Enhancement of antimicrobial activity of furazolidone and nitrofurantoin against clinical isolates of Enterobacteriaceae by piperitone

Shahverdi, A R; Rafii, Fatemeh; Fazeli, Mehdi; Jamalifar, Hossein

doi:10.1016/j.ijat.2004.04.007

Cited by 17 publications

(13 citation statements)

References 6 publications

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“…Other study showed that piperitone completely inhibited Aspergillus flavus at low concentrations (Cárdenas-Ortega et al 2005). Moreover, piperitone has increased the antimicrobial activity of furazolidone and nitrofurantoin against Enterobacteriaceae (Shahverdi et al 2004).…”

Section: Discussionmentioning

confidence: 92%

Anthelmintic effect of Mentha spp. essential oils on Echinococcus granulosus protoscoleces and metacestodes

et al. 2011

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The aim of the present work was to determine the in vitro effect of Mentha piperita and Mentha pulegium essential oils against Echinococcus granulosus and to compare the effectiveness of both oils according to the exposure time and concentration. Although both treatments had a protoscolicidal effect, M. pulegium had a considerably stronger effect than M. piperita. Essential oil of M. pulegium produced dose- and time-dependent effects. Maximal protoscolicidal effect was observed after 12 days of incubation and reached 0% after 18 days. This lack of viability was proved during the determination of infectivity into mice. Essential oil of M. piperita produced only a time-dependent effect. At 24 days p.i., the viability of protoscoleces decreased to approximately 50%. Scanning and transmission electron microscopy (SEM and TEM) demonstrated the drug-induced ultrastructural damage. On the other hand, a loss of turgidity was detected in all M. pulegium-treated cysts respective of the drug concentration. There was a correlation between the intensity of damage and the concentration of the essential oil assayed. Studies by SEM revealed that the germinal layer of treated cysts lost the feature multicellular structure. M. pulegium essential oil showed piperitone oxide as main compound in their composition, and we suggest that this component could be responsible of the markedly anthelmintic effect detected. Our data suggest that essential oils of Mentha spp. can be a promising source of potential protoscolicidal agents. The isolation of active anthelmintic constituents is in progress and may lead to the discovery of compounds with improved therapeutic value.

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Section: Discussionmentioning

confidence: 92%

Anthelmintic effect of Mentha spp. essential oils on Echinococcus granulosus protoscoleces and metacestodes

et al. 2011

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“…nent piperitone enhance bactericidal activities of nitrofurantoin and furazolidone against Enterobacteriaceae [15][16][17] . It is imperative that additional sources of similar compounds are found.…”

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confidence: 99%

Comparison of Essential Oils from Three Plants for Enhancement of Antimicrobial Activity of Nitrofurantoin against Enterobacteria

Rafii

Shahverdi

2006

Chemotherapy

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Background: Piperitone from plant essential oils enhancesbactericidal activities of nitrofurantoin and furazolidone against bacteria from the family Enterobacteriaceae. In this study, the essential oils of spearmint (Mentha spicata L.), dill (Anethum graveolens L.) and peppermint (Mentha piperita L.)were screened for augmentation of nitrofurantoin activity and the most active components were determined. Method: The effects of essential oils and their components on the bactericidal activity of nitrofurantoin against Enterobacter cloacae were studied using disk-diffusion and agar-dilution methods. The composition of essential oils was studied using gas chromatography-mass spectrometry. Results:M. spicata and A. graveolens oils exhibited the highest effects. Gas chromatography-mass spectrometry analysis showed that the oils of these two plants contained 40.12 and 20.32% carvone, respectively. Pure carvone and piperitone equally increased the bactericidal activity of nitrofurantoin. Other ingredients of essential oils, including camphor, limonene and menthone, were less effective.

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“…Recently, various natural products or synthetic compounds have been reported to increase the antibacterial activity of the presently used antibiotics against different clinical isolated resistant test strains [5][6][7][8][9][10][11][12][13]. The essential oil of Cinnamon zirconium has been reported to enhance the activity of clindamycin against toxicogenic Clostridium difficile [11].…”

Section: Discussionmentioning

confidence: 99%

“…Using resistance modulators with the antibiotics is one of the important alternatives, which deactivates the resistance mechanism of microorganisms and also extends the usefulness of antibiotics with known clinical, pharmacological, and toxicological properties [3,4]. Besides developing new chemical resistance inhibitors [5][6][7], plant-based natural products are being searched to work as resistance modulators [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Antifungal Activity of Sarcococca saligna Ethanol Extract and its Combination Effect with Fluconazole against Different Resistant Aspergillus Species

Mollazadeh-Moghaddam

Arfan

Rafique

et al. 2009

Appl Biochem Biotechnol

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Microbial resistance is a major drawback in chemotherapy of microbial or fungal infection disease. In this study, the antifungal activity of ethanol extract of a selected plant (Sarcococca saligna) has been investigated against clinical isolates of Aspergillus niger, Aspergillus treus, Aspergillus flavus, and Aspergillus fumigatus. Also, the enhancement of the antifungal activity of fluconazole by this extract was further evaluated against mentioned test strains. Conventional disk diffusion method was used to assay the antifungal activity of S. saligna ethanol extract in the absence and presence of fluconazole. The highest antifungal activity was observed against A. treus. The ethanol extract of S. saligna enhanced the antifungal activity of fluconazole against A. niger and A. treus and A. flavus. At the highest tested contents (4 mg/disk), 1.15-, 0.64-, and 2.47-fold increases in inhibition zone surface area were observed for A. niger, A. treus, and A. flavus, respectively. However, no enhancing effect was observed for this plant extract against Aspergillus fumigates at tested contents (0.5, 1, 2, 3, and 4 mg/disk). In a separate experiment, the general cytotoxicity of the ethanol extract of S. saligna was examined with brine shrimp assay. This plant extract showed low cytotoxicity against Artemia salina (LC(50) = 186 microg/ml).

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Enhancement of antimicrobial activity of furazolidone and nitrofurantoin against clinical isolates of Enterobacteriaceae by piperitone

Cited by 17 publications

References 6 publications

Anthelmintic effect of Mentha spp. essential oils on Echinococcus granulosus protoscoleces and metacestodes

Anthelmintic effect of Mentha spp. essential oils on Echinococcus granulosus protoscoleces and metacestodes

Comparison of Essential Oils from Three Plants for Enhancement of Antimicrobial Activity of Nitrofurantoin against Enterobacteria

The Antifungal Activity of Sarcococca saligna Ethanol Extract and its Combination Effect with Fluconazole against Different Resistant Aspergillus Species

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