Enhanced Osseointegrative Properties of Ultra-Fine-Grained Titanium Implants Modified by Chemical Etching and Atomic Layer Deposition

Nazarov, D. V.; Смирнов, В. М.; Zemtsova, E. G.; Yudintceva, Natalia; Shevtsov, Maxim; Valiev, Ruslan Z.

doi:10.1021/acsbiomaterials.8b00342

Cited by 35 publications

(26 citation statements)

References 62 publications

(157 reference statements)

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“…Conformal titanium oxide nanocoatings, silver NPs, and structures combining coatings and NPs have been successfully prepared by ALD. According to a number of in vitro and in vivo studies, it is known that ALD titanium oxide films have a positive effect on the proliferation, differentiation and osseointegration of titanium implants [ 19 , 30 , 31 ]. According to our results, as-deposited ALD TiO 2 coatings have a less hydrophilic surface than polished titanium.…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial and Osteogenic Properties of Ag Nanoparticles and Ag/TiO2 Nanostructures Prepared by Atomic Layer Deposition

Nazarov

Ezhov

Yudintceva

et al. 2022

JFB

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The combination of titania nanofilms and silver nanoparticles (NPs) is a very promising material, with antibacterial and osseointegration-induced properties for titanium implant coatings. In this work, we successfully prepared TiO2 nanolayer/Ag NP structures on titanium disks using atomic layer deposition (ALD). The samples were studied by scanning electron microscopy (SEM), X-ray diffraction, X-ray photoelectron spectroscopy (XPS), contact angle measurements, and SEM-EDS. Antibacterial activity was tested against Staphylococcus aureus. The in vitro cytological response of MG-63 osteosarcoma and human fetal mesenchymal stem cells (FetMSCs) was examined using SEM study of their morphology, MTT test of viability and differentiation using alkaline phosphatase and osteopontin with and without medium-induced differentiation in the osteogenic direction. The samples with TiO2 nanolayers, Ag NPs, and a TiO2/Ag combination showed high antibacterial activity, differentiation in the osteogenic direction, and non-cytotoxicity. The medium for differentiation significantly improved osteogenic differentiation, but the ALD coatings also stimulated differentiation in the absence of the medium. The TiO2/Ag samples showed the best antibacterial ability and differentiation in the osteogenic direction, indicating the success of the combining of TiO2 and Ag to produce a multifunctional biocompatible and bactericidal material.

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Section: Discussionmentioning

confidence: 99%

“…The obtained UFG rods were treated by machining as described elsewhere [ 19 , 20 ]. First, the rods were cut into discs (thickness of 2–3 mm) with the Buehler IsoMet 1000 machine (Buehler, Lake Bluff, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

Antibacterial and Osteogenic Properties of Ag Nanoparticles and Ag/TiO2 Nanostructures Prepared by Atomic Layer Deposition

Nazarov

Ezhov

Yudintceva

et al. 2022

JFB

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“…Regarding the application to UFG CP Ti, Nazarov and co-workers [140] modified the surface of SPD-processed CP Ti with the combination of chemical etching (piranha solution) and a 20 nm thick ALD TiO2 coating showing that the oxide coating enhanced the adhesion of osteoblasts cells with respect to both the untreated and the etched Ti surfaces in in vitro tests. In a more recent work [141], the authors demonstrated in in vivo tests that the ALD treated surface presented higher bone formation and a higher level of osseointegration through removal torque tests than both the untreated and the etched Ti screws. Fully crystalline ALD anatase films (~ 100 nm) deposited on silicon substrate at 300 ºC by…”

Section: Biocompatibilitymentioning

confidence: 98%

Ultra-fine grained pure Titanium for biomedical applications

Mora-Sanchez

Sabirov

Monclús

et al. 2016

Materials Technology

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UltraFine-Grained Commercially Pure Titanium (UFG CP Ti) has arisen as one of the best prospects for the fabrication of implantable appliances due to the superior biocompatibility of CP Ti with respect to the other metallic systems used in the biomedical field, and to the enhanced mechanical properties provided by the refined microstructure obtained through Severe Plastic Deformation (SPD) processes. However, the bioinert character of CP Ti makes necessary to improve the osteoconductivity of the surface in order to ensure a rapid and successful osseointegration. Surface modification approaches including physical and/or chemical roughening and the fabrication of bioactive coatings have been shown to improve the cell adhesion and proliferation and osteoconductivity of CG and UFG CP Ti. In particular, the Plasma Electrolytic Oxidation (PEO) technique is one of the most promising approaches to fabricate thin TiO2-based Ca-and P-containing coatings. These type of coatings provide a suitable combination of surface topography and chemistry for applications that require osteoconductive properties. However, there is a relative lack of knowledge regarding the PEO treatment of UFG CP Ti in comparison with the significant body of research on the PEO treatment of CG CP Ti.The present Thesis is focused on the surface modification of UFG CP Ti to improve its osteoconductivity. The effect of the surface topography of chemically etched UFG CP Ti on the cell adhesion and proliferation was assessed. It was observed that the cell proliferation was dependent on the characteristics of the surface topography. The main body of the Thesis consisted on the fabrication of PEO coatings on both CG and UFG CP Ti using three different electrolytes, one of them aimed to produce Ca-and P-containing coatings. The main objective of this study was twofold: First, to compare the resulting corrosion resistance, cell-surface interaction, and mechanical properties of the three PEO treatments; and second, to compare the applicability of the PEO treatment and the coatings obtained on both CG and UFG CP Ti. The UFG microstructure was found to influence the coatings growth rate, the discharge generation of each treatment and the microstructure of the layers in intimate contact with the substrate. At the same time, the latter was found to cause significant differences in the corrosion behaviour between the CG CP Ti-coated and the UFG CP Ti-coated samples. The mechanical performance of the coatings was strongly dependent on the microstructure of the outer layers of the coatings. The Ca-and P-containing coating fabricated for 120 s on the UFG CP Ti presented the highest celular proliferation rate and metabolic activity showing potential for osteoinductive and osteoconductive capabilities. In order to improve the mechanical performance of the coatings an alternative approach to the common methods for hardening of PEO coatings was proposed.

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“…Moreover, SALD can be sensitive to ambient air if performed in open air, highly volatile precursors are needed for SALD, and, The thin film deposition technique of ALD has a wide range of applications [3,5,9,10]. Some of the important applications of ALD include but are not limited to the following areas: semiconductor engineering [11][12][13], lithium-ion batteries [14][15][16], microelectromechanical systems (MEMS) [17,18], capacitors [19,20], fuel cells [21][22][23], solar cells [24][25][26], transistors [27][28][29], drug delivery [30,31], medical and biomedical fields [32][33][34][35], dental materials [6,10], and orthopedical implants [36][37][38]. Due to the capability of precisely depositing conformal ultra-thin films, ALD has found a wide range of applications in the fabrication of microelectronics such as gate oxides, semiconductors, and ferroelectrics [12,39,40].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Theoretical Development of Thermal Atomic Layer Deposition: A Review

et al. 2022

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Atomic layer deposition (ALD) is a vapor-phase deposition technique that has attracted increasing attention from both experimentalists and theoreticians in the last few decades. ALD is well-known to produce conformal, uniform, and pinhole-free thin films across the surface of substrates. Due to these advantages, ALD has found many engineering and biomedical applications. However, drawbacks of ALD should be considered. For example, the reaction mechanisms cannot be thoroughly understood through experiments. Moreover, ALD conditions such as materials, pulse and purge durations, and temperature should be optimized for every experiment. It is practically impossible to perform many experiments to find materials and deposition conditions that achieve a thin film with desired applications. Additionally, only existing materials can be tested experimentally, which are often expensive and hazardous, and their use should be minimized. To overcome ALD limitations, theoretical methods are beneficial and essential complements to experimental data. Recently, theoretical approaches have been reported to model, predict, and optimize different ALD aspects, such as materials, mechanisms, and deposition characteristics. Those methods can be validated using a different theoretical approach or a few knowledge-based experiments. This review focuses on recent computational advances in thermal ALD and discusses how theoretical methods can make experiments more efficient.

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Enhanced Osseointegrative Properties of Ultra-Fine-Grained Titanium Implants Modified by Chemical Etching and Atomic Layer Deposition

Cited by 35 publications

References 62 publications

Antibacterial and Osteogenic Properties of Ag Nanoparticles and Ag/TiO2 Nanostructures Prepared by Atomic Layer Deposition

Antibacterial and Osteogenic Properties of Ag Nanoparticles and Ag/TiO2 Nanostructures Prepared by Atomic Layer Deposition

Ultra-fine grained pure Titanium for biomedical applications

Recent Advances in Theoretical Development of Thermal Atomic Layer Deposition: A Review

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