Enhanced permeability across Caco-2 cell monolayers by specific mannosylating ligand of buserelin acetate proliposomes

Yingsukwattana, Koson; Puttipipatkhachorn, Satit; Ruktanonchai, Uracha; Sarisuta, Narong

doi:10.3109/08982104.2015.1039030

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…Oral digestibility of liposomes triggered the formulation of modified generations of vesicular systems with higher GIT stability. 26,27 Next generations of liposomes with stability include phytosomes 23 and, more recently, bilosomes. 28,29 Bilosomes are BS-integrated liposomes for improving oral delivery of actives.…”

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confidence: 99%

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Elnaggar¹

2015

IJN

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The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs’ metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs’ potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined.

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confidence: 99%

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Elnaggar¹

2015

IJN

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“…The cationic polymer EE shows its characteristics peaks at around 1720 cm −1 (for the ester group) and the slight peaks at around 2780 cm −1 and 2850 cm −1 as evidence of the dimethylamino groups [46,47]. While Lys shows its characteristics peaks at around 1630 cm −1 and 1520 cm −1 corresponding to its amine bands [48,49,50]. The combined system, exemplified by Lys-loaded pNPs CT 20 and RC 0.5, shows similar peaks to the pure materials with no evidence of new chemical entities.…”

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confidence: 99%

Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety

et al. 2019

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The number of biologic drugs has increased in the pharmaceutical industry due to their high therapeutic efficacy and selectivity. As such, safe and biocompatible delivery systems to improve their stability and efficacy are needed. Here, we developed novel cationic polymethacrylate-alginate (EE-alginate) pNPs for the biologic drug model lysozyme (Lys). The impact of variables such as total charge and charge ratios over nanoparticle physicochemical properties as well as their influence over in vitro safety (viability/proliferation and cell morphology) on HeLa cells was investigated. Our results showed that electrostatic interactions between the EE-alginate and lysozyme led to the formation of EE/alginate Lys pNPs with reproducible size, high stability due to their controllable zeta potential, a high association efficiency, and an in vitro sustained Lys release. Selected formulations remained stable for up to one month and Fourier transform-Infrared (FT-IR) showed that the functional groups of different polymers remain identifiable in combined systems, suggesting that Lys secondary structure is retained after pNP synthesis. EE-alginate Lys pNPs at low concentrations are biocompatible, while at high concentrations, they show cytotoxic for HeLa cells, and this effect was found to be dose-dependent. This study highlights the potential of the EE-alginate, a novel polyelectrolyte complex nanoparticle, as an effective and viable nanocarrier for future drug delivery applications.

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Effect of calcium chloride on the protein encapsulation and stability of proliposomal granules

Tunsirikongkon

Pyo

Kim

et al. 2020

Journal of Drug Delivery Science and Technology

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Enhanced permeability across Caco-2 cell monolayers by specific mannosylating ligand of buserelin acetate proliposomes

Abstract: The significantly enhanced permeability across Caco-2 cell monolayers of MANS-BA liposomes might be due to the role of mannose receptor on intestinal enterocytes.

Cited by 5 publications

References 39 publications

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety

Effect of calcium chloride on the protein encapsulation and stability of proliposomal granules

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