Enhanced signal intensity in matrix‐free laser desorption ionization mass spectrometry by chemical modification of bionanostructures from diatom cell walls

Abstract

Chemically modified diatom cell walls represent a powerful tool to support ionization in LDI MS. The lack of background signals in the low molecular weight region of the mass spectra allows also the investigations of small analytes.

1,8-Di(piperidinyl)-naphthalene – rationally designed MAILD/MALDI matrix for metabolomics and imaging mass spectrometry

“…One simply avoids such classic matrices, relying instead on various synthetic materials (e.g. modied silica and modied graphite) 4,5 or even polymeric biomaterials 6 to exploit the surface effects of the matrices; these surface effects are benecial to the laser desorption and ionization. Even so, the fact that most of these materials are insoluble in the usual solvents makes their application to the sample target a cumbersome step in the process of sample preparation.…”