Enhanced solubilization of α-tocopherol by hyperbranched polyglycerol-modified β-cyclodextin

Kimura, Motomi; Ooya, Tooru

doi:10.1016/j.jddst.2016.06.005

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…The initial loading of Vitamin E in the fiber matrix is ∼26% (w/w) and ∼13% (w/w, respect to total fiber matrix) for Vitamin E/HPβCD-IC (1:1) NF and Vitamin E/HPβCD-IC (1:2) NF, respectively, whereas in our previous studies, generally we were able to load ∼5% (w/w) active agents − when fully complexed guest molecules with CD-IC was incorporated into polymeric electrospun matrix. More importantly, unlike the usual CD-IC, which are mostly in solutions or powder forms , here, we successfully produced nanofibrous webs from Vitamin E/HPβCD-IC by using electrospinning technique as a free-standing material (Figure ).…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Çelebioğlu

Uyar

2017

J. Agric. Food Chem.

101

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Here, we demonstrated the electrospinning of polymer-free nanofibrous webs from inclusion complex (IC) between hydroxypropyl-β-cyclodextrin (HPβCD) and Vitamin E (Vitamin E/HPβCD-IC NF). The inclusion complexation between HPβCD and Vitamin E was prepared by using two different molar ratios (Vitamin E/HPβCD; 1:2 and 1:1), which correspond to theoretical value of ∼13% (w/w) and 26% (w/w) loading of Vitamin E in the nanofiber (NF) matrix. After electrospinning and storage, a very high loading of Vitamin E (up to ∼11% w/w, with respect to fiber matrix) was preserved in Vitamin E/HPβCD-IC NF. Because of the cyclodextrin inclusion complexation, only a minimal weight loss (only ∼2% w/w) was observed. While pure Vitamin E is insoluble in water, Vitamin E/HPβCD-IC NF web has displayed fast-dissolving behavior. Because of the greatly enhanced water-solubility of Vitamin E, Vitamin E/HPβCD-IC NF web has shown effective antioxidant activity. Additionally, Vitamin E/HPβCD-IC NF web has provided enhanced photostability for the sensitive Vitamin E by the inclusion complexation in which Vitamin E/HPβCD-IC NF still kept its antioxidant activity even after exposure to UV-light. Moreover, a 3 year-old Vitamin E/HPβCD-IC NF sample has shown very similar antioxidant efficiency when compared with freshly prepared Vitamin E/HPβCD-IC NF indicating that long-term stability was achieved for Vitamin E in the CD-IC fiber matrix. In brief, our results suggested that polymer-free electrospun Vitamin E/HPβCD-IC nanofibrous webs could have potential applications in food, pharmaceuticals, and healthcare thanks to its efficient antioxidant activity along with enhanced water-solubility, prolonged shelf life, and high photostability of Vitamin E.

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Section: Resultsmentioning

confidence: 99%

“…Article was incorporated into polymeric electrospun matrix. More importantly, unlike the usual CD-IC, which are mostly in solutions 35 or powder forms 31,36 here, we successfully produced nanofibrous webs from Vitamin E/HPβCD-IC by using electrospinning technique as a free-standing material ( Figure 1).…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Çelebioğlu

Uyar

2017

J. Agric. Food Chem.

101

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“…The solid phase was separated by centrifugation (3000 rpm) for 15 min. All of the samples were filtered using a 0.45 μm pore size filter before the HPLC measurement 25 using a Gilson HPLC system (Gilson 119 UV−vis detector, Gilson 231XL autosampler, Gilson 805 manometric module pump, Gilson 811c dynamic mixer, Gilson 306 pump, and a Gilson DILTOR401 injector) with a COSMOSIL 5C 18 -MS-II (Φ = 4.6 nm × 150 mm) column (Nacalai Tesque Inc., Japan) as the stationary phase at room temperature. Detection was performed at a wavelength of 227 nm.…”

Section: Methodsmentioning

confidence: 99%

“…The solid phase was separated by centrifugation (3000 rpm) for 15 min. All the samples were filtered using 0.45 µm pore size filter before HPLC measurement 25 solution was found to be higher than that of the other polymers, the solubility was further measured by increasing the copolymer concentration to 100 mg/ml.…”

Section: Determination Of Ptx Solubility In Various Poss-mpc Copolymementioning

confidence: 99%

Hydrophobic Nature of Methacrylate-POSS in Combination with 2-(Methacryloyloxy)ethyl Phosphorylcholine for Enhanced Solubility and Controlled Release of Paclitaxel

Chatterjee

Ooya

2018

Langmuir

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Amphiphilic copolymers consisting of 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) and hydrophobic monomers are known as biomaterials for the administration of poorly water-soluble drugs such as paclitaxel (PTX). However, the hydrophobic monomers to be copolymerized with MPC have not been optimized for PTX solubilization and its dosage forms. Here, we show the enhanced PTX solubility by only an MPC-based amphiphilic copolymer using a polyhedral oligomeric silsesquioxane (POSS) methacrylate (MA) bearing ethyl (C2H5) group as a vertex group. MPC was copolymerized with POSS methacrylates bearing different vertex groups of ethyl (C 2 H 5), hexyl (C 6 H 13) and octyl (C 8 H 17) via radical polymerization. We found that the strong interaction between the C2H5-POSS and PTX contributed to the slow release of PTX without any burst release. The C2H5-POSS-MA MPC copolymer was internalized into the cultured HeLa cells, which was confirmed by using a fluorescein-4-isothiocyanate (FITC)-labelled PTX, and the PTXdissolved copolymer induced cell death. We anticipate that C2H5-POSS-MA MPC copolymer is a good solubilizer bearing controlled release function for PTX.

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“…Hyperbranched polyglycerol is easy to synthesize and can generate high-molecular-weight polymers in a single step, which is difficult with the stepwise organic synthesis that is required for PGD. To date, PGDs and HPGs have been used as nanocapsules for drug delivery [ 5 , 6 ], dispersions of metal ions using host–guest interactions [ 7 ], protein adsorption inhibitory surfaces [ 8 , 9 , 10 , 11 , 12 ], hydrogels [ 13 , 14 , 15 , 16 , 17 ], human serum albumin substitutes [ 18 ], organ preservation solutions [ 19 ], and solvents for poorly water soluble drugs as hydrotropes [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel

Ooya

Lee

2022

Gels

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Polyglycerol dendrimers (PGD) exhibit unique properties such as drug delivery, drug solubilization, bioimaging, and diagnostics. In this study, PGD hydrogels were prepared and evaluated as devices for controlled drug release with good solubilization properties. The PGD hydrogels were prepared by crosslinking using ethylene glycol diglycidylether (EGDGE). The concentrations of EGDGE and PGDs were varied. The hydrogels were swellable in ethanol for loading paclitaxel (PTX). The amount of PTX in the hydrogels increased with the swelling ratio, which is proportional to EGDGE/OH ratio, meaning that heterogeneous crosslinking of PGD made high dense region of PGD molecules in the matrix. The hydrogels remained transparent after loading PTX and standing in water for one day, indicating that PTX was dispersed in the hydrogels without any crystallization in water. The results of FTIR imaging of the PTX-loaded PGD hydrogels revealed good dispersion of PTX in the hydrogel matrix. Sixty percent of the loaded PTX was released in a sink condition within 90 min, suggesting that the solubilized PTX would be useful for controlled release without any precipitation. Polyglycerol dendrimer hydrogels are expected to be applicable for rapid release of poorly water-soluble drugs, e.g., for oral administration.

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Enhanced solubilization of α-tocopherol by hyperbranched polyglycerol-modified β-cyclodextin

Cited by 11 publications

References 14 publications

Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Hydrophobic Nature of Methacrylate-POSS in Combination with 2-(Methacryloyloxy)ethyl Phosphorylcholine for Enhanced Solubility and Controlled Release of Paclitaxel

Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel

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