Enhancement of Anticancer, Antibacterial, and Acetylcholinesterase Inhibition Activities from Oscillatoria sancta under Starvation Conditions

Touliabah, Hussein E.; Refaay, Dina A.

doi:10.3390/w15040664

Cited by 3 publications

(6 citation statements)

References 64 publications

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“…In another in vitro experiment, a crude methylene chloride/methanol (1:1) extract of Oscillatoria sancta lowered AChE activity by 60.7% [62]. The ethanolic extract of Nostoc sp.…”

Section: Cyanobacteria Against Alzheimer's Diseasementioning

confidence: 93%

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Ramos,

Reis,

Ferreira

et al. 2023

Biomolecules

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Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s Disease (HD). There are currently no available cures; there are only therapeutic approaches that ameliorate the progression of symptoms, which makes the search for new drugs and therapeutic targets a constant battle. Cyanobacteria are ancient prokaryotic oxygenic phototrophs whose long evolutionary history has resulted in the production of a plethora of biomedically relevant compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, that can be valuable in this field. This review summarizes the major NDs and their pathophysiology, with a focus on the anti-neurodegenerative properties of cyanobacterial compounds and their main effects.

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“…In another in vitro experiment, a crude methylene chloride/methanol (1:1) extract of Oscillatoria sancta lowered AChE activity by 60.7% [62]. The ethanolic extract of Nostoc sp.…”

Section: Cyanobacteria Against Alzheimer's Diseasementioning

confidence: 93%

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Ramos,

Reis,

Ferreira

et al. 2023

Biomolecules

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“…A study was conducted to assess the AChE inhibitory potential of the cyanobacterium Oscillatoria sancta . According to the obtained results, O. sancta extracts greatly reduced AChE activity, suggesting their potential use in treating Alzheimer’s disease [ 61 ]. One of the distinctive features of Alzheimer’s disease (AD) is the deposition of insoluble aggregates of amyloid β-peptide (Aβ) in the brain and its blood vessels [ 62 , 63 ].…”

Section: Bioactive Properties Reported From Marine Cyanobacteriamentioning

confidence: 99%

“…showed effective inhibition at a concentration of 100 μL [ 77 ]. The Oscillatoria sancta marine cyanobacterium was reported to show antibacterial activity against Bacillus cerus under starvation conditions [ 61 ].…”

Section: Bioactive Properties Reported From Marine Cyanobacteriamentioning

confidence: 99%

Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications

Perera

Herath

Sanjeewa

et al. 2023

Life

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The ocean is a valuable natural resource that contains numerous biologically active compounds with various bioactivities. The marine environment comprises unexplored sources that can be utilized to isolate novel compounds with bioactive properties. Marine cyanobacteria are an excellent source of bioactive compounds that have applications in human health, biofuel, cosmetics, and bioremediation. These cyanobacteria exhibit bioactive properties such as anti-inflammatory, anti-cancer, anti-bacterial, anti-parasitic, anti-diabetic, anti-viral, antioxidant, anti-aging, and anti-obesity effects, making them promising candidates for drug development. In recent decades, researchers have focused on isolating novel bioactive compounds from different marine cyanobacteria species for the development of therapeutics for various diseases that affect human health. This review provides an update on recent studies that explore the bioactive properties of marine cyanobacteria, with a particular focus on their potential use in human health applications.

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Section: Introductionmentioning

confidence: 99%

“…Alzheimer’s disease (AD) is a chronic and irreversible dementia marked by neurofibrillary tangles and widespread neuronal death [ 1 ]. This neurodegenerative disease often begins with minor memory loss and may progress to cognitive deficits, serious behavior issues, or mortality [ 1 ]. The development and precise origins of Alzheimer’s disease are still largely unclear; however, the most often advanced arguments include amyloid, metal, and cholinergic activity [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Cholinergic Effects of the Phenolic Extract from the Astragalus crenatus Plant: A Computational and Network Pharmacology Study

Lekmine,

Benslama,

Tahraoui

et al. 2024

Pharmaceuticals

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Investigations into cholinesterase inhibition have received attention from researchers in recent years for the treatment of Alzheimer’s disease. Cholinesterase enzymes, namely, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), hold pivotal significance in Alzheimer’s disease (AD) treatment. In this study, we utilized the ethanolic extract of Astragalus crenatus followed by liquid chromatography–electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to separate and identify at least 21 compounds in the extract. Rosmarinic acid exhibited the highest concentration (96.675 ± 1.3 mg/g extract), succeeded by hesperidin (79.613 ± 1.2 mg/g extract), hesperetin (75.102 ± 1.4 mg/g extract), rutin (68.156 ± 1.6 mg/g extract), chlorogenic acid (67.645 ± 1.5 mg/g extract), fisetin (66.647 ± 2.3 mg/g extract), and hyperoside (63.173 ± 1.5 mg/g extract). A. crenatus extract efficiently inhibited both AChE and BChE activities in a dosage-dependent manner. Molecular docking was employed to scrutinize the anticholinesterase mechanisms of the identified phytocompounds. Notably, a network pharmacology analysis was executed for the most efficacious compound. Based on binding energies, hesperidin emerged as the most potent inhibitor against both AChE and BChE, exhibiting scores of −10.5 Kcal/mol and −9.8 Kcal/mol, respectively. Due to its dual inhibition of AChE and BChE activities, hesperidin from Astragalus crenatus holds promise for the development of novel therapeutics aimed at neurological disorders, particularly AD.

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Enhancement of Anticancer, Antibacterial, and Acetylcholinesterase Inhibition Activities from Oscillatoria sancta under Starvation Conditions

Cited by 3 publications

References 64 publications

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications

Anti-Cholinergic Effects of the Phenolic Extract from the Astragalus crenatus Plant: A Computational and Network Pharmacology Study

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