Enhanced heat stability and storage modulus in novel PTMO-intercalated clay platelets/PTMO-based polyurethane nanocomposites

Behniafar, Hossein; Ahmadi-khaneghah, Aziz; Haghighi‐Yazdi, Mojtaba

doi:10.1007/s10965-016-1097-z

Cited by 13 publications

(6 citation statements)

References 33 publications

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“…According to the results obtained through the procedure carried out, it was possible to achieve full exfoliation of the clay platelets. Furthermore, the obtained nanocomposites polymers presented better storage moduli compared to polymer matrices in the absence of nanofillers [49]. However, it is also possible to achieve both structures in the same material.…”

Section: Synthesis Methodsmentioning

confidence: 88%

Smart Polymer Nanocomposites: Recent Advances and Perspectives

Vera¹,

Mella²,

Urbano³

2020

J. Chil. Chem. Soc.

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Nanocomposite polymers have received considerable interest in research for the last three decades. Those nanocomposite polymers that are sensitive to a stimulus such as pH, temperature, magnetism, and electricity, among others, called smart or intelligent nanocomposite polymers had received even greater attention due to their potential technological applications. Applications of these polymers include flexible electronic devices, sensors, self-healing polymers, shape-memory materials, etc. The sensitivity of the material can come from both the polymer that acts as a matrix and the nanofiller, resulting in a material that combines properties of each of its components and that each one will not have separately. This mini-review aims to provide an update on the most recent and significant applications in the area of stimuli-responsive polymer nanocomposites, emphasizing the most innovative applications in biomedicine and catalysis developed in the last three years.

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Section: Synthesis Methodsmentioning

confidence: 88%

Smart Polymer Nanocomposites: Recent Advances and Perspectives

Vera¹,

Mella²,

Urbano³

2020

J. Chil. Chem. Soc.

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“…We first optimized the process parameters of the chlorination reaction, including chlorination reagents, chlorination reagent amount, and temperature (Table 1). Some common chlorination reagents were evaluated, including oxaloyl chloride ((COCl) 2 ), phosphorus oxychloride (POCl 3 ), and thionyl chloride (SOCl 2 ), but both monochloro- (11) and dichloroproducts (11′) with different yields were obtained in all reactions. By contrast, 2.0 equivalent of phosphorus oxychloride showed a higher conversion than the other chlorinating reagents at reflux (entry 5), affording 11 in 35% and 11′ in 28%, respectively.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…9 Meanwhile, because of hydrazine's high carcinogenicity/toxicity, energy content and wide flammability range, 10 we needed to detect the concentration of hydrazine vapor to prevent explosion in the scale-up experiment. According to the calculation of the level of hydrazine in the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) M7 guideline, 11 the maximum allowed level of hydrazine was 39 μg/day in oral drugs. The recommended daily dosage of olaparib tablet was 600 mg.…”

Section: ■ Introductionmentioning

confidence: 91%

“…Although the yield was close to that of medicinal chemistry route, using industrial byproduct phthalhydrazide (10) as the starting material effectively reduced the production cost and solved the phthalhydrazide landfill pollution to the environment. In the chlorination of phthalhydrazide, excess dichloro-product (11′) was directly converted into chlorophthalazinone (11) by acid hydrolysis during the workup process, affording 11 in 92% yield. The addition of LiCl improved the conversion of the organozinc reagent and suppressed the side reaction, as well as allowed to perform the subsequent Negishi coupling reaction in one-pot.…”

Section: ■ Conclusionmentioning

confidence: 99%

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Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib

et al. 2022

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Olaparib (Lynparza) is a potent, highly selective inhibitor of poly(ADP-ribose)polymerase enzymes, approved by the U.S. FDA and EMA for the treatment of ovarian cancer. Herein, we report a practical, economical, and scalable process for the synthesis of 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, a key intermediate for olaparib. The lowcost industrial byproduct phthalhydrazide was used as the starting material to construct the phthalazinone moiety, which allowed access to the key intermediate by the Negishi coupling reaction. Optimization of each step has enabled the development of an environmentally benign and robust process with effective control of impurities.

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“…The cationic modification of montmorillonite is affected by the length of the organic cationic chain, the type of functional group, and the number of cations [79,114,115]. Cationic organic long carbon chain modifiers are more advantageous.…”

Section: Cation Exchange Modificationmentioning

confidence: 99%

Progress in Montmorillonite Functionalized Artificial Bone Scaffolds: Intercalation and Interlocking, Nanoenhancement, and Controlled Drug Release

Dong-ying

Пин

et al. 2022

Journal of Nanomaterials

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Montmorillonite (MMT) has attracted widespread attention in the field of bone tissue engineering in recent years because of its interlayer domain structure. The progress of MMT application was reviewed in this article. Concretely, the application of MMT was mainly explained from the structural characteristics, mechanical strengthening mechanism, organic functionalization, and drug loading and release. Firstly, the polar polymer molecular chains are easily induced into the interlayer domain of MMT to form an interlock and achieve the mechanical strengthening of scaffold. Secondly, the “sandwich” sheet structure of MMT can be exfoliated into graphene-like MMT nanosheets, providing a nanostrengthening effect for polymer matrix. In addition, MMT’s interlayer domain provides a favorable environment for the loading and slow release of drugs, and it is an ideal platform for the functionalization of bone scaffolds. More importantly, MMT can be easily modified by cation exchange and chemical reaction to further improve the compatibility of composites: such as strengthening mechanical interlocking and nanostrengthening effects and achieving controllable loading and release of drugs. It is expected to provide a reference for improving the application of bone tissue engineering scaffolds.

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Enhanced heat stability and storage modulus in novel PTMO-intercalated clay platelets/PTMO-based polyurethane nanocomposites

Cited by 13 publications

References 33 publications

Smart Polymer Nanocomposites: Recent Advances and Perspectives

Smart Polymer Nanocomposites: Recent Advances and Perspectives

Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib

Progress in Montmorillonite Functionalized Artificial Bone Scaffolds: Intercalation and Interlocking, Nanoenhancement, and Controlled Drug Release

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