Enhancement of Antibody Production and Protection Against Systemic Anaphylaxis by Large Doses of Vitamin C

Vitamin C in Disease Prevention and Cure: An Overview

“…Another study supports the fact that vitamin C acts with other micronutrients synergistically and enhances skin barrier function as well as protective activities of immune cells but its role in antibody protection is not as pronounced [180]. On the contrary animal studies support the role of supplementation of vitamin C in humoral immunity as it increases serum levels of antibodies [181] and C1q complement proteins [182] in guinea pigs, which cannot synthesize vitamin C like humans and hence depend on dietary supplementation. Vitamin C along with other micronutrients help in reverting potential damage caused by free radicals at cellular level and modulates immune cell functions through regulation of redox-sensitive transcription factors and affects production of cytokines and prostaglandins.…”

Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis

“…In addition to diminish the infiltration and activation of monocytes/macrophages, microglial cells, and PMNs, reducing inflammatory events in CNS (Libbey et al, 2011), MIN is capable of improving the humoral immune response in rats and mice (Reeta et al, 2002). Controversial reports regarding to the effect of AA on antibody production have been published; however, guinea pigs receiving 100 and 280 mg/day of AA throughout the duration of immunization showed enhanced humoral antibody production to bovine serum albumin (Feigen et al, 1982). These data suggest that increased levels of antibodies anti-VEE virus observed in survived mice, could be in part related to the effect of MLT, MIN or AA treatments.…”

Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation

“…Longterm treatment of Vitamin C increased serum IgA and IgM, but not IgG levels in humans [45]. In guinea pigs, Vitamin C administration during immunization enhanced specific humoral responses [46]. Many others have reported unaltered humoral responses in Balb/c mice [8], humans [47], and in guinea pigs [48].…”