Enhanced gastric tolerability and improved anti-obesity effect of capsaicinoids-loaded PCL microparticles

Almeida, Martinha Antunes; Nadal, Jéssica Mendes; Grassiolli, Sabrina; Paludo, Kátia Sabrina; Zawadzki, Sônia Faria; Cruz, Letícia; Paula, Josiane Padilha de; Farago, Paulo Vítor

doi:10.1016/j.msec.2014.03.049

Cited by 30 publications

(25 citation statements)

References 30 publications

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“…Liposomal encapsulation also strongly improved the solubility and oral bioavailability of capsaicin . The enhanced gastric tolerability and better anti‐obesity effect of capsaicinoid (mainly capsaicin‐loaded) microparticles had been noted previously …”

Section: Introductionmentioning

confidence: 67%

Fabrication of capsaicin emulsions: improving the stability of the system and relieving the irritation to the gastrointestinal tract of rats

et al. 2019

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BACKGROUND: Capsaicin, as a major pungent ingredient of peppers, has many health benefits. However, the strong irritation effect of capsaicin inhibits its application in the food industry. Emulsions can be an effective approach to alleviate the irritation. RESULTS:In this study, we used tocopheryl polyethylene glycol 1000 succinate (TPGS) as an emulsifier to prepare capsaicin emulsions through high-pressure homogenization. Capsaicin emulsions with a particle size of about 100 nm, −36.4 mV zeta potential, and 91.9% encapsulation efficiency were prepared successfully and showed better environmental stability and higher antioxidant activity. Emulsions reduced the cumulative release of capsaicin and had no toxic effect on buffalo rat liver (BRL-3A) cells. Moreover, the gastrointestinal injury model of rats showed that emulsions reduced the strong irritation of capsaicin. CONCLUSION: This work provides a theoretical basis for the application of irritant ingredients in food industry. Statistical analysisAll experiments were performed at least three times and were reported as the mean ± standard deviation (SD). The data were analyzed by one-way ANOVA using the SPSS 20.0 package (IBM, Armonk, NY, USA) followed by Duncan's multiple-range test to determine significant differences. Means were considered to be statistically distinct at P < 0.05.J Sci Food Agric 2020; 100: 129-138 Figure 4. H&E staining of gastrointestinal tissues (× 200) (A and B), the effect of different treatments on the mRNA levels of tight junction proteins in gastrointestinal tissues of SD rats and the levels of LPS in plasma of SD rats. (C) ZO-1, (D) occludin, (E) claudin-1, (F) LPS in plasma. Data presented as mean ± SEM, n ≥ 5, * P < 0.05, ** P < 0.01. J Sci Food Agric 2020; 100: 129-138 CONCLUSIONSThis work prepared safe and stable emulsions by high-pressure homogenization using an FDA-approved material, TPGS, as an J Sci Food Agric 2020; 100: 129-138

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Section: Introductionmentioning

confidence: 67%

Fabrication of capsaicin emulsions: improving the stability of the system and relieving the irritation to the gastrointestinal tract of rats

et al. 2019

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“…The simple emulsion/solvent evaporation method was performed to obtain capsaicinoids-loaded PCL microparticles as described in reference[ 16 ]. In the present work, we used the formulations containing 3 and 5% (w/w) of capsaicinoids (capsaicin and dihydrocapsaicin), named MC3 and MC5, respectively.…”

Section: Experimental Procedures and Resultsmentioning

confidence: 99%

“…The particle size was measured by laser diffraction spectrometry in a Cilas 920 L-apparatus. The details of SEM and particle size determination can also be found in reference[ 16 ]. We show in Fig 3 the spherical morphology of MC3 (2a) and MC5 (2b) samples without porous presence on the surface.…”

Section: Experimental Procedures and Resultsmentioning

confidence: 99%

“…In this study, we propose and analyze some aspects of a phenomenological model to drug release. A particular case of this model is applied to the analysis of experimental data of capsaicinoids–loaded PCL microparticles[ 16 ], where a complete understanding on the drug release mechanism is still lacking. Despite the pharmacological properties of capsaicinoids, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles

et al. 2016

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We present a generalmodel based on fractional diffusion equation coupled with a kinetic equation through the boundary condition. It covers several scenarios that may be characterized by usual or anomalous diffusion or present relaxation processes on the surface with non-Debye characteristics. A particular case of this model is used to investigate the experimental data obtained from the drug release of the capsaicinoids-loaded Poly (ε-caprolactone) microparticles. These considerations lead us to a good agreement with experimental data and to the conjecture that the burst effect, i.e., an initial large bolus of drug is released before the release rate reaches a stable profile, may be related to an anomalous diffusion manifested by the system.

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“…That is, to collect the fruits at an optimal time point, it was necessary to consider the time between planting, flowering, and fruiting, rather than simply observing visible changes. Long-time consumption of capsaicin promotes fat reduction in humans (Arent et al, 2018;Leung, 2014) and the induction of skeletal muscle hypertrophy (Ito et al, 2013), and potentially reduces obesity (Almeida et al, 2014;Mun et al, 2014). These effects may be caused by capsaicin, a vanilloid belonging to the vanillyl group.…”

Section: No Quantification Using a Modified Griess Methodsmentioning

confidence: 99%

Capsicum Cultivated Under Adverse Conditions Produces High Concentrations of Antioxidants and Capsaicinoids

Kajiya¹,

Yamanouchi²,

Tanaka³

et al. 2020

JAS

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Growing crops in sabulous soil is challenging owing to limited oligotrophy and low water retention. Nonetheless, some plants adapt well, imparting favorable properties to the fruit. This study investigated the influence of sandy soil (southern Japan) on red pepper by assessing the levels of pungent components, antioxidant activity, and vascular endothelial function. Leaves and fruits of Habanero orange and Tabasco pepper, the two varieties most suitable for cultivation in sandy soil, were analyzed for size, color, and pungent component composition. Pungent components were detected in the seeds and placenta of fruits but not in leaves or flowers. Antioxidant activity and nitric oxide production in human vascular endothelial cells were evaluated to detect differences in functionality. Capsicum peppers cultivated in sandy soil exhibited higher levels of antioxidants than peppers cultivated under nutrient-rich conditions (control) and induced nitric oxide levels in vascular endothelial cells similar to control peppers. Especially Satsuma-Habanero orange peppers cultivated in sandy soil exhibited the highest antioxidant activity. The fruits from pepper plants cultivated in sabulous soil could be harvested for a significantly longer period and were slower to spoil than control peppers; therefore, Satsuma-Capsicum plants may be commercially viable in oligotrophic areas.

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Enhanced gastric tolerability and improved anti-obesity effect of capsaicinoids-loaded PCL microparticles

Cited by 30 publications

References 30 publications

Fabrication of capsaicin emulsions: improving the stability of the system and relieving the irritation to the gastrointestinal tract of rats

Fabrication of capsaicin emulsions: improving the stability of the system and relieving the irritation to the gastrointestinal tract of rats

Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles

Capsicum Cultivated Under Adverse Conditions Produces High Concentrations of Antioxidants and Capsaicinoids

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