Enhanced performance of label-free electrochemical immunosensor for carbohydrate antigen 15-3 based on catalytic activity of cobalt sulfide/graphene nanocomposite

Khoshroo, Alireza; Mazloum-Ardakani, Mohammad; Forat-Yazdi, Mohammad

doi:10.1016/j.snb.2017.08.114

Cited by 71 publications

(29 citation statements)

References 36 publications

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“…The developed immunosensor showed a wide linear range of 0.1-150 U mL −1 and a low detection limit of 0.03 U mL −1 . The immunosensor demonstrated good precision, reliability, specificity and was successfully applied in serum samples for CA15-3 detection [12].…”

Section: Cancer Antigen 15-3 (Ca15-3)mentioning

confidence: 98%

Current and Prospective of Breast Cancer Biomarkers

Benjamin¹,

Lima²

2021

Molecular Biotechnology

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Biomarkers have shown great promise over the past decade the process of drug development more effective and have become an integral part of diagnosis of diseases. Biosensors were integrated with biomarker detection and point-of-care detection for signal amplification, high specificity and sensitivity, rapid response time, low cost, simplicity and multi-analytical testing. In order to detect more sensitively, these particular biomarkers have been explored with the possibility of real-time measurements in order to develop simple and compact systems which can analyze complex specimens. Various biosensors including electrochemical biosensors have recently been developed based on disease-specific biomarkers in the diagnosis of cancer disease. The main objective of the book chapter is to review research with new materials/methods in electrochemical biosensing techniques to detection of breast cancer biomarkers and evaluating latest techniques for detection of important analytes in real samples. In this book chapter, the recent development of electrochemical biosensors of breast cancer biomarkers will be reviewed. Furthermore, recent and future trend application of breast cancer biomarkers will be discussed.

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Section: Cancer Antigen 15-3 (Ca15-3)mentioning

confidence: 98%

Current and Prospective of Breast Cancer Biomarkers

Benjamin¹,

Lima²

2021

Molecular Biotechnology

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“…The electrochemical immunosensor was employed to detect CYFRA21-1 and exhibited a wide linear range of 0.25-800 ng/mL and low detection limit of 100 pg/mL. Other nanoparticles as cobalt sulfide [669] (detection of CA15-3 antigen in wide linear range of 0.1-150 U mL −1 and a low detection limit of 0.03 U mL −1 ), Pd [670] (prostate-specific antigen with sensitivity 28.96 µA mL ng −1 cm −2 corresponding to 10 pg mL −1 ), oxides as ZrO 2 [671] (CYFRA-21-1 biomarker with sensitivity 0.756 µA mL ng −1 and a remarkable lower detection limit of 0.122 ng mL −1 ), Fe 3 O 4 [672] (detection of prostate specific antigen or prostate specific membrane antigen with excellent LOD of 15 fg/mL for PSA and 4.8 fg/mL for PSMA were achieved in serum).…”

Section: Figure 38mentioning

confidence: 99%

Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications

Speranza

2021

Nanomaterials

175

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Recent advances in nanomaterial design and synthesis has resulted in robust sensing systems that display superior analytical performance. The use of nanomaterials within sensors has accelerated new routes and opportunities for the detection of analytes or target molecules. Among others, carbon-based sensors have reported biocompatibility, better sensitivity, better selectivity and lower limits of detection to reveal a wide range of organic and inorganic molecules. Carbon nanomaterials are among the most extensively studied materials because of their unique properties spanning from the high specific surface area, high carrier mobility, high electrical conductivity, flexibility, and optical transparency fostering their use in sensing applications. In this paper, a comprehensive review has been made to cover recent developments in the field of carbon-based nanomaterials for sensing applications. The review describes nanomaterials like fullerenes, carbon onions, carbon quantum dots, nanodiamonds, carbon nanotubes, and graphene. Synthesis of these nanostructures has been discussed along with their functionalization methods. The recent application of all these nanomaterials in sensing applications has been highlighted for the principal applicative field and the future prospects and possibilities have been outlined.

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“…They detected four proteins—CA-125, neuron-specific enolase (NSE), fragment antigen 21-1 (Cyfra21-1), and squamous cell carcinoma antigen (SCCA) at 0.0054 U mL −1 , 2.3 pg mL −1 , 5.5 pg mL −1 , and 4.8 pg mL −1 , respectively, using amperometric detection [ 122 ] ( Figure 9 ). Many other works, in label-free protein detection, have attained clinically-relevant detection limits, but they have only detected single biomarkers and improvements are required for multiplexing [ 123 , 124 , 125 , 126 ].…”

Section: Immunoassay Techniques For Printed Electrodesmentioning

confidence: 99%

Printed Electrodes in Microfluidic Arrays for Cancer Biomarker Protein Detection

et al. 2020

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Medical diagnostics is trending towards a more personalized future approach in which multiple tests can be digitized into patient records. In cancer diagnostics, patients can be tested for individual protein and genomic biomarkers that detect cancers at very early stages and also be used to monitor cancer progression or remission during therapy. These data can then be incorporated into patient records that could be easily accessed on a cell phone by a health care professional or the patients themselves on demand. Data on protein biomarkers have a large potential to be measured in point-of-care devices, particularly diagnostic panels that could provide a continually updated, personalized record of a disease like cancer. Electrochemical immunoassays have been popular among protein detection methods due to their inherent high sensitivity and ease of coupling with screen-printed and inkjet-printed electrodes. Integrated chips featuring these kinds of electrodes can be built at low cost and designed for ease of automation. Enzyme-linked immunosorbent assay (ELISA) features are adopted in most of these ultrasensitive detection systems, with microfluidics allowing easy manipulation and good fluid dynamics to deliver reagents and detect the desired proteins. Several of these ultrasensitive systems have detected biomarker panels ranging from four to eight proteins, which in many cases when a specific cancer is suspected may be sufficient. However, a grand challenge lies in engineering microfluidic-printed electrode devices for the simultaneous detection of larger protein panels (e.g., 50–100) that could be used to test for many types of cancers, as well as other diseases for truly personalized care.

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Enhanced performance of label-free electrochemical immunosensor for carbohydrate antigen 15-3 based on catalytic activity of cobalt sulfide/graphene nanocomposite

Cited by 71 publications

References 36 publications

Current and Prospective of Breast Cancer Biomarkers

Current and Prospective of Breast Cancer Biomarkers

Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications

Printed Electrodes in Microfluidic Arrays for Cancer Biomarker Protein Detection

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