Enhanced performance of Aloe vera incorporated chitosan-polyethylene oxide electrospun wound scaffold produced using novel Spirograph based collector assembly

Pathalamuthu, Pitchaimuthu; Siddharthan, A; Giridev, V.R.; Victoria, Victor; Thangam, Ramar; Srinivasan, Sivasubramanian; Savariar, Vincent; Hemamalini, T.

doi:10.1016/j.ijbiomac.2019.08.158

Cited by 30 publications

(17 citation statements)

References 31 publications

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“…These numbers indicated that PEO was more sensitive to the work solutions than PANI, and that PEO fibers were more hydrophilic than PEO films, maybe due to their higher surface area. Pathalamuthu et al reported angles less than 50° in PEO fibers in the presence of salts 47 . The results of this work are in the same direction; without salts, the angles were less than 10°, see Figure 6(a); with the salts of PBS solution, the angles increased up to 45°, see Figure 6(c); however, with the higher concentration of salts of the KR solution, the angles increased up to 60°, see Figure 6(b).…”

Section: Resultsmentioning

confidence: 99%

Hydrophilicity of electrospun microfibers of polyethylene oxide with semisoluble polyaniline for biological applications

Ramirez

Olayo

Palacios

et al. 2021

J of Applied Polymer Sci

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This work studies the hydrophilicity of electrospun microfibers of polyaniline (PANI) synthesized by plasma combined with polyethylene oxide (PEO). The hydrophilicity was evaluated measuring the contact angles of water, phosphate‐buffered saline (PBS) and Krebs‐Ringer (KR) biological solutions formed on the polymers. Plasma PANI is usually insoluble due to the crosslinking associated with the electrical discharges of the synthesis conditions; however, PANI was synthesized as semi‐soluble films, which were dissolved and mixed with soluble PEO to obtain PANI/PEO electrospun microfibers. Super‐hydrophilic (<30°) angles were obtained with water on PEO fibers and hydrophobic (>90°) angles were obtained with the PBS solution on PANI/PEO fibers. PANI films had contact angles, which increased with the salts of KR and PBS solutions, PEO films had sudden increments and reductions with the saline solutions. PANI showed the typical chemical groups of polyanilines and others as CN and CC associated with a high dehydrogenation, which disappeared in PANI fibers. Electromagnetic absorption peaks in the 270–320 nm wavelength range were detected in the fibers and not in the films, which can be associated with transitions between benzoid and quinoid PANI structures. These results indicated that PANI/PEO fibers would not dissolve as rapidly as PEO fibers in biological solutions.

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Section: Resultsmentioning

confidence: 99%

Hydrophilicity of electrospun microfibers of polyethylene oxide with semisoluble polyaniline for biological applications

Ramirez

Olayo

Palacios

et al. 2021

J of Applied Polymer Sci

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“…Pathalamuthu et al formulated chitosan-PEO hybrid nanofibers loaded with AV plant extract for wound care management [ 67 ]. The physicochemical properties of hybrid nanofibers were confirmed by FTIR and XRD analysis.…”

Section: Polymer-based Wound Dressings Scaffolds Enriched With Aloe Veramentioning

confidence: 99%

“…The in vitro antibacterial experiments of AV-enriched nanofibers showed superior antimicrobial effects against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ). The in vivo wound-healing experiments using full-thickness wound in Swiss Albino mice demonstrated complete wound closure on day 15 when dressed with AV extract-loaded nanofibers while wound treated with control completely closed on day 25 [ 67 ].…”

Section: Polymer-based Wound Dressings Scaffolds Enriched With Aloe Veramentioning

confidence: 99%

Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

et al. 2021

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The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

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“…Estudos têm demonstrado que o tratamento com extratos de gel de Aloe vera resultou na cicatrização mais rápida de feridas promovendo um efeito imunoestimulante ao ativar macrófagos (Oryan et al, 2010;Pathalamuthu et al, 2019). Ela também foi descrita para retardar o envelhecimento celular, para tratar acne, psoríase, radiação ultravioleta e lesões associadas à quimioterapia, bem como para cicatrização de feridas, por se apresentar como antisséptico, antibacteriano, antiinflamatório, antioxidante, anticâncer e com efeito imunomodulador (Pathalamuthu et al, 2019;Lima et al, 2020).…”

Section: Introductionunclassified

Desenvolvimento e caracterização de filmes curativos à base de mesocarpo de Attalea speciosa Mart. ex Spreng e extrato glicólico de Aloe vera (L.) Burm. f.

Araruna

Pereira

Brito

et al. 2021

RSD

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O amido de mesocarpo de babaçu (Attalea speciosa Mart. ex Spreng) e a Aloe vera (Aloe vera (L.) Burm. f.) são materiais naturais com vasta aplicação nas áreas de saúde. Neste trabalho de pesquisa foram preparados e caracterizados filmes casting compostos por amido de mesocarpo de babaçu suplementados com Aloe vera nas proporções de 0%, 5%, 8% e 10% observando características físicas de espessura, umidade, solubilidades em água, permeabilidade ao vapor de água e propriedades mecânicas. Além disso, foram avaliadas a citotoxicidade da solução filmogênica em macrófagos murinos da linhagem RAW 264.7 e células de hemácias humanas. Os resultados mostram que os filmes desenvolvidos têm superfície lisa, boa maleabilidade e são autossustentados. O teor de umidade, solubilidade e permeabilidade ao vapor de água aumentaram de acordo com o aumento da concentração de Aloe vera, para as propriedades mecânicas não houve diferença significativa (p>0,05) entre as formulações testadas. A solução filmogênica apresentou efeito citotóxico considerado seguro para os macrófagos e hemácias humanas. Essas características demonstram um bom potencial para cobertura de feridas e reparação tecidual.

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Enhanced performance of Aloe vera incorporated chitosan-polyethylene oxide electrospun wound scaffold produced using novel Spirograph based collector assembly

Cited by 30 publications

References 31 publications

Hydrophilicity of electrospun microfibers of polyethylene oxide with semisoluble polyaniline for biological applications

Hydrophilicity of electrospun microfibers of polyethylene oxide with semisoluble polyaniline for biological applications

Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Desenvolvimento e caracterização de filmes curativos à base de mesocarpo de Attalea speciosa Mart. ex Spreng e extrato glicólico de Aloe vera (L.) Burm. f.

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