Enhancement by adrenaline of ginsenoside Rg1 transport in Caco-2 cells and oral absorption in rats

Abstract

Adrenaline is effective for the stimulation of intestinal absorption of Rg1 and the enhanced absorption is mediated mainly by the interaction of adrenaline with beta2-adrenoceptors.

Active absorption of ginsenoside Rg1 in vitro and in vivo: the role of sodium-dependent glucose co-transporter 1

“…Since glucose is actively absorbed by sodium‐dependent glucose cotransporter 1 (SGLT1) in the brush‐border membrane (BBM) of intestinal epithelial cells, 10–12 SGLT1 may also be involved in the transport of some sugar analogues. In addition, our results obtained in another study 13 suggested that adrenaline (epinephrine) could be an effective absorption enhancer for Rg1 both in vivo and in vitro and that the enhancement is mediated by the interaction of adrenaline with β 2 ‐adrenoceptors. Adrenaline has been reported to have a stimulatory effect on glucose transport in the rat small intestine by regulating SGLT1 14 .…”

“…In our previous study, we demonstrated that the incubation of Caco‐2 cells with adrenaline resulted in a significant increase in the uptake and amount transported of Rg1 13 . Studies have demonstrated that adrenaline could increase the amount of SGLT1 in the BBM of intestinal epithelial cells by interacting with β‐adrenoceptors 24 .…”

Pharmacology of ginsenosides: a literature review

“…Experiments to increase the bioavailability of ginsenosides include co-administration of ginsenosides with adrenaline [86], emulsification of ginsenosides into lipid-based formulation [87,88] and suppression of p-glycoprotein efflux system [77]. P-glycoprotein-mediated multidrug resistance is a major obstacle to effective cancer treatments.…”

Active absorption of ginsenoside Rg1 <I>in vitro</I> and <I>in vivo</I>: the role of sodium-dependent glucose co-transporter 1

“…Since glucose is actively absorbed by sodium-dependent glucose cotransporter 1 (SGLT1) in the brush-border membrane (BBM) of intestinal epithelial cells, [10][11][12] SGLT1 may also be involved in the transport of some sugar analogues. In addition, our results obtained in another study [13] suggested that adrenaline (epinephrine) could be an effective absorption enhancer for Rg1 both in vivo and in vitro and that the enhancement is mediated by the interaction of adrenaline with b 2 -adrenoceptors. Adrenaline has been reported to have a stimulatory effect on glucose transport in the rat small intestine by regulating SGLT1.…”