Enhanced Serum Prolactin Concentration after Metoclopramide Stimulation in Idiopathic Oligozoospermia and Azoospermia

Baranowska, B; Jeske, Wojciech; Niewiadomska, A; Rozbicka, G; Walczak, Leszek; Zgliczyński, S

doi:10.1111/j.1439-0272.1983.tb00211.x

Cited by 5 publications

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“…In men the MCP-induced hyperprolactinemia is linked with a lowered testosterone (T) level in the blood serum, disorders in spermatogenesis and with oligospermia (Baranowska et al -1983;Rocco et al -1983). These disorders, which may evidence the MCP effect being exerted on the gametogenic and endocrinological function of testes, have given rise to a question whether the changes due to dopaminergic system blocking by MCP are restricted only to gonads, or their range is much wider and involve spermatozoa in the epididymis too.…”

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confidence: 99%

Zinc Content in Epididymal Spermatozoa of Metoclopramide-Treated Rats

et al. 2009

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Zinc content was determined separately in spermatozoa taken from epididymal caput and cauda in rats. It was revealed that spermatozoa transported from the epididymal caput to the cauda reduce about 54% of zinc. This reduction is significantly inhibited in spermatozoa of rats receiving metoclopramide. That is also accompanied by a fall of testosterone level in blood serum and of A5, 3P-HSD activity in Leydig cells. It was found out that the reduction of zinc in spermatozoa at the time of their passage through the epididymis is the process that depends on androgens. Der Zinkgehalt in den Spermatozoen aus dem Nebenhoden der mit Metoclopramid behandelten XattenZusammenfassung: Es wurde der Zinkgehalt bestimmtgetrennt in den vom Kopf und vom Nebenhodenschwanz entnommenen Spermatozoen. Es wurde gezeigt, dai3 die vom Kopf in den Nebenhodenschwanz transportierten Spermatozoen ca. 54% Zink reduzieren. Diese Reduktion ist in Spermatozoen der Ratten, denen Metoclopramid verabreicht wurde, stark gehemmt. Als Begleiterscheinung wurde ein Testosteronsturz in Blutserum und eine Aktivitatsminderung A5, 3P-HSD in Leydigzellen beobachtet. Es wurde festgestellt, dai3 die Zinkreduktion in den Spermatozoen wahrend des Durchgangs durch den Nebenhoden von den Androgenen abhangt.

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Section: Introductionmentioning

confidence: 99%

Zinc Content in Epididymal Spermatozoa of Metoclopramide-Treated Rats

et al. 2009

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“…The elevated PRL level is accompanied by disturbances in the secretory processes of epithelial cells in the epididymal caput (Laszczynska et al, 1989), changes in the spermatozoa at the time of their maturation in the epididymis (Kaminska et al, 1987), and some other disorders (Kaminska, 1988). As a central antagonist of dopamine MCP is an inhibitor of the hypothalamic factor hampering PRL secretion and, by acting in this way, it appears to be the compound that initiates hyperprolactinaemia and disturbs the hormonal system on the axis of hypothalamus-hypophysis-testis (Baranowska et al, 1983;Hassan et al, 1986). The MCP-induced hyperprolactinaemia provides a good model for studying this hormonal disorder.…”

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Evaluation of spermatozoa of the rat in hyperprolactinaemia induced by Metoclopramide

et al. 2009

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Metoclopramide (MCP) in doses of 2.2 mg kg-body weight, being administered intraperitoneally to rats for 14 d, provokes a premature release of germ cells in the testes. The number of spermatozoa is reduced. I n addition the spermatozoa exhibit defects of head and tail structures. After the administration of M C P for 14 d, followed by a 14-d break in applying the drug, the number of spermatozoa in the lumen of the epididymal duct continues to be low. Many spermatozoa are damaged. Only after a 66-dbreak in MCP administration is the morphology of the seminiferous epithelium restored, and a large number of spermatozoa appear in the lumen of the epididymal duct. IntroductionIn men hyperprolactinaemia disturbs the function of the reproductive system. Besides such symptoms as lowering or complete eradication of potency and libido, oligo-, astheno-, and teratozoospermia, and even azoospermia are encountered (Segal et al., 1976; Rocco et al., 1983). According to Cameron et al. ( 1984) and Katovich et al. (1985) the causes of the poor state of the semen, are changes in the testis, consisting in the degeneration of the adluminal parts of Sertoli cells, as well as disappearance of the junction between Sertoli cells and spermatids. This is due to germ cell exfoliation. The inappropriate release of germ cells causes a reduction in the number of spermatozoa.Our studies on the model

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Anabolic Steroids

Pasquale

1998

Handbook of Substance Abuse

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Enhanced Serum Prolactin Concentration after Metoclopramide Stimulation in Idiopathic Oligozoospermia and Azoospermia

Cited by 5 publications

References 12 publications

Zinc Content in Epididymal Spermatozoa of Metoclopramide-Treated Rats

Zinc Content in Epididymal Spermatozoa of Metoclopramide-Treated Rats

Evaluation of spermatozoa of the rat in hyperprolactinaemia induced by Metoclopramide

Anabolic Steroids

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