Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes

Shen, Lina; Zhang, Yongtai; Wang, Qin; Xu, Ling; Feng, Nianping

doi:10.1016/j.ijpharm.2013.11.017

Cited by 189 publications

(96 citation statements)

References 24 publications

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“…The final concentration of PF in each formulation was 0.2% (w/v), and a uniform design was used in this study to optimize the glycerosome formulations. 17 STO-glycerosomes were prepared based on optimized formulations. First, the PF-loaded hydration solution was prepared, and then 2% (v/v) STO was added to the milky solution, and whirled for 20 min, followed by a probe sonication.…”

Section: Preparation Of Glycerosomes and The Compared Preparationsmentioning

confidence: 99%

“…14 Ethosomes are a novel type of liposomes containing a high concentration of shortchain alcohols, including ethanol, propylene glycol, or even a mixture of ethanol and propylene glycol. [15][16][17] The addition of ethanol improves the deformability of vesicles, thus overcoming some of the disadvantages of the conventional liposomes, but also carries the risk of skin irritation.…”

Section: Introductionmentioning

confidence: 99%

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Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions.

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Section: Preparation Of Glycerosomes and The Compared Preparationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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“…Shen et al (2014) was 87, 51 and 4.5 times higher than from liposomes, phosphate buffer and hydroethanolic solution, respectively (p50.01). The quantity of THP remaining in the skin at the end of the 18 h experiment was statistically significantly greater from the ethosomal system than from liposomes or a control hydroethanolic solution.…”

Section: Touitou Et Al (2002b)mentioning

confidence: 90%

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Pandey¹,

Golhani²,

Shukla³

2014

Drug Delivery

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Delivery across skin is attractive due to its easy accessibility. However, drug delivery across skin is still a challenge in biomedical sciences. Over the past few decades, various successful novel devices and techniques have emerged to optimize drug delivery across skin whose obstructing behavior constricts entry of most of the therapeutic agents. Inability of various conventional vesicular formulations, e.g. liposomes to pass through the tapered (430 nm) intercellular channels of stratum corneum, rendered invention of some lipid based vesicular carrier systems such as ethosomes which consist of phospholipid, ethanol and water. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. In spite of their sophistication in conceptuality, they are exemplified by easiness in their preparation, safety and efficacy -a combination that can highly inflate their application. This review attempts to describe all aspects of ethosomes including roles and upshots of different excipients, various methods of preparation and characterizations, research reports on various drug deliveries, patent reports and future prospects.

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“…An overview of further plant based polyphenols with their health benefits and restrictions is given in Table 2. Poor water solubility and unsatisfactory cutaneous permeability 44 Low absorption (1.2%) 45 Parsley and onion 44 …”

Section: Introductionmentioning

confidence: 99%

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods

Sadeghpour¹

2016

JNHFE

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The especial features and advanced characteristics of Lyotropic Liquid Crystalline (LLC) phases as potent nano materials for encapsulation and the development of novel delivery systems for nutraceuticals and other bioactive compounds are reviewed. Exemplary, a focus is set on the health benefits of flavonoids and their current restrictions in bioavailability. Accordingly, our visions for application of LLC phases in the engineering of enhanced flavonoid-based food supplements and correlated challenges to overcome are highlighted.

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Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes

Cited by 189 publications

References 24 publications

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods

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