Enhanced inhibitory avoidance training protects against the amnesic effect of p–chloroamphetamine

Solana‐Figueroa, Rafael; Salado‐Castillo, Rigoberto; Quírarte, Gina L.; Galindo, Lauro Bucio; Prado-Alcalá, Roberto A.

doi:10.1016/s0024-3205(02)01684-3

Cited by 21 publications

(8 citation statements)

References 36 publications

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“…It is possible, therefore, that the higher number of footshocks used in the present study could enhance the association strength between the contextual CS and the US. Previous studies have shown that the intensity of the aversive stimulus during training can interfere with the amnesic effect of drugs on consolidation (Cruz-Morales, Duran-Arevalo, Diaz Del Guante, Quirarte, & Prado-Alcala, 1992; Solana-Figueroa, Salado-Castillo, Quirarte, Galindo, & Prado-Alcala, 2002). Independent of such possibilities, the results obtained in this study with icv administrations show that N/OFQ, at the same dose range that impairs acquisition, does not interfere with the consolidation of CFC and TFC.…”

Section: Discussionmentioning

confidence: 99%

Effects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in rats.

Fornari

Soares

Ferreira

et al. 2008

Behavioral Neuroscience

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Nociceptin, or orphanin FQ (N/OFQ), the endogenous ligand of NOP receptors, is known to regulate learning and memory processes. To verify the role of N/OFQ in the acquisition of contextual (CFC) and tone fear conditioning (TFC), Wistar male rats received intracerebroventricular injections of N/OFQ (0.1-5.0 nmol) before training, and were tested 24 and 48 hr later to access the freezing response to context and tone, respectively. The intermediate doses (1.0 and 2.5 nmol) impaired the CFC test, sparing TFC. The highest dose (5.0 nmol) reduced freezing during both tests, a result that may be due to nonspecific effects. The posttraining injection of N/OFQ (1 or 5 nmol) did not interfere with CFC and TFC, suggesting a specific effect of the peptide in acquisition processes. Moreover, the impairment observed with N/OFQ (1 nmol) in CFC cannot be attributed to a state-dependent learning because it was not reversed by its pretest administration. The data support the negative role of N/OFQ in the acquisition of aversively motivated tasks, which encompass a spatial component and depend on the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Effects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in rats.

Fornari

Soares

Ferreira

et al. 2008

Behavioral Neuroscience

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“…Although amnestic influences have been rarely studied in experiments using intensive training, the available findings have consistently indicated that amnestic treatments become ineffective or less effective when animals are extensively trained or given relatively high intensities of foot‐shock for training (Prado‐Alcalá et al, ). This effect has been observed after systemic administration of amnestic treatments (Durán‐Arévalo et al, ; Cruz‐Morales et al, ; Solana‐Figueroa et al, ; Díaz‐Trujillo et al, ) as well as localized treatments affecting the striatum (STR), amygdala (AMY), substantia nigra (SN), and hippocampus, among other cerebral structures (Thatcher and Kimble, ; Prado‐Alcalá and Cobos‐Zapiaín, , ; Prado‐Alcalá et al, ; Parent et al, , ; Cobos‐Zapiaín et al, ; Lazaro‐Muñoz et al, ). Such findings have been interpreted as suggesting that the affected structures are not critical sites for the changes mediating associations based on overtraining or strong aversive stimulation, which engages other brain regions subserving memory processing.…”

Section: Introductionmentioning

confidence: 96%

Intense aversive training protects memory from the amnestic effects of hippocampal inactivation

et al. 2013

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There is extensive evidence that amnestic treatments are less effective, or ineffective when administered to subjects that have been overtrained or subjected to high foot-shock intensities in aversively motivated learning. This protective effect has been found with a variety of learning tasks and with treatments that disrupt activity in several regions of the brain, including the hippocampus, amygdala, striatum, and substantia nigra. Such findings have been interpreted as suggesting that the brain regions disrupted are not critical sites for the memory processes induced by these types of training. In most experiments investigating this issue the amnestic treatments were administered after training. Thus, it might be less amnesia was induced because the training accelerated memory consolidation and, thus, the maximum effect of the amnestic treatment occurred after memory of the learning experience was consolidated. This study investigated this issue by inactivating the hippocampus of rats bilaterally with tetrodotoxin (TTX) (10 ng/side) 30 min before one-trial inhibitory avoidance training using relatively low (1.0 mA), medium (2.0 mA), or high (3.0 mA) foot-shock intensities. Retention of the task was measured 48 h after training. TTX produced a profound retention deficit, a mild deficit, and no deficit at all in the 1.0, 2.0, and 3.0 mA groups, respectively. These data confirm the protective effect of training with relatively high foot-shock intensity against experimentally induced amnesia, and suggests that this protection is not due to accelerated consolidation. Rather, the findings suggest that strong training activates brain systems other than those typically involved in mediating memory consolidation.

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“…In spite of the abundant literature regarding the effects of systemic administration of serotonergic drugs on memory (e.g., Altman and Normile, 1987;Archer, 1982;Meneses, 1999Meneses, , 2002Misane et al, 1998;Ö gren, 1982, 1986aSolana-Figueroa et al, 1999, 2002b, there is a conspicuous scarcity of reports regarding the cognitive effects of their central administration. It is reasonable to postulate that serotonin (5-HT) must interact with other neurotransmitters in those cerebral regions known to participate in cognition.…”

Section: Introductionmentioning

confidence: 99%

Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats

et al. 2003

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Enhanced inhibitory avoidance training protects against the amnesic effect of p–chloroamphetamine

Cited by 21 publications

References 36 publications

Effects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in rats.

Effects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in rats.

Intense aversive training protects memory from the amnestic effects of hippocampal inactivation

Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats

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