Enhanced Spinal Cord Regeneration in Lamprey by Applied Electric Fields

Borgens, Richard B.; Roederer, E; Cohen, Melvin J.

doi:10.1126/science.7256258

Cited by 186 publications

(100 citation statements)

References 25 publications

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“…It is well documented that endogenous electric fields play a role in regeneration, and it has been shown that applied electric fields are able to enhance regeneration and repair in vertebrates (Borgens et al, 1977(Borgens et al, , 1981Kerns and Lucchinetti, 1992;McCaig et al, 2005). have recently demonstrated a molecular link between electric currents and tail regeneration in Xenopus.…”

Section: Electric Currents and Regenerationmentioning

confidence: 99%

Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms

Beck

Belmonte

Christen

2009

Developmental Dynamics

147

139

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While Xenopus is a well-known model system for early vertebrate development, in recent years, it has also emerged as a leading model for regeneration research. As an anuran amphibian, Xenopus laevis can regenerate the larval tail and limb by means of the formation of a proliferating blastema, the lens of the eye by transdifferentiation of nearby tissues, and also exhibits a partial regeneration of the postmetamorphic froglet forelimb. With the availability of inducible transgenic techniques for Xenopus, recent experiments are beginning to address the functional role of genes in the process of regeneration. The use of soluble inhibitors has also been very successful in this model. Using the more traditional advantages of Xenopus, others are providing important lineage data on the origin of the cells that make up the tissues of the regenerate. Finally, transcriptome analyses of regenerating tissues seek to identify the genes and cellular processes that enable successful regeneration.

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Section: Electric Currents and Regenerationmentioning

confidence: 99%

Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms

Beck

Belmonte

Christen

2009

Developmental Dynamics

147

139

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“…Our initial studies investigated the therapeutic potential of ES in nerve regeneration following a rat facial nerve crush injury because of ES's enhancing effects on the morphological and functional properties of neurons [1][2][3][4]. In these studies, daily, low-frequency ES hastened the onset of recovery of the eye blink reflex by reducing the initial delay in sprout formation rather than by increasing the rate of axonal regeneration, indicating that ES acts primarily on events in the early stages of recovery [5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…Applying electrical stimulation (ES) has been shown to affect morphological and functional properties of neurons such as nerve branching, rate and orientation of neurite growth, rapid sprouting, and guidance during axon regeneration [1][2][3][4]. Therefore, ES has been explored as a therapeutic strategy for improving the outcome of peripheral nerve injury.…”

Section: Introductionmentioning

confidence: 99%

Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve

Foecking

Fargo²,

Coughlin³

et al. 2012

JRRD

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Abstract-Peripheral nerve injuries lead to a variety of pathological conditions, including paresis or paralysis when the injury involves motor axons. We have been studying ways to enhance the regeneration of peripheral nerves using daily electrical stimulation (ES) following a facial nerve crush injury. In our previous studies, ES was not initiated until 24 h after injury. The current experiment tested whether ES administered immediately following the crush injury would further decrease the time for complete recovery from facial paralysis. Rats received a unilateral facial nerve crush injury and an electrode was positioned on the nerve proximal to the crush site. Animals received daily 30 min sessions of ES for 1 d (day of injury only), 2 d, 4 d, 7 d, or daily until complete functional recovery. Untreated animals received no ES. Animals were observed daily for the return of facial function. Our findings demonstrated that one session of ES was as effective as daily stimulation at enhancing the recovery of most functional parameters. Therefore, the use of a single 30 min session of ES as a possible treatment strategy should be studied in human patients with paralysis as a result of acute nerve injuries.

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“…The spontaneous repetitive discharges are further conducted into the center to elicit spontaneous pains. Borgens et al [112][113][114][115] reported that the spinal cord responded to the damages of hemisection, transection, and other complete injuries, by generating large and persistent electrical signals.…”

Section: Neurogenic Painmentioning

confidence: 99%

Spontaneous high-frequency action potential

Shen

Choe

2011

Sci. China Life Sci.

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Action potential, which is the foundation of physiology and electrophysiology, is most vital in physiological research. This work starts by detecting cardiac electrophysiology (tachyarrhythmias), combined with all spontaneous discharge phenomena in vivo such as wound currents and spontaneous neuropathic pain, elaborates from generation, induction, initiation, to all of the features of spontaneous high-frequency action potential--SSL action potential mechanism, i.e., connecting-end hyperpolarization initiates spontaneous depolarization and action potential in somatic membrane. This work resolves the conundrums of in vivo spontaneous discharge in tachyarrhythmias, wounds, denervation supersensitivity, neurogenic pain (hyperalgesia and allodynia), epileptic discharge and diabetic pain in pathophysiological and clinical researches that have puzzled people for a hundred years. action potential, spontaneous high-frequency action potential, tachyarrhythmias, atrial fibrillation, wound, denervation supersensitivity, neurogenic pain, hyperalgesia and allodynia, epileptic discharge, diabetic pain, regeneration and development Citation:Shen H Y, Choe W C. Spontaneous high-frequency action potential. Sci China Life Sci, 2011Sci, , 54: 311 -335, doi: 10.1007 Wound, nerve disconnection, and atrial fibrillation (AF) induced by the excessive atrial dilation, are commonly characterized by the spontaneous repetitive discharge. Their common induction is the disconnection of intercellular connection, and their common result is the initiation of spontaneous high-frequency discharge, which discloses the existence of the special action of intercellular connection.The Hodgkin-Huxley model has predicted, and the computer models in applied mathematics have well demonstrated, that potassium leakage causes persistent spontaneous electrifying state with spontaneous oscillation of high-frequency action potential. The sustained disconnection of connecting-end space induces potassium leakage in the connecting-end and consequently the sustained reduction of [K + ] i , which induces in vivo spontaneous high-frequency action potential in plasmalemma.To form an intercellular conduction, connecting-end space exerts action on ion diffusions, the alteration of the space alters ion diffusions (i.e., ionic permeability) in the connecting-end. The abolishment of connecting-end space action causes K + leakage and consequently the reduction of intracellular positive electropotential (IPE) (i.e., the increase of intracellular negative potential), which elevates resting somatic membrane potential and initiates action potential in somatic membrane. SSL action potential is named to the course from the initiation (i.e., connecting-end hyperpolarization) to the termination of somatic membrane action potential.Tachyarrhythmias that are characterized by spontaneous discharge have been most deeply studied. Their inductions contain both mechanical actions and chemical actions, and their courses contain the transformation from traditional action potential to SSL-ty...

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Enhanced Spinal Cord Regeneration in Lamprey by Applied Electric Fields

Cited by 186 publications

References 25 publications

Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms

Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms

Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve

Spontaneous high-frequency action potential

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