Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats

Prado-Alcalá, Roberto A.; Solana‐Figueroa, Rafael; Galindo, Lauro Bucio; Medina, Andrea C.; Quírarte, Gina L.

doi:10.1016/j.lfs.2003.06.012

Cited by 24 publications

(8 citation statements)

References 31 publications

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“…DOI could interfere with retrieval processes in experienced mice. However, several studies have revealed that 5-HT 2A receptor agonists such as DOI improve memory and facilitate learning consolidation (Meneses and Hong 1999;Meneses 2002Williams et al 2002Prado-Alcala et al 2003).…”

Section: Discussionmentioning

confidence: 99%

The four-plates test–retest paradigm to discriminate anxiolytic effects

Ripoll¹,

Dhonnchadha²,

Sébille

et al. 2005

Psychopharmacology

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Section: Discussionmentioning

confidence: 99%

The four-plates test–retest paradigm to discriminate anxiolytic effects

Ripoll¹,

Dhonnchadha²,

Sébille

et al. 2005

Psychopharmacology

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“…Serotonin is described as necessary to establish normal long-term potentiation ( LTP ) in invertebrate and mammalian models (Kandel, 2004; Kim, et al, 2006), and is thought to be responsible for inhibitory control in the establishment of LTP in hippocampal-PFC circuits (Ohashi, et al, 2003). At present, a role is suggested for the 5-HT 2 R family in cortical LTP (Edagawa, et al, 2000; Inaba, et al, 2009) and in the acquisition, consolidation and retrieval of learned behaviors, especially in those engendered in simple memory models (e.g., autoshaping tasks) (Meneses, 2007; Prado-Alcala, et al, 2003). Serotonin is in fact required to recruit protein synthesis and synaptic growth thought to underlie long-term memory (Bailey, et al, 2000).…”

Section: Future Directionsmentioning

confidence: 99%

Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction

2014

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Cocaine abuse and addiction remain great challenges on the public health agendas in the U.S. and the world. Increasingly sophisticated perspectives on addiction to cocaine and other drugs of abuse have evolved with concerted research efforts over the last 30 years. Relapse remains a particularly powerful clinical problem as, even upon termination of drug use and initiation of abstinence, the recidivism rates can be very high. The cycling course of cocaine intake, abstinence and relapse is tied to a multitude of behavioral and cognitive processes including impulsivity (a predisposition toward rapid unplanned reactions to stimuli without regard to the negative consequences), and cocaine cue reactivity (responsivity to cocaine-associated stimuli) cited as two key phenotypes that contribute to relapse vulnerability even years into recovery. Preclinical studies suggest that serotonin (5-hydroxytryptamine; 5-HT) neurotransmission in key neural circuits may contribute to these interlocked phenotypes well as the altered neurobiological states evoked by cocaine that precipitate relapse events. As such, 5-HT is an important target in the quest to to understand the neurobiology of relapse-predictive phenotypes, to successfully treat this complex disorder and improve diagnostic and prognostic capabilities. This review emphasizes the role of 5-HT and its receptor proteins in key addiction phenotypes and the implications of current findings to the future of therapeutics in addiction.

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“…These 5-HT 2 receptor subtypes play a prominent role in the modulation of striatal DA function (Abdallah et al, 2009; Navailles and De Deurwaerdere, 2011) and excite striatal ACh and fast spiking GABA interneurons (Blomeley and Bracci, 2005, 2009). The 5-HT 2 receptor antagonists administered within the striatum block DA-mediated oral activity (Plech et al, 1995), synergize D 1 -induced locomotor activity (Bishop and Walker, 2003) and cause retrograde amnesia in rats (Prado-Alcala et al, 2003a,b). Loss of 5-HT 2C receptors enhances behavioral sensitivity to D 1 receptor activation (Abdallah et al, 2009).…”

Section: Performance In the 5-csrt Taskmentioning

confidence: 99%

Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task

Carli

Invernizzi

2014

Front. Neural Circuits

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Executive functions are an emerging propriety of neuronal processing in circuits encompassing frontal cortex and other cortical and subcortical brain regions such as basal ganglia and thalamus. Glutamate serves as the major neurotrasmitter in these circuits where glutamate receptors of NMDA type play key role. Serotonin and dopamine afferents are in position to modulate intrinsic glutamate neurotransmission along these circuits and in turn to optimize circuit performance for specific aspects of executive control over behavior. In this review, we focus on the 5-choice serial reaction time task which is able to provide various measures of attention and executive control over performance in rodents and the ability of prefrontocortical and striatal serotonin 5-HT1A, 5-HT2A, and 5-HT2C as well as dopamine D1- and D2-like receptors to modulate different aspects of executive and attention disturbances induced by NMDA receptor hypofunction in the prefrontal cortex. These behavioral studies are integrated with findings from microdialysis studies. These studies illustrate the control of attention selectivity by serotonin 5-HT1A, 5-HT2A, 5-HT2C, and dopamine D1- but not D2-like receptors and a distinct contribution of these cortical and striatal serotonin and dopamine receptors to the control of different aspects of executive control over performance such as impulsivity and compulsivity. An association between NMDA antagonist-induced increase in glutamate release in the prefrontal cortex and attention is suggested. Collectively, this review highlights the functional interaction of serotonin and dopamine with NMDA dependent glutamate neurotransmission in the cortico-striatal circuitry for specific cognitive demands and may shed some light on how dysregulation of neuronal processing in these circuits may be implicated in specific neuropsychiatric disorders.

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Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats

Cited by 24 publications

References 31 publications

The four-plates test–retest paradigm to discriminate anxiolytic effects

The four-plates test–retest paradigm to discriminate anxiolytic effects

Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction

Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task

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