2015
DOI: 10.1016/j.jad.2015.06.003
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Enhanced inflammatory and T-helper-1 type responses but suppressed lymphocyte proliferation in patients with seasonal affective disorder and treated by light therapy

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Cited by 28 publications
(22 citation statements)
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“…Finally, a recent paper focused on a possible relationship between the immune system and SAD. Song et al46 found that SAD patients have enhanced inflammatory responses in winter in their depressed state compared to healthy controls. Light therapy improved mood and normalized their immune function.…”
Section: Working Mechanism and Etiologymentioning
confidence: 99%
“…Finally, a recent paper focused on a possible relationship between the immune system and SAD. Song et al46 found that SAD patients have enhanced inflammatory responses in winter in their depressed state compared to healthy controls. Light therapy improved mood and normalized their immune function.…”
Section: Working Mechanism and Etiologymentioning
confidence: 99%
“…Such photic treatments have previously been used for the treatments of sleep disorders, in which exposure to bright light has been found to reset the phase of misaligned circadian rhythms when administered shortly before awakening or shortly before sleeping. 94 In a study by Song et al, 95 patients with seasonal affective disorder (SAD), a condition primary associated with photoperiod-induced circadian phase shifts in important immunomodulatory mediators, had significantly enhanced Th1-type inflammatory responses in winter months. Bright light therapy during the course of 4 wk was found to normalize the inflammatory response in these patients with SAD by decreasing the production of proinflammatory cytokines IL-1β, TNF-α, and IFN-γ; suppressing macrophage activity; increasing the release of anti-inflammatory cytokine IL-10 in mitogen-stimulated blood; and reversing the reduced lymphocyte proliferation and IL-2 production found in these patients.…”
Section: Circadian Clock Integrates Environmental and Metabolic Cuesmentioning
confidence: 99%
“…Bright light therapy during the course of 4 wk was found to normalize the inflammatory response in these patients with SAD by decreasing the production of proinflammatory cytokines IL-1β, TNF-α, and IFN-γ; suppressing macrophage activity; increasing the release of anti-inflammatory cytokine IL-10 in mitogen-stimulated blood; and reversing the reduced lymphocyte proliferation and IL-2 production found in these patients. 95 …”
Section: Circadian Clock Integrates Environmental and Metabolic Cuesmentioning
confidence: 99%
“…However, even if subsequent light therapy improved depressive symptoms in SAD patients, IL-6 concentrations were not significantly altered [54]. Another study used separation of lymphocytes and monocytes/macrophages in the whole blood, unstimulated and stimulated with mitogens, and demonstrated an overall immune activation in SAD patients in the winter, partially normalized after light therapy [55]. Specifically, macrophage activity (e.g.…”
Section: Introductionmentioning
confidence: 99%