Enhanced induction of apoptosis of human gastric carcinoma cells after preoperative treatment with 5-fluorouracil

Abstract

The authors demonstrated enhanced apoptosis in gastric tumors after continuous intravenous infusion of 5-FU for 7 days. This result suggests that it may be possible to evaluate the effects of chemotherapy by detecting apoptotic cells.

Chemosensitivity of peritoneal micrometastases as evaluated using a green fluorescence protein (GFP)‐tagged human gastric cancer cell line

“…However, there are several possible explanations: 1) 5-FU is known to induce apoptosis in gastric cancer xenografts in a concentration-dependent manner. 33,34) The anti-cancer drug can reportedly penetrate tumor tissue only 100-250 µm from the surface, which might be sufficient, at least in part, for the treatment of omental micrometastases with a diameter of less than 0.5 mm, but not for more advanced metastasis of larger size. 35) Therefore, preferential inhibition of peritoneal metastasis may be due to higher apoptosis induced by a higher concentration of 5-FU in the micrometastatic foci.…”

Expression of Fas and Fas ligand in human gastric adenomas and intestinal-type carcinomas: correlation with proliferation and apoptosis

“…The findings are summarized as follows: (i) a higher apoptotic index (AI; percentage of apoptotic tumor cells) in tubular adenomas, followed by welldifferentiated (intestinal-type), and poorly differentiated (diffuse-type) carcinomas [1][2][3], (ii) lower AI in carcinomas expressing P53 oncoprotein [3,4], (iii) increase in AI with preoperative chemotherapy [5], (iv) association of thymidine phosphorylase expression with lower AI [6], and (v) an inverse correlation between AI and intratumoral microvessel density (IMVD) [6]. Thus, apoptosis is correlated with tumor histology, p53 gene status, and cytotoxic agents such as anticancer agents, as well as being correlated with blood supply.…”

Therapeutic mechanism of ginkgo biloba exocarp polysaccharides on gastric cancer

“…Recent studies showed apoptosis played a main role in the prevention and treatment of tumors [11][12][13] . Anti-tumor effect of many chemotherapy drugs could induce apoptosis in tumor cells [14,15] . Cell apoptosis was regulated by genes [16,17] .…”