Enhanced osseointegration of Ti6Al4V ELI screws built-up by electron beam additive manufacturing: An experimental study in rabbits

Lee, Byoung-Soo; Lee, Hae-Jin; Lee, Kang-Sik; Kim, Hyung Giun; Kim, Gun-Hee; Lee, Chang-Woo

doi:10.1016/j.apsusc.2019.145160

Cited by 33 publications

(18 citation statements)

References 32 publications

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“…Titanium and its alloys, most notably Ti‐6Al‐4V (Ti64), are popular materials for implants and in biomedical applications. Titanium is utilized as a biomaterial for many of its attributes including but not limited to its excellent biocompatibility, corrosion resistance, and beneficial mechanical properties 16‐18 . However, a couple of concerns that arise with titanium implants are the phenomenon of stress‐shielding due to titanium's high elastic modulus compared to natural bone and also being bioinert 17,19,20 .…”

Section: Introductionmentioning

confidence: 99%

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

2021

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As life expectancy and the age of the general population increases so does the need for improved implants. A major contributor to the failure of implants is poor osseointegration, which is typically described as the direct connection between bone and implant. This leads to unnecessary complications and an increased burden on the patient population. Modification of the implant surfaces through novel techniques, such as varying topography and/or applying coatings, has become a popular method to enhance the osseointegration capability of implants. Recent research has shown that particular surface features influence how bone cells interact with a material; however, it is unknown which exact features achieve optimal bone integration. In this review, current methods of modifying surfaces will be highlighted, and the resulting surface characteristics and biological responses are discussed. Review of the current strategies of surface modifications found that many coating types are more advantageous when used in combination; however, finding a surface modification that utilizes the mutual beneficial effects of important surface characteristics while still maintaining commercial viability is where future challenges exist.

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Section: Introductionmentioning

confidence: 99%

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

2021

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“…To date, numerous studies have been carried out by different research teams to prove the suitability of these processes in implant production [8][9][10][11]. The example of already applied EBM-manufactured implants are replacements of acetabular cups, which have gained approval from United States Food and Drug Administration (FDA) and are CE-certified (Conformité Européenne) since 2007 and 2010, respectively [3].…”

Section: Introductionmentioning

confidence: 99%

The Impact of EBM-Manufactured Ti6Al4V ELI Alloy Surface Modifications on Cytotoxicity toward Eukaryotic Cells and Microbial Biofilm Formation

et al. 2020

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Electron beam melting (EBM) is an additive manufacturing technique, which allows forming customized implants that perfectly fit the loss of the anatomical structure of bone. Implantation efficiency depends not only on the implant’s functional or mechanical properties but also on its surface properties, which are of great importance with regard to such biological processes as bone regeneration or microbial contamination. This work presents the impact of surface modifications (mechanical polishing, sandblasting, and acid-polishing) of EBM-produced Ti6Al4V ELI implants on essential biological parameters. These include wettability, cytotoxicity toward fibroblast and osteoblast cell line, and ability to form biofilm by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Obtained results indicated that all prepared surfaces exhibited hydrophilic character and the highest changes of wettability were obtained by chemical modification. All implants displayed no cytotoxicity against osteoblast and fibroblast cell lines regardless of the modification type. In turn, the quantitative microbiological tests and visualization of microbial biofilm by means of electron microscopy showed that type of implant’s modification correlated with the species-specific ability of microbes to form biofilm on it. Thus, the results of the presented study confirm the relationship between such technological aspects as surface modification and biological properties. The provided data are useful with regard to applications of the EBM technology and present a significant step towards personalized, customized implantology practice.

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“…Additive manufacturing technology can be divided into metal additive manufacturing and nonmetal additive manufacturing according to different materials. According to the types of heat sources, metal additive manufacturing mainly includes laser additive manufacturing, electron beam additive manufacturing, plasma additive manufacturing, and wire arc additive manufacturing (WAAM) [10][11][12][13][14][15]. Compared with other additive manufacturing technologies, WAAM technology has a high production efficiency and the ability to fabricate large parts.…”

Section: Introductionmentioning

confidence: 99%

Microstructure and Properties of a 2.25Cr1Mo0.25V Heat‐Resistant Steel Produced by Wire Arc Additive Manufacturing

Guo

Liu

et al. 2020

Advances in Materials Science and Engineering

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Wire arc additive manufacturing (WAAM) technology was used to produce samples of a 2.25Cr1Mo0.25V heat-resistant steel. The phase composition, microstructure, and crystal structure of the investigated material in the as-cladded state and postcladding heat-treated (705°C × 1 h) state were analysed by optical emission spectrometry (OES), optical microscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The properties of the investigated material in the as-cladded state and postcladding heat-treated (705°C × 1 h) state were determined by a microhardness tester, mechanical properties tester, and Charpy impact tester. Through a study of the microstructure and properties, it is found that the investigated material produced by WAAM exhibits good forming quality and excellent metallurgical bonding properties, and no obvious defects are found. The microstructure consists mainly of Bg (granular bainite) and troostite precipitated at the grain boundaries. The results from high-resolution transmission electron microscopy observations show that the crystal structures of the 2.25Cr1Mo0.25V heat-resistant steel samples produced by WAAM in the as-cladded condition have many defects, such as dislocations and martensite-austenite (M-A) constituents, and their grain edges are sharp. There is a dramatic decrease in the dislocations in the 2.25Cr1Mo0.25V heat-resistant steel samples produced by the WAAM condition after the postcladding heat treatment (705°C × 1 h), and the grains become smooth. The distribution of the microhardness in the longitudinal and transverse cross sections of the samples is very uniform. The average longitudinal and transverse microhardness of the samples in the as-cladded state is 310 HV0.5 and 324 HV0.5, respectively. The average longitudinal and transverse microhardness of the samples after post-cladding heat treatment is 227 HV0.5 and 229 HV0.5, respectively. The yield strength of the samples without a postcladding heat treatment is 743 MPa, the tensile strength is 951 MPa, the elongation is 10%, and the Charpy impact value at -20°C is 15 J. After the postcladding heat treatment, the yield strength, tensile strength, elongation, and Charpy impact value of the samples are 611 MPa, 704 MPa, 14.5%, and 70 J, respectively.

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Enhanced osseointegration of Ti6Al4V ELI screws built-up by electron beam additive manufacturing: An experimental study in rabbits

Cited by 33 publications

References 32 publications

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

Surface modifications to enhance osseointegration–Resulting material properties and biological responses

The Impact of EBM-Manufactured Ti6Al4V ELI Alloy Surface Modifications on Cytotoxicity toward Eukaryotic Cells and Microbial Biofilm Formation

Microstructure and Properties of a 2.25Cr1Mo0.25V Heat‐Resistant Steel Produced by Wire Arc Additive Manufacturing

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