Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel

Singka, Gillian S Leslie; Samah, Nor Hayati Abu; Zulfakar, Mohd Hanif; Yurdasiper, Aysu; Heard, Charles Martin

doi:10.1016/j.ejpb.2010.06.014

Cited by 75 publications

(49 citation statements)

References 28 publications

(30 reference statements)

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“…Topical delivery of nanogel of MTX consisting of copolymerized Nisopropylacrylamide (NIPAM) and butylacrylate (BA) polymer in the presence of Na 2 CO 3 was studied by Singka et al Porcine epidermal membranes mounted in Franz diffusion cells ex vivo were used. MTX-loaded nanogel when applied showed 33 and 57% reduction in PGE 2 level in absence and presence of Na 2 CO 3, respectively [59].…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Methotrexate: a detailed review on drug delivery and clinical aspects

Khan

Tripathi

Mishra³

2012

Expert Opinion on Drug Delivery

204

133

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Therapeutic drug monitoring of MTX is crucial to attain a good efficacy. In spite of the advantages of multiparticulate, prodrug and drug conjugates, clinical applications of such formulations of MTX are still under infancy. These drug delivery systems require the special attention of medical experts for its wider clinical usage, and pharmaceutical experts for its scale-up. The combination of MTX with other antineoplastic and immunosuppressants should also be subjected to clinical trials, such as the combination of misoprostol with MTX in abortion.

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Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Methotrexate: a detailed review on drug delivery and clinical aspects

Khan

Tripathi

Mishra³

2012

Expert Opinion on Drug Delivery

204

133

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“…Although NIPA derivatives are widely recognized as potential drug carriers and nanocarriers, their practical application has been limited by their poor biodegradability. NIPA derivatives have been used effectively in the field of topical medicine, as exemplified by their use in several other studies [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, evaluation and release studies of NIPA nanopolymers presumed for temperature-controlled drug delivery

Gasztych

Valh

Kokol

et al. 2016

J Sol-Gel Sci Technol

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The copolymers of N-isopropyl acrylamide (NIPA) have been studied extensively as drug carriers for antibacterial, cardiovascular, cytostatic, local anesthetic, and nonsteroidal anti-inflammatory agents, to deliver the required therapeutic effect. The aim of this work was to evaluate the effect of a series of newly synthesized thermosensitive polymeric NIPA derivatives on the release rate of naproxen sodium (NS) from hydrogels composed of hydroxypropyl methylcellulose (HPMC). NIPA derivatives P1-P4 were synthesized by precipitation polymerization without an emulsifier, and their structures were evaluated by NMR spectroscopy. Four formulations were prepared with NS (FP1-FP4), and rate of NS release from these systems was evaluated using a modified pharmacopeial method at 22 and 42°C. The release rate of NS followed a similar trend in all four of the formulations assessed at 22°C, which was the same as the reference formulation. However, the release rate of NS at 42°C was clearly faster in the samples containing the thermosensitive polymers P1-P4 compared with the reference formulation. These results clearly demonstrate that the use of thermosensitive polymeric derivatives of NIPA can increase the release rate of NS from hydrophilic gels based on HPMC.Graphical Abstract Diversity of release courses of naproxen sodium evaluated in formulation containing poly(ethylene glycol) dimethacrylate (PDA, left), and comparison of half-release times (T HR , right) of naproxen sodium formulations containing various thermosensitive polymers P1-P4.

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“…These materials are of great interest owing to their diverse applications in the fields of medicine and pharmacy, where they serve as drug delivery systems [1]. They are also used as membranes in separation and desalination, they serve as chromatographic stationary phase and super adsorbents [2][3][4][5], and they are used in sensing applications [6].…”

Section: Introductionmentioning

confidence: 99%