Enhanced localized surface plasmon resonance sensing on three-dimensional gold nanoparticles assemblies

Ye, Jian; Bonroy, Kristien; Nelis, Daniel; Frederix, Filip; D’Haen, Jan; Maes, Guido; Borghs, Gustaaf

doi:10.1016/j.colsurfa.2008.01.028

Cited by 63 publications

(53 citation statements)

References 17 publications

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“…By changing the surrounding RI of the nanoparticles, a red-shift of the peak position and an increase of the maximum absorbance occur. These variations in microfluidic condition are in good agreement with the previously reported results measured in cuvette statically, without the microfluidic chip (Ye et al 2008). Furthermore, if we make a vertical line along 530 nm wavelength, plot the absorbance intensities of the intersections of the spectra and the 530 nm line as a function of surrounding RI, a good linear relationship between them was determined as shown in Fig.…”

Section: Characterization Of the Microfluidic Integrated Biosensorsupporting

confidence: 72%

Localized surface plasmon resonance biosensor integrated with microfluidic chip

Huang

Bonroy

Reekmans

et al. 2009

Biomed Microdevices

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A sensitive and low-cost microfluidic integrated biosensor is developed based on the localized surface plasmon resonance (LSPR) properties of gold nanoparticles, which allows label-free monitoring of biomolecular interactions in real-time. A novel quadrant detection scheme is introduced which continuously measures the change of the light transmitted through the nanoparticle-coated sensor surface. Using a green light emitting diode (LED) as a light source in combination with the quadrant detection scheme, a resolution of 10(-4) in refractive index units (RIU) is determined. This performance is comparable to conventional LSPR-based biosensors. The biological sensing is demonstrated using an antigen/antibody (biotin/anti-biotin) system with an optimized gold nanoparticle film. The immobilization of biotin on a thiol-based self-assembled monolayer (SAM) and the subsequent affinity binding of anti-biotin are quantitatively detected by the microfluidic integrated biosensor and a detection limit of 270 ng/mL of anti-biotin was achieved. The microfluidic chip is capable of transporting a precise amount of biological samples to the detection areas to achieve highly sensitive and specific biosensing with decreased reaction time and less reagent consumption. The obtained results are compared with those measured by a surface plasmon resonance (SPR)-based Biacore system for the same binding event. This study demonstrates the feasibility of the integration of LSPR-based biosensing with microfluidic technologies, resulting in a low-cost and portable biosensor candidate compared to the larger and more expensive commercial instruments.

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Section: Characterization Of the Microfluidic Integrated Biosensorsupporting

confidence: 72%

Localized surface plasmon resonance biosensor integrated with microfluidic chip

Huang

Bonroy

Reekmans

et al. 2009

Biomed Microdevices

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“…Whereas surface-based plasmonic nanosensors are often constructed using two-dimensionally assembled nanostructures [137][138][139], three-dimensional (3D) assembly of metallic nanostructures has been reported to achieve a significant improvement in the detection sensitivity of plasmonic nanosensors [140][141][142][143][144]. A layer-bylayer (LbL) self-assembly technique was used to fabricate a multilayered Au NP structure on quartz, leading to a four-fold improvement in the sensitivity compared with a monolayered nanosensor [145]. However, the LbL selfassembly technique typically generates a compact assembly of nanoparticles, which inherently causes serious plasmonic coupling between neighbouring nanoparticles.…”

Section: Figurementioning

confidence: 99%

Strategies for enhancing the sensitivity of plasmonic nanosensors

et al. 2015

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Based on the localized surface plasmon resonance (LSPR) of metallic nanoparticles, plasmonic nanosensors have emerged as a powerful tool for biosensing applications. Many detection schemes have been developed and the field is rapidly growing to incorporate new methodologies and applications. Amidst all the ongoing research efforts, one common factor remains a key driving force: continued improvement of high-sensitivity detection. Although there are many excellent reviews available that describe the general progress of LSPR-based plasmonic biosensors, there has been limited attention to strategies for improving the sensitivity of plasmonic nanosensors. Recognizing the importance of this subject, this review highlights recent progress on different strategies used for improving the sensitivity of plasmonic nanosensors. These strategies are classified into the following three categories based on their different sensing mechanisms: (1) sensing based on target-induced local refractive index changes, (2) colorimetric sensing based on LSPR coupling, and (3) amplification of detection sensitivity based on nanoparticle growth. The basic principles and cutting-edge examples are provided for each kind of strategy, collectively forming a unifying framework to view the latest attempts to improve the sensitivity of nanoplasmonic sensors. Future trends for the fabrication of improved plasmonic nanosensors are also discussed.

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“…Furthermore, Ye et al [8] found that the number of gold nanoparticle deposition cycles has a strong effect on the sensitivity of the sensor and the multilayer structure fabricated from four nanoparticle deposition cycles exhibits maximum sensitivity to the change of the environmental refractive index. By using accurate electrodynamic simulations of gold nanoparticles of significant size parameters, Miller and Lazarides [9] have demonstrated that the sensitivity of a plasmon peak wavelength to a variation in refractive index of the environment is determined by the location of the peak wavelength and the dielectric properties of the material.…”

Section: Introductionmentioning

confidence: 98%

“…It is demonstrated that both the intensity and resonance wavelength of LSPR are controlled by the local environment [1][2][3][4], which provides possibility for the design and fabrication of ultrasensitive chemical and biological sensors [5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%