Enhanced transdermal delivery of luteolin via non-ionic surfactant-based vesicle: quality evaluation and anti-arthritic assessment

Abidin, Lubna; Mujeeb, Mohammed; Imam, Syed Sarim; Aqil, Mohammad; Khurana, Deepak

doi:10.3109/10717544.2014.945130

Cited by 53 publications

(28 citation statements)

References 27 publications

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“…(Ballinger et al, 1996;Magee et al, 2003;Cheng et al, 2014), Compared with the ion surfactant, the non-ionic surfactant has high stability and will not be easily disassembled by strong electrolyte or acid-base. In addition, it has the compatibility with most drugs but less toxicity and hemolysis (Wachter et al, 2008;Abidin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15

et al. 2015

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Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with lecithin and Solutol HS 15 (BLSM) has been performed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small cell lung cancer (NSCLC) A549 cells.Results showed that the obtained micelles have a mean particle size of around 62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BLSM displayed a more potent antiproliferative action on A549 cell lines than baohuoside I; halfmaximal inhibitory concentration (IC 50 ) was 6.31 versus 18.28 mg/mL, respectively. The antitumor efficacy test in nude mice showed that BLSM exhibited significantly higher antitumor activity against NSCLC with lesser toxic effects on normal tissues. The imaging study for in vivo targeting demonstrated that the mixed micelles formulation achieved effective and targeted drug delivery. Therefore, BLSM might be a potential antitumor formulation.

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Section: Introductionmentioning

confidence: 99%

Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15

et al. 2015

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“…In such a study, the gel mediated delivery of luteolin has been reported to be highly effective in arthritis management. [13] Proniosomes have also been widely reported in the treatment of various skin diseases via efficient and effective topical delivery of drugs. Sandeep et al demonstrated the high permeation and prolonged release of fluconazole via topical proniosomal gel mediated delivery.…”

Section: Introductionmentioning

confidence: 99%

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Lather¹,

Sharma²,

Pandita³

2016

Journal of Experimental Nanoscience

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Vesicular systems endow large opportunities for the transdermal delivery of therapeutics. The present study was designed to investigate the potential of a novel class of vesicular system 'proniosome' as a carrier for transdermal delivery of bromocriptine (BCT). Proniosome formulations were prepared by the coacervationphase separation method and the influence of factors like surfactant type and its amount, lipid concentration, cholesterol amount and drug content were studied. Span 60 was the most appropriate surfactant, and yielded vesicle size and percentage encapsulation efficiency of 1.3 mm and 98.9%, respectively. The developed system was characterised w.r.t. morphology, transition temperature, drug release, skin permeation and skin irritancy. Proniosomes exhibited a sustained release pattern of BCT in vitro. Skin permeation study revealed high penetration of proniosomes with sustained release of BCT through rat skin. The optimised proniosomal formulation showed enhanced transdermal flux of 16.15 mg/cm 2 /h as compared to 3.67 mg/cm 2 /h for drug dispersion. The developed formulations were observed as non-irritant to the rat skin and were found as quite stable at 4 and 25 C for 90 days w.r.t. vesicle size and drug content. The dried proniosomal formulation could act as a promising alternative to niosomes and preferably for transdermal delivery of BCT.

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“…In vivo efficacy in rats showed that ursolic acid-loaded niosomes had a significant improvement vis-a-vis oral ursolic acid formulation and the conventional gel system. Luteolin-loaded niosomes were prepared using different nonionic surfactants and were characterized for in vitro and in vivo anti-arthritic activity, providing both the improved entrapment efficiency and enhanced transdermal flux across the rat skin [ 66 ]. The in vivo bioactivity studies revealed that the prepared luteolin-loaded niosomes were able to provide good anti-arthritic activity compared to the standard gel.…”

Section: Anti-ra Activity Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis

et al. 2018

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Rheumatoid arthritis (RA), a chronic and joint-related autoimmune disease, results in immune dysfunction and destruction of joints and cartilages. Small molecules and biological therapies have been applied in a wide variety of inflammatory disorders, but their utility as a therapeutic agent is limited by poor absorption, rapid metabolism, and serious side effects. To improve these limitations, nanoparticles, which are capable of encapsulating and protecting drugs from degradation before they reach the target site in vivo, may serve as drug delivery systems. The present research proposes a platform for different lipid nanoparticle approaches for RA therapy, taking advantage of the newly emerging field of lipid nanoparticles to develop a targeted theranostic system for application in the treatment of RA. This review aims to present the recent major application of lipid nanoparticles that provide a biocompatible and biodegradable delivery system to effectively improve RA targeting over free drugs via the presentation of tissue-specific targeting of ligand-controlled drug release by modulating nanoparticle composition.

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Enhanced transdermal delivery of luteolin via non-ionic surfactant-based vesicle: quality evaluation and anti-arthritic assessment

Cited by 53 publications

References 27 publications

Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15

Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis

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