the surface hydrophilicity, bioactivity, and fast initial bone regeneration. A concentration of manuka oil in the range of 0.02% to less than 1% can have a synergistic effect on antibacterial activity and excellent biocompatibility. A manuka oil coating (especially with a concentration of 0.5%) on the TiO2 nanotube layer can be expected not only to prevent stenosis of the connective tissue around the mesh and inflammation by microbial infection but also to be effective in stable and rapid bone regeneration.

Antibacterial Activity and Biocompatibility with the Concentration of Ginger Fraction in Biodegradable Gelatin Methacryloyl (GelMA) Hydrogel Coating for Medical Implants

“…Recently, various studies have been conducted on the medical application of natural products [ 20 , 21 , 22 , 23 ]. In this study, to improve the functionality of dental implants using ginger (fraction) , the ginger was combined with pre-modification using TNC and the photo-crosslinkable GelMA hydrogel.…”

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

“…Bacterial infection in GBR membranes is another major problem, leading to complications in the procedure. The membrane is used to cover the bone defect and protect it from bacterial contamination, but if it becomes infected, it can impede the healing process and lead to potential failure. , The most common bacterial species that cause infection in GBR membranes are Streptococcus spp, Staphylococcus spp, and Porphyromonas gingivalis . , One common solution reported is to directly dope the membrane with antibiotics to minimize the risk of infection. , However, the uncontrollable continuous release of antibiotics was reported as the main drawback, hindering their real-world application as anti-infectious membranes.…”

“… 202 , 203 The most common bacterial species that cause infection in GBR membranes are Streptococcus spp, Staphylococcus spp, and Porphyromonas gingivalis . 204 , 205 One common solution reported is to directly dope the membrane with antibiotics to minimize the risk of infection. 206 , 207 However, the uncontrollable continuous release of antibiotics was reported as the main drawback, hindering their real-world application as anti-infectious membranes.…”

Evaluation of Photocatalytic, Antioxidant, and Antibacterial Efficacy of Almond Oil Capped Zinc Oxide Nanoparticles

“…Particularly, the functionalization of nanomaterials using vegetable oils is considered as effective technique [33]; still, these materials have been relatively less utilized. Among various vegetable oils, almond oil, which is widely extracted for various purposes including for use in food flavorings and the cosmetics industry [34], is a rich source of macronutrients and micronutrients.…”