Enhanced Osteoblast Responses to Poly(Methyl Methacrylate)/Hydroxyapatite Electrospun Nanocomposites for Bone Tissue Engineering

Xing, Zhicai; Han, Seog Young; Shin, Yong-Suk; Koo, Tae-Hyung; Moon, Sungmo; Jeong, Yongsoo; Kang, Inn‐Kyu

doi:10.1163/156856212x623526

Cited by 38 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In bone tissue engineering, the clinical needs for bone regeneration have motivated extensive research efforts using a multitude of polymers including polyethylene, 5 poly(ethylene glycol) (PEG), 6 poly(ε-caprolactone) (PCL), 7–8 poly(2-hydroxyethyl methacrylate) (pHEMA), 9 poly(methyl methacrylate) (PMMA), 10 poly( l -lactic acid) (PLLA), 11 poly(propylene fumarate) (PPF), 12,13 PPF- co -PCL and other copolymers. 14 PLLA and its copolymers have favorable chemical properties such as biodegradability through hydrolysis, physical properties such as high stiffness, and good efficiency in supporting bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Novel biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications

et al. 2015

View full text Add to dashboard Cite

Scaffolds with intrinsically interconnected porous structures are highly desirable in tissue engineering and regenerative medicine. In this study, three-dimensional polymer scaffolds with highly interconnected porous structures were fabricated by thermally induced phase separation of novel synthesized biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) in a dioxane/water binary system. Defined porous scaffolds were achieved by optimizing conditions to attain interconnected porous structures. The effect of phase separation parameters on scaffold morphology were investigated, including polymer concentration (1, 3, 5, 7, and 9%), quench time (1, 4, and 8 min), dioxane/water ratio (83/17, 85/15, and 87/13 wt/wt), and freeze temperature (−20, −80, and −196 °C). Interesting pore morphologies were created by adjusting these processing parameters, e.g., flower-shaped (5%; 85/15; 1 min; −80 °C), spherulite-like (5%; 85/15; 8 min; −80 °C), and bead-like (5%; 87/13; 1 min; −80 °C) morphology. Modulation of phase separation conditions also resulted in remarkable differences in scaffold porosities (81% to 91%) and thermal properties. Furthermore, scaffolds with varied mechanic strengths, degradation rates, and protein adsorption capabilities could be fabricated using the phase separation method. In summary, this work provides an effective route to generate multi-dimensional porous scaffolds that can be applied to a variety of hydrophobic polymers and copolymers. The generated scaffolds could potentially be useful for various tissue engineering applications including bone tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Novel biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Poly(e-caprolactone) [26][27][28] Low chemical versatility; degradable by hydrolysis or bulk erosion; slow degrading; bioresorbable Polymethylmethacrylate (PMMA) [29][30][31] Brittle; biocompatible; thermoplastic; low ductility; used as bone cement [54][55][56] Carbonaceous nanophase in a ceramic or polymer matrix 50,57 Better osteoconductivity; tailorable degradation rate; enhanced mechanical and biological properties; supporting cell activity Metallic nanophase in a ceramic or polymer matrix [58][59][60] Polymer-polymer composites 61,62 Abbreviations: 2D, two-dimensional; 3D, three-dimensional; UFG, ultrafine-grained; CNT, carbon nanotube; CNF, carbon nanofiber. 63 Current challenges are related to engineering materials that can match both the mechanical and biological context of real bone tissue matrix and support the vascularization of large tissue constructs while restoring its physiological function.…”

Section: Challenges In Bone Tissue Engineering and Requirementsmentioning

confidence: 99%

Nanomedicine applications in orthopedic medicine: state of the art

Mazaheri¹,

Eslahi²,

Ordikhani³

et al. 2015

IJN

View full text Add to dashboard Cite

The technological and clinical need for orthopedic replacement materials has led to significant advances in the field of nanomedicine, which embraces the breadth of nanotechnology from pharmacological agents and surface modification through to regulation and toxicology. A variety of nanostructures with unique chemical, physical, and biological properties have been engineered to improve the functionality and reliability of implantable medical devices. However, mimicking living bone tissue is still a challenge. The scope of this review is to highlight the most recent accomplishments and trends in designing nanomaterials and their applications in orthopedics with an outline on future directions and challenges.

show abstract

“…The necessity for tissue regeneration in the clinic has led to the production and testing of many polymers such as polyethylene, 9 poly( ε -caprolactone) (PCL), 10–12 poly(ethylene glycol) (PEG), 13 poly(L-lactic acid) (PLLA), 14 poly(methyl methacrylate) (PMMA), 15 and poly(propylene fumarate) (PPF). 16,17 Among these biodegradable polymers, PLLA and copolymers were acknowledged to have favorable biodegradability, high rigidity, and excellent tissue affinities without exhibiting inflammatory reactions in animal studies.…”

Section: Introductionmentioning

confidence: 99%

Tunable tissue scaffolds fabricated by in situ crosslink in phase separation system

et al. 2015

View full text Add to dashboard Cite

Three-dimensional (3-D) scaffolds with intrinsic porous structures are desirable in various tissue regeneration applications. In this study, a unique method that combines thermally induced phase separation with a photocrosslinking process was developed for the fabrication of 3-D crosslinked polymer scaffolds with densely interconnected porous structures. Biodegradable poly(propylene fumarate)-co-poly(L-lactic acid) with crosslinkable fumarate bonds were used as the structural polymer material and a dioxane/water binary system was applied for the phase separation. By altering the polymer composition (9, 5 and 3 wt%), different types of scaffolds with distinct morphology, mechanical strength, degradation rate, cell growth and morphology, and extracellular matrix production were fabricated. These crosslinked 3-D porous scaffolds with tunable strength and biological responses show promise for potential applications in regenerative therapies, including bone and neural tissue engineering.

show abstract

Enhanced Osteoblast Responses to Poly(Methyl Methacrylate)/Hydroxyapatite Electrospun Nanocomposites for Bone Tissue Engineering

Cited by 38 publications

References 31 publications

Novel biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications

Novel biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications

Nanomedicine applications in orthopedic medicine: state of the art

Tunable tissue scaffolds fabricated by in situ crosslink in phase separation system

Contact Info

Product

Resources

About