Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis

Abstract

Rheumatoid arthritis (RA), a chronic and joint-related autoimmune disease, results in immune dysfunction and destruction of joints and cartilages. Small molecules and biological therapies have been applied in a wide variety of inflammatory disorders, but their utility as a therapeutic agent is limited by poor absorption, rapid metabolism, and serious side effects. To improve these limitations, nanoparticles, which are capable of encapsulating and protecting drugs from degradation before they reach the target site in vivo, may serve as drug delivery systems. The present research proposes a platform for different lipid nanoparticle approaches for RA therapy, taking advantage of the newly emerging field of lipid nanoparticles to develop a targeted theranostic system for application in the treatment of RA. This review aims to present the recent major application of lipid nanoparticles that provide a biocompatible and biodegradable delivery system to effectively improve RA targeting over free drugs via the presentation of tissue-specific targeting of ligand-controlled drug release by modulating nanoparticle composition.

A Dual Bioconjugated Virus-Like Nanoparticle as a Drug Delivery System and Comparison with a pH-Responsive Delivery System

“…Loading drugs into VLNPs improves the solubility of insoluble drugs [ 41 , 42 , 44 ] and protects labile drugs from degradation in biological environments [ 44 , 45 ]. However, a drug must possess a certain charge and size in order to be packaged in a VLNP.…”

Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?

“…In particular, PEMFs has been demonstrated to exert an anti-inflammatory effect resulted in early pain control and enhanced functional recovery in the knee diseases, reducing knee osteoarthritic lesion progression with long term positive benefits for patients [ 24 , 25 ]. At the same time, it is well known that a single-dose intra-articular administration of liposomes within a synovial joint, can be used to treat the inflammatory process [ 26 , 27 ]. Therefore, a novel concept of enhanced localized treatments could be proposed combining the functionalities of the magneto-mechanical actuation and the healing properties of a non–thermal magnetic field.…”

Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis

“…The preparation strategies of NLCs, considering selection of solid and liquid lipids, type of surfactants and their formulation, play an instrumental role in biomedical applications in cancer therapy (85) and autoimmune systemic inflammatory diseases, such as psoriasis and RA (86). At present, research on NLCs is limited to preclinical studies with clinical applications remaining far from realization.…”