Enhanced tumor cell killing by ultrasound after microtubule depolymerization

Abstract

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Magnetic particles for triggering insulin release in INS-1E cells subjected to a rotating magnetic field

“…Indeed, these channels have been shown to be activated by distinct mechanical stimuli, all of them inducing plasma membrane deformations, including membrane stretch due to hypotonic treatment, shear stress, hydrostatic pressure, compression, ultrasound or piezoelectric microvibration. 27,[29][30][31][32][33] This would allow the release of insulin, which could therefore contribute to the treatment of diabetes. Still, in contrast to all the other sources of the mechanical stimulation of pancreatic β-cells that have been described so far, the magneto-mechanical treatment proposed here can be finely tuned to be delivered to β-cells only, because Fe 20 Ni 80 particles can be easily functionalized to promote targeted delivery.…”

Rejuvenation of Senescent Cells, in vitro and in vivo, by Low-frequency Ultrasound without Senolysis

“…The cells were treated with LFU and imaged again at the same confocal microscope settings. Length of myotubules was determined as described previously (Singh et al 2021).…”

Towards an integrative understanding of cancer mechanobiology: calcium, YAP, and microRNA under biophysical forces

“…14–16,19–29 Advances in the understanding of mechanotransduction have led to the design and development of new classes of pharmaceuticals, drug testing and delivery systems, wearable therapeutic devices, and engineered tissues that leverage biomechanics or target mechanobiology pathways to enable innovative combinatorial therapeutics. 30–39…”