Enhanced Secondary Metabolite Production in Hairy Root Cultures Through Biotic and Abiotic Elicitors

Abstract

Natural products from plants are of major pharmaceutical and therapeutic importance, several of which are often obtained from the underground parts of the concerned plants, necessitating the uprooting and killing of the whole plants. The biosynthetic capacity of "hairy roots" has appeared to closely mirror that of the roots of the parent plant from which they are derived and therefore has extensively been studied as an effective alternate system for in vitro secondary metabolite production. The growth rates and secondary metabolite yields of such transformed roots have also been improved by adopting several measures, such as: by alterations in nutrient composition, carbohydrate source and their levels,

Xanthones Production in Gentiana dinarica Beck Hairy Root Cultures Grown in Simple Bioreactors

“…Further enhancement of biomass and of secondary metabolite production in bioreactors can be achieved by the application of biotic and abiotic elicitors [37]. Hairy root cultures were suitable for the treatments with various types of stress inducing elicitors, such as filter-sterilized fungal culture filtrates [35].…”