Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors

McDaid, William J.; Lissin, Nikolai; Pollheimer, Ellen; Greene, Michelle K.; Leach, Adam; Smyth, Peter; Bossi, Giovanna; Longley, Daniel B.; Cole, David K.; Scott, Christopher J.

doi:10.1039/d1nr04001d

Cited by 6 publications

(2 citation statements)

References 42 publications

(50 reference statements)

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“…By conjugating drugs or drug-loaded nanoparticles to these antibodies, the DDS can deliver the therapeutic agents to the desired cells, while avoiding healthy cells. This method is commonly known as antibody-drug conjugate (ADC) therapy [159].…”

Section: Preparation and Characterization Of Anti-obesity Ddssmentioning

confidence: 99%

Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges

Ashour,

Mabrouk,

Aboelnasr

et al. 2023

Pharmaceutics

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Obesity has reached an epidemic proportion in the last thirty years, and it is recognized as a major health issue in modern society now with the possibility of serious social and economic consequences. By the year 2030, nearly 60% of the global population may be obese or overweight, which emphasizes a need for novel obesity treatments. Various traditional approaches, such as pharmacotherapy and bariatric surgery, have been utilized in clinical settings to treat obesity. However, these methods frequently show the possibility of side effects while remaining ineffective. There is, therefore, an urgent need for alternative obesity treatments with improved efficacy and specificity. Polymeric materials and chemical strategies are employed in emerging drug delivery systems (DDSs) to enhance therapy effectiveness and specificity by stabilizing and controlling the release of active molecules such as natural ingredients. Designing DDSs is currently a top priority research objective with an eye towards creating obesity treatment approaches. In reality, the most recent trends in the literature demonstrate that there are not enough in-depth reviews that emphasize the current knowledge based on the creation and design of DDSs for obesity treatment. It is also observed in the existing literature that a complex interplay of different physical and chemical parameters must be considered carefully to determine the effectiveness of the DDSs, including microneedles, for obesity treatment. Additionally, it is observed that these properties depend on how the DDS is synthesized. Although many studies are at the animal-study stage, the use of more advanced DDS techniques would significantly enhance the development of safe and efficient treatment approaches for obese people in the future. Considering these, this review provides an overview of the current anti-obesity treatment approaches as well as the conventional anti-obesity therapeutics. The article aims to conduct an in-depth discussion on the current trends in obesity treatment approaches. Filling in this knowledge gap will lead to a greater understanding of the safest ways to manage obesity.

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Section: Preparation and Characterization Of Anti-obesity Ddssmentioning

confidence: 99%

Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges

Ashour,

Mabrouk,

Aboelnasr

et al. 2023

Pharmaceutics

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“…[277] Recently, McDaid et al reported docetaxel-loaded polymeric nanoparticles to recombinant affinityenhanced TCRs for targeting breast cancer cells expressing the HLA complex, and showed that they improved the efficiency of immunotherapy. [278] In 2015, Ploegh and co-workers used two unused 18 F-coupled anti-MHC-II Nb clones for PET imaging to monitor the infiltration of MHC-II + cells into various mouse tumors. The two MHC-II Nbs facilitated the monitoring of the immune response during treatment, indicated the outcome, and provided visual information for deciding whether treatment should be stopped or continued.…”

Section: Mhcmentioning

confidence: 99%

Emerging Biomaterials Imaging Antitumor Immune Response

Zhang

Wang

et al. 2022

Advanced Materials

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Immunotherapy is one of the most promising clinical modalities for the treatment of malignant tumors and has shown excellent therapeutic outcomes in clinical settings. However, it continues to face several challenges, including long treatment cycles, high costs, immune‐related adverse events, and low response rates. Thus, it is critical to predict the response rate to immunotherapy by using imaging technology in the preoperative and intraoperative. Here, the latest advances in nanosystem‐based biomaterials used for predicting responses to immunotherapy via the imaging of immune cells and signaling molecules in the immune microenvironment are comprehensively summarized. Several imaging methods, such as fluorescence imaging, magnetic resonance imaging, positron emission tomography imaging, ultrasound imaging, and photoacoustic imaging, used in immune predictive imaging, are discussed to show the potential of nanosystems for distinguishing immunotherapy responders from nonresponders. Nanosystem‐based biomaterials aided by various imaging technologies are expected to enable the effective prediction and diagnosis in cases of tumors, inflammation, and other public diseases.

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