Enhanced Two-Photon Fluorescence Imaging and Therapy of Cancer Cells via Gold@Bridged Silsesquioxane Nanoparticles

Croissant, Jonas G.; Maynadier, Marie; Mongin, Olivier; Hugues, Vincent; Blanchard‐Desce, Mireille; Chaix, Arnaud; Cattoën, Xavier; Man, Michel Wong Chi; Gallud, Audrey; Gary‐Bobo, Magali; Garcia, Marcel; Raehm, Laurence; Durand, Jean‐Olivier

doi:10.1002/smll.201401759

Cited by 61 publications

(68 citation statements)

References 30 publications

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“…Durand and co-workers introduced grafted chromophores directly in the silica nanoparticles and either incorporated Au NPs in the core or grafting them at the surface of the fluorescent silica (Figure 40). [465] Comparison between the different systems showed that the introduction of the Au NPs provided Figure 39. Synthesis of a photosensitizer doped silica shell on gold nanorods.…”

Section: Q16mentioning

confidence: 99%

“…[454] Among the most investigated strategies is the use of core shell nanostructures with metal core and silica based shell, which provides also a good possibility of spacing control between the dyes and the metallic surface. [455][456][457][458][459][460][461][462][463][464][465] The dye can be either directly incorporated in the silica shell during the synthesis of post-grafted at the surface of the silica. M. A. Noginov used this configuration to generate core-shell structure functionalized at the surface by Oregon green 488 fluorophore encapsulated in the outer silica shell.…”

Section: Q16mentioning

confidence: 99%

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Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Parola

Julián‐López

Carlos

et al. 2016

Adv Funct Materials

223

110

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Research on hybrid inorganic‐organic materials has experienced an explosive growth since the 1980s, with the expansion of soft inorganic chemistry based processes. Indeed, mild synthetic conditions, low processing temperatures provided by “chimie douce” and the versatility of the colloidal state allow for the mixing of the organic and inorganic components at the nanometer scale in virtually any ratio to produce the so called hybrid materials. Today a high degree of control over both composition and nanostructure of these hybrids can be achieved allowing tunable structure‐property relationships. This, in turn, makes it possible to tailor and fine‐tune many properties (mechanical, optical, electronic, thermal, chemical…) in very broad ranges, and to design specific multifunctional systems for applications. In particular, the field of “Hybrid‐Optics” has been very productive not only scientifically but also in terms of applications. Indeed, numerous optical devices based on hybrids are already in, or very close, to the market. This review describes most of the recent advances performed in this field. Emphasis will be given to luminescent, photochromic, NLO and plasmonic properties. As an outlook we show that the controlled coupling between plasmonics and luminescence is opening a land of opportunities in the field of “Hybrid‐Optics”.

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Section: Q16mentioning

confidence: 99%

Section: Q16mentioning

confidence: 99%

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Parola

Julián‐López

Carlos

et al. 2016

Adv Funct Materials

223

110

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8][9] Nonetheless, it remains a challenge to control the kinetic in sol-gel processes, which generally lead to macroscaled nonporous BS functional materials. [10][11][12] Their design involves kinetically-controlled sol-gel processes of bis-or multiorganoalkoxysilanes which yield to hybrid materials with very high organic contents depending on the type of organic groups.…”

Section: Abstract: Bridged Silsesquioxane Dna Delivery Organosilicamentioning

confidence: 99%

Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Fatieiev

Croissant

Alsaiari

et al. 2015

ACS Appl. Mater. Interfaces

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Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene−ammonium bridges are described. The systematic screening of the sol−gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100−200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to −39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

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“…Additionally, cancer cells can become drug resistant after a prolonged treatement with a given drug. [5] As a result, the so-called nanomedicine has been an extensive research area aiming to design nanomaterials which could transport and deliver drugs, or other therapeutic agents, [6] selectively into tumors in order to decrease and preclude the side effects of chemotherapy, to decrease the dosage of drugs, and potentially transport several drugs to harness synergistic effects. [7,8] Drug delivery nanosystems capable of transporting multiple drugs are emerging for the treatment of cancers.…”

Section: Introductionmentioning

confidence: 99%

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

Croissant¹,

Zhang

Alsaiari

et al. 2016

Journal of Controlled Release

150

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, Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging, Journal of Controlled Release (2016Release ( ), doi: 10.1016Release ( /j.jconrel.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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Enhanced Two-Photon Fluorescence Imaging and Therapy of Cancer Cells via Gold@Bridged Silsesquioxane Nanoparticles

Cited by 61 publications

References 30 publications

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

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