Enhanced Gene Transfer to Pancreatic Islets Using Glucagon-Like Peptide-1

Lee, Byung Wan; Kim, M.-H.; Chae, Hee Young; Hwang, Hyo-Jeong; Kang, Dong‐Chul; Ihm, Sung Hee

doi:10.1016/j.transproceed.2012.10.040

Cited by 4 publications

(1 citation statement)

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“…When the intestinal mechanical barrier is damaged, endotoxins enter the blood circulation, causing endotoxemia. Then, the intestinal bacteria can migrate into the intestinal lymph nodes, blood, liver or spleen, causing bacterial translocation [23][24][25][26][27][28][29]. Therefore, how to protect the intestinal barrier function as well as to reduce the intestinal permeability and subsequently to decrease bacterial translocation in OJ is the key to the effective reduction of morbidity and mortality of OJ.…”

Section: Discussionmentioning

confidence: 99%

Expression of TLR2 and TLR5 in distal ileum of mice with obstructive jaundice and their role in intestinal mucosal injury

Tian

Zhang

2019

Arch Med Sci

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Introduction: The aim was to investigate the expression of TLR2 and TLR5 in the distal ileum of mice with obstructive jaundice (OJ) and their role in intestinal mucosal injury. Material and methods: A total of 100 male C57BL/6J mice were randomly assigned to two groups: (I) sham operation (SH); (II) bile duct ligation (BDL). The mice were respectively sacrificed before operation and on the 1 st , 3 rd , 5 th and 7 th days after operation to collect specimens. Various indicators were detected by PCR, immunohistochemistry and other methods. Results: TLR2 was increased gradually with the extension of OJ time in the BDL group (p < 0.05). However, the changes in the expression of TLR5 were not obvious at different time points. The amount of Bifidobacteria and Lactobacillus showed downward trends in intestinal tract of the BDL group. Furthermore, the amount of Escherichia coli was increased in intestinal tract of the BDL group. The pathological score of intestinal mucosa and the expression of NF-κB increased gradually in the BDL group with the extension of OJ time. There were positive correlations between the pathological score of intestinal mucosa and expressions of TLR2(r = 0.767, p < 0.05) and NF-κB (r = 0.817, p < 0.05) in BDL group. NF-κB expression was positively correlated with TLR2 expression(r = 0.706, p < 0.05). Conclusions: Disturbance of intestinal flora caused by OJ could increase the expression of NF-κB via up-regulating the expression of TLR2 to activate the downstream signaling pathway, thus aggravated the injury of intestinal mucosa.

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Section: Discussionmentioning

confidence: 99%

Expression of TLR2 and TLR5 in distal ileum of mice with obstructive jaundice and their role in intestinal mucosal injury

Tian

Zhang

2019

Arch Med Sci

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Gene delivery to pancreatic islets for effective transplantation in diabetic animal

Lee

Kim

et al. 2017

Journal of Industrial and Engineering Chemistry

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The Making of Pancreatic β Cells: Advances and Apprehensions

Radha¹,

Muniraj

Rasu³

2016

IJPPE

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Abstract. Diabetes is a dreadful disease, which in its acute stages, causes severe multiple organ failure. It is also one of the world's oldest diseases. Type 1 Diabetes is characterized by the absence of insulin and exogenous insulin dependency. Stem cell therapy is one of the promises of this era, as there are numerous studies on Rodents, Frogs, Zebra fish, Dog and Chick, elucidating the wide array of genes, transcription factors, signaling pathways and compounds, which could promote β cell neogenesis, regeneration, differentiation and trans-differentiation. Even though, a recent PubMed search on the keyword 'Pancreatic beta cell proliferation' revealed around 3000 reports, this review focuses on the trends attempted in recent years and infers certain critical aspects in the observations.

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Enhanced Gene Transfer to Pancreatic Islets Using Glucagon-Like Peptide-1

Cited by 4 publications

References 43 publications

Expression of TLR2 and TLR5 in distal ileum of mice with obstructive jaundice and their role in intestinal mucosal injury

Expression of TLR2 and TLR5 in distal ileum of mice with obstructive jaundice and their role in intestinal mucosal injury

Gene delivery to pancreatic islets for effective transplantation in diabetic animal

The Making of Pancreatic β Cells: Advances and Apprehensions

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