Enhanced wound contraction in fresh wounds dressed with honey in wistar rats (&lt;i&gt;Rattus novergicus&lt;/i&gt;)

Osuagwu, Ferdnand C; Oladejo, O W; Imosemi, I. O.; Aiku, A; Ekpos, O E; Salami, Ayodeji; Oyedele, O O; Akang, EE

doi:10.4314/wajm.v23i2.28100

Cited by 20 publications

(21 citation statements)

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“…We believe that the increase in the wound reduction rate in the treated groups was caused by an increase in wound contraction caused by honey and the use of the scaffolding material pectin. The use of both materials allowed for the establishment of an ideal environment for healing, as demonstrated in previous studies [8, 9, 18, 20, 21]. The same factors may have caused the reduction in inflammation (compared with controls) found in the treatments groups.…”

Section: Discussionmentioning

confidence: 69%

A new, easy-to-make pectin-honey hydrogel enhances wound healing in rats

Giusto

Vercelli

Comino

et al. 2017

BMC Complement Altern Med

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BackgroundHoney, alone or in combination, has been used for wound healing since ancient times and has reemerged as a topic of interest in the last decade. Pectin has recently been investigated for its use in various biomedical applications such as drug delivery, skin protection, and scaffolding for cells. The aim of the present study was to develop and evaluate a pectin-honey hydrogel (PHH) as a wound healing membrane and to compare this dressing to liquid honey.MethodsThirty-six adult male Sprague-Dawley rats were anesthetized and a 2 × 2 cm excisional wound was created on the dorsum. Animals were randomly assigned to four groups (PHH, LH, Pec, and C): in the PHH group, the pectin-honey hydrogel was applied under a bandage on the wound; in the LH group, liquid Manuka honey was applied; in the Pec group, pectin hydrogel was applied (Pec); and in the C group, only bandage was applied to the wound. Images of the wound were taken at defined time points, and the wound area reduction rate was calculated and compared between groups.ResultsThe wound area reduction rate was faster in the PHH, LH, and Pec groups compared to the control group and was significantly faster in the PHH group. Surprisingly, the Pec group exhibited faster wound healing than the LH group, but this effect was not statistically significant.ConclusionThis is the first study using pectin in combination with honey to produce biomedical hydrogels for wound treatment. The results indicate that the use of PHH is effective for promoting and accelerating wound healing.

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Section: Discussionmentioning

confidence: 69%

A new, easy-to-make pectin-honey hydrogel enhances wound healing in rats

Giusto

Vercelli

Comino

et al. 2017

BMC Complement Altern Med

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“…Furthermore, honey has been shown to decrease free oxygen radicals and increase tumour necrosis factor-a to a significant level [17]. The application of honey into a newly formed wound increases wound contraction and accelerates wound healing [18]. Honey is constituted of mono and disaccharides such as fructose, glucose and maltose, hydrogen peroxide, enzymes, growth factors, tissue nourishing minerals and vitamins.…”

Section: Discussionmentioning

confidence: 99%

Intraurethral honey application for urethral injury: an experimental study

et al. 2006

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“…93 Several studies have reported the great potential of this bee product for wound healing: either applied alone 94,95 on rat wounds or in association with other natural products ( Aloe vera and milk or ascorbic acid), tested on burns in guinea pig and second-degree burns in rats, 96,97 as chitosan nanofiber wound dressing enriched with Allium sativum and Cleome droserifolia applied on mice’s wounds. 98 …”

Section: Immunomodulatory Activity Of Honey In Wound Healingmentioning

confidence: 99%

Honey as a Complementary Medicine

Miguel

Antunes

Faleiro

2017

Integr Med�Insights

127

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The beneficial effects of honey on human health have long been recognized. Today, many of those positive effects have been studied to elucidate its mode of action. This review briefly summarizes the best studied features of honey, highlighting it as an appealing alternative medicine. In these reports, the health benefits of honey range from antioxidant, immunomodulatory, and anti-inflammatory activity to anticancer action, metabolic and cardiovascular benefits, prebiotic properties, human pathogen control, and antiviral activity. These studies also support that the honey’s biological activity is mainly dependent on its floral or geographic origin. In addition, some promising synergies between honey and antibiotics have been found, as well as some antiviral properties that require further investigation. Altogether, these studies show that honey is effectively a nutraceutical foodstuff.

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Enhanced wound contraction in fresh wounds dressed with honey in wistar rats (<i>Rattus novergicus</i>)

Cited by 20 publications

References 0 publications

A new, easy-to-make pectin-honey hydrogel enhances wound healing in rats

A new, easy-to-make pectin-honey hydrogel enhances wound healing in rats

Intraurethral honey application for urethral injury: an experimental study

Honey as a Complementary Medicine

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