Magnetic particles for triggering insulin release in INS-1E cells subjected to a rotating magnetic field

Ponomareva, Svetlana; Joisten, Hélène; Francois, Taina; Naud, Cécile; Morel, R.; Hou, Yanxia; Myers, Thomas O.; Joumard, Isabelle; Diény, B.; Carrière, Marie

doi:10.1039/d2nr02009b

Cited by 3 publications

(22 citation statements)

References 35 publications

(52 reference statements)

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“…For biological applications, the membrane can also constitute the bottom of a container filled with a fluid. [ 34 ] In this case, the deformation of the membrane results both from the magnetic field and from the fluid weight (hydrostatic pressure). The array of permalloy microdisks was prepared by deep ultraviolet (DUV) photolithography.…”

Section: Resultsmentioning

confidence: 99%

“…Our PDMS‐based membranes were strong and waterproof enough to form the bottom of containers holding aqueous solutions such as water or cell culture medium. [ 34 ] As non‐treated PDMS exhibits hydrophobic properties, a surface treatment by O 2 plasma was applied to render its surface hydrophilic. [ 39 ] The PDMS membranes mechanical properties were characterized under hydrostatic pressure, as shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…In our experimental work, the MEMs were subjected to external magnetic fields generated by NdFeB permanent magnets of two different strengths μ 0 M MAG = 1.29 or 1.36 T, respectively, in the optical setup and in the bioreactor used to stimulate pancreatic cells described later and in more details in another study. [ 34 ] Their magnetization M MAG , considered uniform, is parallel to the Z ‐axis. The magnets are parallelepipeds of dimensions (2 a × 2 b ) × h parallel to the X ‐, Y ‐, and Z ‐axes (5 mm × 20 mm) × 20 mm in both experimental cases.…”

Section: Resultsmentioning

confidence: 99%

“…In an initial experiment, we showed that the vibration of such a membrane, triggered via a rotating magnetic field of a few tens of Hz, efficiently induced insulin secretion from live pancreatic cells grown on the membrane surface (Ponomareva et al). [ 34 ]…”

Section: Introductionmentioning

confidence: 99%

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Microstructured Magnetoelastic Membrane for Magnetic Bioactuators and Soft Artificial Muscles Applications

Ponomareva

Carrière

Hou

et al. 2023

Advanced Intelligent Systems

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In the growing field of mechanobiology, artificial mechano‐reactive systems play an essential role in the generation of mechanical forces and control of material deformations. Free‐standing magnetic nanoparticles have been studied for the mechanical stimulation of living cells. Magnetic composite materials are also used to mimic muscles at macroscale. In this study, a new magnetically actuated membrane is focused, which can be used for various applications in soft robotics or as a bioreactor. It consists of a few microns thick polydimethylsiloxane (PDMS) membrane in which an array of magnetic microdisks is embedded. These membranes have a large tuneable flexibility, and they are transparent, biocompatible, and waterproof. They are usable in biology and optics, both potentially combined. The membrane deformations under magnetic field have been experimentally characterized and modeled. By growing pancreatic cells on such membranes, it has been demonstrated that insulin production from the cells can be enhanced thanks to the mechanical stimulation of the cells provided by the actuated membrane.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microstructured Magnetoelastic Membrane for Magnetic Bioactuators and Soft Artificial Muscles Applications

Ponomareva

Carrière

Hou

et al. 2023

Advanced Intelligent Systems

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“…However, the long-term increase of free fatty acids represented by PA leads to the apoptosis of pancreatic β-cells. As a result, the function of insulin secretion is reduced [ 44 , 45 , 46 ]. Therefore, pancreatic β-cell retention may be an effective strategy to prevent diabetes.…”

Section: Discussionmentioning

confidence: 99%

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

et al. 2023

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Oxidative stress damage of pancreatic β-cells is a key link in the pathogenesis of type 2 diabetes mellitus. A long-term increase of free fatty acids induces the increase of reactive oxygen species (ROS) in β-cells, leading to apoptosis and dysfunction of β-cells. Ganoderma lucidum spore oil (GLSO) is a functional food complex with strong antioxidant activity, but its solubility and stability are poor. In the present study, GLSO-functionalized selenium nanoparticles (GLSO@SeNPs) with high stability and uniform particle size were synthesized by a high-pressure homogeneous emulsification method. The aim of this study was to investigate the protective effects of GLSO@SeNPs on INS-1E rat insulinoma β-cells against palmitic-acid (PA)-induced cell death, as well as the underlying mechanisms. Our results showed that GLSO@SeNPs had good stability and biocompatibility, and they significantly inhibited the PA-induced apoptosis of INS-1E pancreatic cells by regulating the activity of related antioxidant enzymes, including thioredoxin reductase (TrxR), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Western blot analysis showed that GLSO@SeNPs reversed the PA-induced changes in MAPK pathway protein expression levels. Thus, the present findings provided a new theoretical basis for utilizing GLSO@SeNPs as a treatment for type 2 diabetes.

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Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery

Moorthy

Thirupathi²,

Selvakumar³

et al. 2023

Magnetochemistry

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In clinical applications for cancer treatment, chemotherapy coupled with thermotherapy is highly considered. The development of multifunctional nanocomposite materials is an appealing strategy for use in various applications including biomedical applications. We present the preparation of dopamine-modified mesoporous silica material, in which magnetic iron oxide nanoparticles (FeNP) were grown onto the outer surface via the complexation of iron (Fe(III) and Fe(II)) ions with the dopamine groups modified on the silica hybrid and subsequent chemical reduction approaches. The prepared magnetic iron oxide incorporated with mesoporous silica hybrid composite nanoparticles (FeNP@MSHC NPs) had a large surface area (346 m2/g), pore size (3.2 nm), and pore volume (0.048 cm3/g). The formation of FeNP on the outer surface of the FeNP@MSHC NPs results in superparamagnetic characteristics. Furthermore, the prepared FeNP@MSHC NPs have a high drug (Dox) loading capacity (~62%) as well as pH- and temperature-responsive drug release efficiency. In addition, the MTT assay result shows the biocompatibility of the prepared FeNP@MSHC NPs. As a result, the FeNP@MSHC NPs could be utilized in cancer treatment for pH and temperature-sensitive delivery of chemotherapeutic agents to the target sites.

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Magnetic particles for triggering insulin release in INS-1E cells subjected to a rotating magnetic field

Abstract: Diabetes is a major global health threat. Both academics and industry are striving to develop effective treatments for this disease. In this work, we present a new approach to induce...

Cited by 3 publications

References 35 publications

Microstructured Magnetoelastic Membrane for Magnetic Bioactuators and Soft Artificial Muscles Applications

Microstructured Magnetoelastic Membrane for Magnetic Bioactuators and Soft Artificial Muscles Applications

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery

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