Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Kazantzis, K T; Koutsonikoli, K; Mavroidi, Barbara; Zachariadis, Michael; Alexiou, Panagiotis; Pelecanou, Maria; Politopoulos, Konstantinos; Alexandratou, Eleni; Sagnou, Marina

doi:10.1039/c9pp00375d

Cited by 103 publications

(68 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on this hypothesis, the antifungal effect of bisdemethoxycurcumin might be lower than that of demethoxycurcumin, but in our study, a dramatic reduction in Candida albicans cells was observed as caused by the bisdemethoxycurcumin-containing test photosensitizer, and thus we hypothesized that the effect of ROS itself plays a more major role than the fungal cell adhesion ability of photosensitizers in Candidiasis suppression. This was also found in the study of Kazantzis et al [ 29 ], showing evidence that the lack of the methoxy-aromatic substitution in bisdemethoxycurcumin favors a high degree of free radical production.…”

Section: Discussionsupporting

confidence: 77%

Inhibitory Effects of Erythrosine/Curcumin Derivatives/Nano-Titanium Dioxide-Mediated Photodynamic Therapy on Candida albicans

et al. 2021

View full text Add to dashboard Cite

This study focuses on the role of photosensitizers in photodynamic therapy. The photosensitizers were prepared in combinations of 110/220 µM erythrosine and/or 10/20 µM demethoxy/bisdemethoxy curcumin with/without 10% (w/w) nano-titanium dioxide. Irradiation was performed with a dental blue light in the 395–480 nm wavelength range, with a power density of 3200 mW/cm2 and yield of 72 J/cm2. The production of ROS and hydroxyl radical was investigated using an electron paramagnetic resonance spectrometer for each individual photosensitizer or in photosensitizer combinations. Subsequently, a PrestoBlue® toxicity test of the gingival fibroblast cells was performed at 6 and 24 h on the eight highest ROS-generating photosensitizers containing curcumin derivatives and erythrosine 220 µM. Finally, the antifungal ability of 22 test photosensitizers, Candida albicans (ATCC 10231), were cultured in biofilm form at 37 °C for 48 h, then the colonies were counted in colony-forming units (CFU/mL) via the drop plate technique, and then the log reduction was calculated. The results showed that at 48 h the test photosensitizers could simultaneously produce both ROS types. All test photosensitizers demonstrated no toxicity on the fibroblast cells. In total, 18 test photosensitizers were able to inhibit Candida albicans similarly to nystatin. Conclusively, 20 µM bisdemethoxy curcumin + 220 µM erythrosine + 10% (w/w) nano-titanium dioxide exerted the highest inhibitory effect on Candida albicans.

show abstract

Section: Discussionsupporting

confidence: 77%

Inhibitory Effects of Erythrosine/Curcumin Derivatives/Nano-Titanium Dioxide-Mediated Photodynamic Therapy on Candida albicans

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Synthetic derivatives of curcumin, cinnamaldehyde and dimethylamino derivative, were reported to improve sensitization of LNCaP cells for photodynamic therapy at concentration of 3 μM. Curcuminoid dimethylamino derivative reduced cell survivability in a dose-dependent manner ( Kazantzis et al, 2020 ). Performing curcumin derivatives and photodynamic therapy together on other PCa cell lines and in animal models might give a novel method for curbing this disease.…”

Section: Natural Compounds On the Basis Of Androgen Status Of The Canmentioning

confidence: 99%

MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer

et al. 2021

View full text Add to dashboard Cite

Prostate cancer (PCa) is with rising incidence in male population globally. It is a complex anomaly orchestrated by a plethora of cellular processes. Transforming growth factor-beta (TGF-β) signaling is one of the key signaling pathways involved in the tumorigenesis of PCa. TGF-β signaling has a dual role in the PCa, making it difficult to find a suitable therapeutic option. MicroRNAs (miRNAs) mediated regulation of TGF-β signaling is responsible for the TGF-ß paradox. These are small molecules that modulate the expression of target genes and regulate cancer progression. Thus, miRNAs interaction with different signaling cascades is of great attention for devising new diagnostic and therapeutic options for PCa. Natural compounds have been extensively studied due to their high efficacy and low cytotoxicity. Here, we discuss the involvement of TGF-ß signaling in PCa with the interplay between miRNAs and TGF-β signaling and also review the role of natural compounds for the development of new therapeutics for PCa.

show abstract

“…A highly conjugated chemical structure results in visible light spectrum absorption, as well as mediation of reactive oxygen species generation upon irradiation. These facts mean that CUR and its derivatives are also considered as potential photosensitizers in photodynamic therapy (PDT) against tumors and infectious diseases [25,26]. Another property that impacts the biological activity of curcuminoids is their tendency to form strong metal complexes.…”

Section: The Biological Activities Of Cur and Egcgmentioning

confidence: 99%

Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review

Piwowarczyk

Stawny

Mlynarczyk

et al. 2020

Cancers

View full text Add to dashboard Cite

The incidence of bladder cancer (BC) is increasing, and although current therapeutic approaches are effective in many cases, recurrence of BC is common. Therefore, it seems necessary to search not only for novel therapeutic approaches, but also for new therapeutic agents. Natural polyphenols, such as curcumin (CUR) and epigallocatechin gallate (EGCG), possess remarkable antitumor activity. Their biochemical mechanisms of action include regulation of signaling pathways, modeling of proteins involved in apoptosis and cell cycle inhibition, angiogenesis, and the proliferation, migration and adhesion of tumor cells. Both compounds also present antioxidant, anti-inflammatory, antibacterial and antiviral properties. CUR has been considered a promising candidate for the treatment of cystic fibrosis, Alzheimer’s disease or malaria, whereas EGCG can play a supportive role in the treatment of obesity, metabolic and neurodegenerative diseases. The review summarizes the latest research on the role of CUR and EGCG in the treatment of BC. In particular, the effects of CUR and EGCG, and their prospects for use in BC therapy, their inhibition of cancer development and their prevention of multidrug resistance, are described. The literature’s data indicate the possibility of achieving the effect of synergism of both polyphenols in BC therapy, which has been observed so far in the treatment of ovarian, breast and prostate cancer.

show abstract

Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Abstract:
Increased absorption maximum for the dimethylaminocurcumin with strong PD effect on prostate cancer cells; Intense PD effect of curcumin III on prostate cancer cells; Exciting biphasic PD response by curcumin I and cinnamaldehyde-derived curcumin.

Cited by 103 publications

References 54 publications

Inhibitory Effects of Erythrosine/Curcumin Derivatives/Nano-Titanium Dioxide-Mediated Photodynamic Therapy on Candida albicans

Inhibitory Effects of Erythrosine/Curcumin Derivatives/Nano-Titanium Dioxide-Mediated Photodynamic Therapy on Candida albicans

MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer

Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review

Contact Info

Product

Resources

About

Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

Abstract: Increased absorption maximum for the dimethylaminocurcumin with strong PD effect on prostate cancer cells; Intense PD effect of curcumin III on prostate cancer cells; Exciting biphasic PD response by curcumin I and cinnamaldehyde-derived curcumin.

Cited by 103 publications

References 54 publications

Inhibitory Effects of Erythrosine/Curcumin Derivatives/Nano-Titanium Dioxide-Mediated Photodynamic Therapy on Candida albicans

Inhibitory Effects of Erythrosine/Curcumin Derivatives/Nano-Titanium Dioxide-Mediated Photodynamic Therapy on Candida albicans

MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer

Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review

Contact Info

Product

Resources

About

Abstract:
Increased absorption maximum for the dimethylaminocurcumin with strong PD effect on prostate cancer cells; Intense PD effect of curcumin III on prostate cancer cells; Exciting biphasic PD response by curcumin I and cinnamaldehyde-derived curcumin.