Enhanced renal cryoablation with hilar clamping and intrarenal cooling in a porcine model

Experimental cryosurgery investigations in vivo

“…Wooley et al in experiments in dogs, noted the greater destruction produced by repeater freezing cycles [214]. Collyer et al working with pigs, demonstrated that enhanced size of the frozen volume and necrosis was achieved with intra-renal cooling with saline-ice slush infused into the renal pelvis during laparoscopic cryoablation [36]. To resolve concerns about the effect of freezing on the renal pelvis, Janzen et al in experiments with swine, showed that the collecting system was preserved[97].…”

Anatomical study of the renal excretory system in pigs. A review of its characteristics as compared to its human counterpart

“…The importance of characterising the excretory system in pigs resides in the use of this species for teaching-learning processes in compared anatomy, and as an experimental model for surgical procedures of the kidney and renal physiology [4,5,8,10,13,14,16,19,23,33]. This work intends to generate meaningful information on these renal structures through the evaluation of a sample of commercial pigs within the context of comparative anatomy between human and porcine kidneys.…”

Impact of Pneumoperitoneum on Renal Cryotherapy

“…They concluded that arterial occlusion provided no practical advantage over direct treatment. Conversely, Collyer et al 16 found a significantly increased gross cryolesion diameter with occlusion of both the renal artery and vein in laparoscopic cryoablation in a porcine model. Although not statistically significant, the mean diameter of complete central necrosis was also 4 mm larger with hilar occlusion than without.…”