Enhanced Initial Cell Responses to Chemically Modified Anodized Titanium

Jimbo, Ryo; Saeki, Takashi; Baba, Koumei; Kurogi, Tadafumi; Shibata, Yasuaki; Atsuta, Mitsuru

doi:10.1111/j.1708-8208.2007.00061.x

Cited by 64 publications

(60 citation statements)

References 24 publications

(34 reference statements)

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“…Atsuta et al . reported hydrophilicity is improved after treatment with NH 4 F [57]; however, fluorine is thermally decomposed during annealing [5], [58]–[60] and cannot be responsible for hydrophilicity of annealed surfaces. Crystallinity and morphology are the factors that control surface hydrophilicity.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Anti-Aging TiO2 Nanotubes on Biomedical Ti Alloys

et al. 2014

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The primary objective of this study was to fabricate a TiO2 nanotubular surface, which could maintain hydrophilicity over time (resist aging). In order to achieve non-aging hydrophilic surfaces, anodization and annealing conditions were optimized. This is the first study to show that anodization and annealing condition affect the stability of surface hydrophilicity. Our results indicate that maintenance of hydrophilicity of the obtained TiO2 nanotubes was affected by anodization voltage and annealing temperature. Annealing sharply decreased the water contact angle (WCA) of the as-synthesized TiO2 nanotubular surface, which was correlated to improved hydrophilicity. TiO2 nanotubular surfaces are transformed to hydrophilic surfaces after annealing, regardless of annealing and anodization conditions; however, WCA measurements during aging demonstrate that surface hydrophilicity of non-anodized and 20 V anodized samples decreased after only 11 days of aging, while the 60 V anodized samples maintained their hydrophilicity over the same time period. The nanotubes obtained by 60 V anodization followed by 600 °C annealing maintained their hydrophilicity significantly longer than nanotubes which were obtained by 60 V anodization followed by 300 °C annealing.

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Section: Discussionmentioning

confidence: 99%

Fabrication of Anti-Aging TiO2 Nanotubes on Biomedical Ti Alloys

et al. 2014

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“…Since the implant surface is the first part to interact with the host, it has been thoroughly investigated in an attempt to hasten the early host-to-implant response [14,15]. The rationale for its modification focuses upon implant interaction with biofluids, which positively alters the cascade of events leading to bone healing and intimate interaction with the surface [16]. Numerous possibilities have been suggested and evaluated for this purpose [17–19]; however, there is no consensus concerning which kinds of surface roughness and/or chemistry combination will result in optimum osseointegration [20–22].…”

Section: Surface Treatmentmentioning

confidence: 99%

Plasma in dentistry

Cha

Park

2014

Clinical Plasma Medicine

125

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This review describes the contemporary aspects of plasma application in dentistry. Previous studies on plasma applications were classified into two categories, surface treatment and direct applications, and were reviewed, respectively according to the approach. The current review discussed modification of dental implant surface, enhancing of adhesive qualities, enhancing of polymerization, surface coating and plasma cleaning under the topics of surface treatment. Microbicidal activities, decontamination, root canal disinfection and tooth bleaching were reviewed as direct applications with other miscellaneous ones. Non-thermal atmospheric pressure plasma was of particular focus since it is gaining considerable attention due to the possibility for its use in living tissues. Future perspectives have also been discussed briefly. Although it is still not popular among dentists, plasma has shown promises in several areas of dentistry and is now opening a new era of plasma dentistry.

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“…The ability to better adhere and spread the recruited cells to the implant surface has been proven to be an essential factor for the subsequent osteogenic events [18], [19]. It has been shown in vitro that nanotextured surfaces influence the cell morphology of the adhered osteoblasts [20], [26].…”

Section: Introductionmentioning

confidence: 99%

Nanometer Scale Titanium Surface Texturing Are Detected by Signaling Pathways Involving Transient FAK and Src Activations

et al. 2014

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BackgroundIt is known that physico/chemical alterations on biomaterial surfaces have the capability to modulate cellular behavior, affecting early tissue repair. Such surface modifications are aimed to improve early healing response and, clinically, offer the possibility to shorten the time from implant placement to functional loading. Since FAK and Src are intracellular proteins able to predict the quality of osteoblast adhesion, this study evaluated the osteoblast behavior in response to nanometer scale titanium surface texturing by monitoring FAK and Src phosphorylations.MethodologyFour engineered titanium surfaces were used for the study: machined (M), dual acid-etched (DAA), resorbable media microblasted and acid-etched (MBAA), and acid-etch microblasted (AAMB). Surfaces were characterized by scanning electron microscopy, interferometry, atomic force microscopy, x-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy. Thereafter, those 4 samples were used to evaluate their cytotoxicity and interference on FAK and Src phosphorylations. Both Src and FAK were investigated by using specific antibody against specific phosphorylation sites.Principal FindingsThe results showed that both FAK and Src activations were differently modulated as a function of titanium surfaces physico/chemical configuration and protein adsorption.ConclusionsIt can be suggested that signaling pathways involving both FAK and Src could provide biomarkers to predict osteoblast adhesion onto different surfaces.

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Enhanced Initial Cell Responses to Chemically Modified Anodized Titanium

Abstract: ABSTRACT:Background: Previously, we reported that anodized porous titanium implants have

Cited by 64 publications

References 24 publications

Fabrication of Anti-Aging TiO2 Nanotubes on Biomedical Ti Alloys

Fabrication of Anti-Aging TiO2 Nanotubes on Biomedical Ti Alloys

Plasma in dentistry

Nanometer Scale Titanium Surface Texturing Are Detected by Signaling Pathways Involving Transient FAK and Src Activations

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