Intraurethral honey application for urethral injury: an experimental study

Ayyıldız, Ali; Akgül, K. Turgay; Cebeci, Özden; Nuhoğlu, Barış; Çaydere, Muzaffer; Üstün, Hüseyin; Germíyanoğlu, Cankon

doi:10.1007/s11255-006-9152-z

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Honey is easy to apply, helpful in cleaning the wounds, and without side effects Reduces pain [66,84,92] Molan [63] published a review article that covered the various reports that have been published on the clinical usage of honey. Positive findings on honey in wound care have been reported from 17 randomized controlled trials (1965 patients) and five clinical trials of other forms (97 patients) treated with honey.…”

Section: Type Of Lesion Effects Of Honeymentioning

confidence: 99%

“…Another study was performed to evaluate the effect of honey applied intraurethrally after urethral injury on histopathological healing in male rats. Results showed that intraurethral honey, applied after urethral injury, prevents inflammation and accelerates urethral healing [66]. A study has shown that intraperitoneal honey administration reduces postoperative peritoneal adhesion; the wound healing accelerative effect and the mechanical barrier formed by the honey was explained to be the reasons for its inhibitory effect on the adhesion [44].…”

Section: Type Of Lesion Effects Of Honeymentioning

confidence: 99%

“…Honey has antibacterial activity and, consequently, it is effective in treating infected wounds [43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,76,77,132,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150]. Clinical studies on the use of honey as a dressing for infected wounds report that the wounds become sterilize...…”

Section: Honey and Wound Dressingmentioning

confidence: 99%

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Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice

Al-Waili

Salom²,

Al-Ghamdi

2011

The Scientific World JOURNAL

244

193

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The widespread existence of unhealed wounds, ulcers, and burns has a great impact on public health and economy. Many interventions, including new medications and technologies, are being used to help achieve significant wound healing and to eliminate infections. Therefore, to find an intervention that has both therapeutic effect on the healing process and the ability to kill microbes is of great value. Honey is a natural product that has been recently introduced in modern medical practice. Honey's antibacterial properties and its effects on wound healing have been thoroughly investigated. Laboratory studies and clinical trials have shown that honey is an effective broad-spectrum antibacterial agent. This paper reviews data that support the effectiveness of natural honey in wound healing and its ability to sterilize infected wounds. Studies on the therapeutic effects of honey collected in different geographical areas on skin wounds, skin and gastric ulcers, and burns are reviewed and mechanisms of action are discussed. (Ulcers and burns are included as an example of challenging wounds.) The data show that the wound healing properties of honey include stimulation of tissue growth, enhanced epithelialization, and minimized scar formation. These effects are ascribed to honey's acidity, hydrogen peroxide content, osmotic effect, nutritional and antioxidant contents, stimulation of immunity, and to unidentified compounds. Prostaglandins and nitric oxide play a major role in inflammation, microbial killing, and the healing process. Honey was found to lower prostaglandin levels and elevate nitric oxide end products. These properties might help to explain some biological and therapeutic properties of honey, particularly as an antibacterial agent or wound healer. The data presented here demonstrate that honeys from different geographical areas have considerable therapeutic effects on chronic wounds, ulcers, and burns. The results encourage the use of honey in clinical practice as a natural and safe wound healer.

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Section: Type Of Lesion Effects Of Honeymentioning

confidence: 99%

Section: Type Of Lesion Effects Of Honeymentioning

confidence: 99%

Section: Honey and Wound Dressingmentioning

confidence: 99%

See 1 more Smart Citation

Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice

Al-Waili

Salom²,

Al-Ghamdi

2011

The Scientific World JOURNAL

244

193

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“…Daily application of a lubricating honey solution caused an improvement in urethral coverage, healing and narrowing after 21 days [ 27 ]. The use of dexpanthenol as catheter lubricant caused a decrease in urethral fibrosis in case of high dose treatment and a decrease in inflammation in both low and high dosage groups [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

The use of local therapy in preventing urethral strictures: A systematic review

et al. 2021

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Background Urethral stricture disease is a common problem amongst men in Western countries often leading to a decreased quality of life. Current endoscopic treatment procedure shows an unsatisfying stricture recurrence rate which could be improved by addition of local therapies. Objectives To provide an overview of both preclinical and clinical studies in order to investigate current level of evidence on the addition of local therapy to improve urethral stricture recurrence rates after endoscopic procedures. Methods We performed a literature search in December 2020 and August 2021 using Cochrane, Embase, PubMed, Scopus and Web of Science and identified articles through combinations of search terms for ‘urethral stricture disease’, ‘stricture formation’ and ‘local interventions’. We used the SYRCLE, RoB-2 and ROBINS-I tools to assess risk of bias across included studies. We did not perform a meta-analysis due to methodological differences between studies. Results We included 32 articles in the qualitative analysis, 20 of which were preclinical studies and 12 clinical studies. Regarding preclinical articles using an animal model, nearly all interventions showed to have a positive effect on either urethral fibrosis, urethral stricture formation and/or fibrotic protein expression levels. Here, immunosuppressants and chemotherapeutics seemed most promising for possible clinical purposes. Regarding clinical studies, mitomycin-C and hyaluronic acid and carboxymethylcellulose showed positive effects on urethral stricture recurrence rates with low to intermediate risk of bias across studies. However, the positive clinical effects of mitomycin-C and steroids seemed to decrease in studies with a longer follow-up time. Conclusion Although local adjuvant use of mitomycin-C or hyaluronic acid and carboxymethylcellulose may carry clinical potential to improve urethral structure recurrence rates after endoscopic procedures, we believe that a large, well-designed RCT with a yearlong follow-up time is necessary to identify the true clinical value.

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“…The rats were anaesthetized with a combination of ketamine-xylazine intraperitoneally before experiment. Urethral injury was created with the method previously described by Ayyıldız et al (10). The control group was not intervened.…”

Section: Creation Of Urethral Injury In Rats and Materials Collectionmentioning

confidence: 99%

Evaluation of oxidative stress in bladder in urethral injuries: an experimental model in rats

Öğüş

Ayyıldız

Keseroğlu

et al. 2020

Revista Romana De Medicina De Laborator

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Background: The aim of this study is to determine the changes of some oxidative stress parameters following an experimental urethral injury.Materials and Methods: 24 Wistar-Albino male rats were used and 18 of them were exposed to urethral injury. Total oxidant status (TOS) and total antioxidant capacity (TAC) values in bladder and penile tissues and sera of rats during creation and healing stages of injury (control, day-1, 7 and 21) were examined and evaluated histopathologically.Results: TOS levels in both tissue and serum groups increased nearly 4x fold in first day following injury. On the seventh day, TOS levels of bladder and penile tissue showed a nearly 50% decrease according to first day (p=0.005; p=0.025, respectively). At the end of third week, while bladder TOS levels decreased to control values, penile tissue TOS levels remained at high levels. The bladder TAC values mildly increased in first day (p=0.026) and then returned to normal levels in seventh day and continued to decrease down by half of control levels at the end of third week (p=0.005). TAC levels of penile tissue increased twofold in first day (p=0.021) and remained at same high levels for three weeks.Conclusion: We observed that first day after traumatic urethral injury seems to be very important for evaluation of traumatic injuries and wound healing. We believe when an urethral injury was occured, both urethra and bladder should be handled with care and without delay during urethral healing, because of the presence of oxidative changes in bladder.

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Intraurethral honey application for urethral injury: an experimental study

Abstract: Intraurethral honey, applied after urethral injury, prevents inflammation, accelerates urethral healing and provides perfect healing.

Cited by 8 publications

References 18 publications

Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice

Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice

The use of local therapy in preventing urethral strictures: A systematic review

Evaluation of oxidative stress in bladder in urethral injuries: an experimental model in rats

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