Enhanced Oromucosal Delivery of Progesterone Via Hexosomes

Swarnakar, Nitin K.; Jain, Vikas; Dubey, Vaibhav; Mishra, Dinesh Kumar; Jain, Narendra Kumar

doi:10.1007/s11095-007-9409-y

Cited by 92 publications

(43 citation statements)

References 46 publications

(38 reference statements)

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“…The concentration of Pluronic ® F68 was also found to have a significant effect on the gelation temperature of the gelling system. The formulations containing 18 (50). This was the main reason for selecting the concentrations of Pluronic ® F127 (20% w/v) and Pluronic ® F68 (18% w/v) for further study and formulation of the depot system.…”

Section: Discussionmentioning

confidence: 99%

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Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

et al. 2015

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Abstract. The aim of the present study was to develop and evaluate a thermoresponsive depot system comprising of docetaxel-loaded cubosomes. The cubosomes were dispersed within a thermoreversible gelling system for controlled drug delivery. The cubosome dispersion was prepared by dilution method, followed by homogenization using glyceryl monooleate, ethanol and Pluronic ® F127 in distilled water. The cubosome dispersion was then incorporated into a gelling system prepared with Pluronic ® F127 and Pluronic ® F68 in various ratios to formulate a thermoresponsive depot system. The thermoresponsive depot formulations undergo a thermoreversible gelation process i.e., they exists as free flowing liquids at room temperature, and transforms into gels at higher temperatures e.g., body temperature, to form a stable depot in aqueous environment. The mean particle size of the cubosomes in the dispersion prepared with Pluronic ® F127, with and without the drug was found to be 170 and 280 nm, respectively. The prepared thermoresponsive depot system was evaluated by assessing various parameters like time for gelation, injectability, gel erosion, and in-vitro drug release. The drug-release studies of the cubosome dispersion before incorporation into the gelling system revealed that a majority (∼97%) of the drug was released within 12 h. This formulation also showed a short lag time (∼3 min). However, when incorporated into a thermoresponsive depot system, the formulation exhibited an initial burst release of ∼21%, and released only ∼39% drug over a period of 12 h, thus indicating its potential as a controlled drug delivery system.

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Section: Discussionmentioning

confidence: 99%

“…The feasibility of cubosomes as carriers for parenteral, topical, and buccal delivery of drugs has been reported in the literature (14)(15)(16)(17)(18)(19). Formulations based on this technology have been reported to have improved tolerance and drug bioavailability (20).…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

et al. 2015

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“…It is important to understand the structural characteristics of the buccal mucosa as mucosa can act as a physical barrier in the transbuccal drug delivery, and its physical features are closely related to the permeation mechanisms [37]. With FT-IR spectroscopy, it is possible to know the status of a lipid bilayer, whether it is in the gel state (ordered) or the sol state (fluidized) [38].…”

Section: Ft-ir Spectroscopic Studymentioning

confidence: 99%

“…The prominent peaks near 2,850 and 2,920 cm −1 represent the symmetric and asymmetric carbon-hydrogen (C-H) stretching, respectively [37]. The increase of fluidized lipids in the buccal mucosa can be explained by the following mechanisms: i) there is an increase of the gauche conformers within the lipid hydrocarbon chains, which results in increasing wave number in the symmetric and asymmetric C-H stretching absorbance peaks [39], ii) there is enhanced fluidity in the lipid acyl chains, which causes a broadening of the C-H stretching absorbance peaks [38].…”

Section: Ft-ir Spectroscopic Studymentioning

confidence: 99%

Strategic Approaches for Enhancement of In Vivo Transbuccal Peptide Drug Delivery in Rabbits using Iontophoresis and Chemical Enhancers

Kim

Jeon

et al. 2014

Pharm Res

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“…27 There have been many attempts at improving DNA transfection by rational design of transfection agents. A recent example is an X-ray SAD study of gemini surfactant based nanoparticles incorporated with DNA, whereby the nanoparticles form weakly ordered structures and multiple phases.…”

mentioning

confidence: 99%

Neutron and X-ray scattering for biophysics and biotechnology: examples of self-assembled lipid systems

et al. 2009

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Membranes that surround cells and separate their contents from the external environment are ubiquitous in biological systems. These membranes are organized assemblies consisting mainly of lipids and proteins, and are highly selective permeability barriers which control the flow of information between cells and their environment. It is accepted that the lipid bilayer is the underlying structure of most, if not all, biomembranes. As such, over the years scientists have exerted much effort in studying lipid bilayers and their biological relevance in hopes of understanding the functional mechanisms taking place at membrane interfaces. Neutron and X-ray scattering techniques are powerful tools for the characterization of the structure and dynamics of biomimetic systems as they provide unique access to microscopic structure and dynamics at length scales ranging from microns to intermolecular and/or atomic distances. The optimization of instruments and preparation techniques, as well as the new possibilities offered by protein deuteration, have opened up new avenues for the study of lipid/protein interactions that were not previously possible. One can now look at the insertion of biomolecules into membranes and accurately determine the structure as well as the dynamics of the interaction. To illustrate the usefulness of diffraction and scattering techniques with regard to biologically relevant systems, we review some of the leading edge studies that have taken place over the last couple of years in which these scattering techniques have played a central role.

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Enhanced Oromucosal Delivery of Progesterone Via Hexosomes

Abstract: Developed hexosomes formulation exhibited high entrapment efficiency, high permeability and better stability on storage, thus proposing itself a novel carrier for enhanced oromucosal delivery of progesterone.

Cited by 92 publications

References 46 publications

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

Strategic Approaches for Enhancement of In Vivo Transbuccal Peptide Drug Delivery in Rabbits using Iontophoresis and Chemical Enhancers

Neutron and X-ray scattering for biophysics and biotechnology: examples of self-assembled lipid systems

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