Enhanced photosensitizing properties of protein bound curcumin

Cozzolino, Marco; Delcanale, Pietro; Montali, Chiara; Tognolini, Massimiliano; Giorgio, Carmine; Corrado, Miriam; Cavanna, Luigi; Bianchini, Paolo; Diaspro, Alberto; Abbruzzetti, Stefania; Viappiani, Cristiano

doi:10.1016/j.lfs.2019.116710

Cited by 22 publications

(23 citation statements)

References 45 publications

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“…To this end, the use of transporters like proteins, liposomes or nanoparticles has been exploited to protect curcumin and other photosensitizers against the undesirable solvent effects. 33 This proved to be beneficial to PDT applications. This presents a very interesting future prospect of this study to enhance the properties of these four curcuminoids and elucidate further their mechanism of action.…”

Section: Discussionmentioning

confidence: 97%

“…13,[26][27][28] Some of the limitations reported for the potential clinical application of curcumin in PDT are its poor solubility, stability and photostability in aqueous solutions as well as the rapid metabolism and systemic elimination. [29][30][31][32][33] In most studies, commercially available curcumin is used. In this study pure samples of curcumin (1) synthesized in the lab are employed in the study of the PDT related properties.…”

Section: Discussionmentioning

confidence: 99%

“…Curcuminoids 1 and 2 possess a phenolic OH-group and in the case of 4 the nitrogen containing aromatic substitution may all form intramolecular H-bonds and π-stacking interactions leading to the formation of aggregates when dissolved in aqueous media. [31][32][33]40,41 The increased hydrophobicity, poor water solubility which easily leads to aggregated species under physiological conditions and drastically lowers the quantum yields of ROS production, has long been one of the main limitations for the clinical use of PDT. To this end, the use of transporters like proteins, liposomes or nanoparticles has been exploited to protect curcumin and other photosensitizers against the undesirable solvent effects.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Kazantzis

Koutsonikoli

Mavroidi

et al. 2020

Photochem Photobiol Sci

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Kazantzis

Koutsonikoli

Mavroidi

et al. 2020

Photochem Photobiol Sci

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“…CUR is a relatively hydrophobic polyphenolic compound that is readily soluble in organic solvents ( Figure 3 C). It absorbs visible light in the 405–435-nm range, depending on the solvent [ 151 ]. Despite CUR’s widespread use as a PS in API, the mechanisms of its phototoxicity are not completely understood.…”

Section: Antimicrobial Photoinactivationmentioning

confidence: 99%

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

Buchovec

Gricajeva

Kalėdienė

et al. 2020

IJMS

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A spacecraft is a confined system that is inhabited by a changing microbial consortium, mostly originating from life-supporting devices, equipment collected in pre-flight conditions, and crewmembers. Continuous monitoring of the spacecraft’s bioburden employing culture-based and molecular methods has shown the prevalence of various taxa, with human skin-associated microorganisms making a substantial contribution to the spacecraft microbiome. Microorganisms in spacecraft can prosper not only in planktonic growth mode but can also form more resilient biofilms that pose a higher risk to crewmembers’ health and the material integrity of the spacecraft’s equipment. Moreover, bacterial biofilms in space conditions are characterized by faster formation and acquisition of resistance to chemical and physical effects than under the same conditions on Earth, making most decontamination methods unsafe. There is currently no reported method available to combat biofilm formation in space effectively and safely. However, antibacterial photodynamic inactivation based on natural photosensitizers, which is reviewed in this work, seems to be a promising method.

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“…The uptake of curcumin by treated microbial cells can be determined using its fluorescence char-acteristics. Studies have shown that a few minutes of incubation resulted in fluorescence detection of curcumin from inside the cellular structures such as mitochondria (Cozzolino et al, 2019;Moustapha et al, 2015). Therefore, considerable cytotoxicity is generally expected from curcumin, which could be further enhanced by reactive oxygen species generation in close vicinity of cellular targets through photosensitization treatment.…”

Section: In Vitro Photoinactivation Of Food-related Microorganismsmentioning

confidence: 99%

An insight into curcumin‐based photosensitization as a promising and green food preservation technology

Damyeh

Mereddy

Netzel

2020

Comp Rev Food Sci Food Safe

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Consumer awareness on the side effects of chemical preservatives has increased the demand for natural preservation technologies. An efficient and sustainable alternative to current conventional preservation techniques should guarantee food safety and retain its quality with minimal side effects. Photosensitization, utilizing light and a natural photosensitizer, has been postulated as a viable and green alternative to the current conventional preservation techniques. The potential of curcumin as a natural photosensitizer is reviewed in this paper as a practical guide to develop a safe and effective decontamination tool for industrial use. The fundamentals of the photosensitization mechanism are discussed, with the main emphasis on the natural photosensitizer, curcumin, and its application to inactivate microorganisms as well as to enhance the shelf life of foods. Photosensitization has shown promising results in inactivating a wide spectrum of microorganisms with no reported microbial resistance due to its particular lethal mode of targeting nucleic acids. Curcumin as a natural photosensitizer has recently been investigated and demonstrated efficacy in decontamination and delaying spoilage. Moreover, studies have shown the beneficial impact of an appropriate encapsulation technique to enhance the cellular uptake of photosensitizers, and therefore, the phototoxicity. Further studies relating to improved delivery of natural photosensitizers with inherent poor solubility should be conducted. Also, detailed studies on various food products are warranted to better understand the impact of encapsulation on curcumin photophysical properties, photodriven release mechanism, and nutritional and organoleptic properties of treated foods.

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Enhanced photosensitizing properties of protein bound curcumin

Cited by 22 publications

References 45 publications

Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

An insight into curcumin‐based photosensitization as a promising and green food preservation technology

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