Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles

Lenzi, E. K.; Novatski, Andressa; Farago, Paulo Vítor; Almeida, Martinha Antunes; Zawadzki, Sônia Faria; Neto, R. Menechini

doi:10.1371/journal.pone.0157662

Cited by 4 publications

(3 citation statements)

References 34 publications

(42 reference statements)

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“…The drug delivery systems with a controlled and targeted release represent an alternative administration of a chili pepper extract. Lenzi et al 15 studied the diffusion process and the release of CAPs from poly(ε-caprolactone) microparticles; they obtained spherical particles that can deliver the CAPs rapidly to initiate the therapeutic effect, and the experimental release and diffusion profile were very similar to others estimated by Fick's law. Hydroxypropyl-beta-cyclodextrin, carboxymethyl-chitosansodium hydrogels, polyethylene glycol-polylactic-coglycolic acid thermosensitive hydrogel, flexible membrane vesicles, niosomal carriers, liposomes, and nanofibers were also developed as CAP carriers.…”

Section: Introductionmentioning

confidence: 65%

Synthesis and characterization of a polyurethane carrier used for a prolonged transmembrane transfer of a chili pepper extract

Borcan

Dudás

Len

et al. 2018

IJN

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PurposeRed chili peppers have been highly valued in gastronomy and traditional medicine since ancient times; it seems that it is not just an ingredient for food but also a good remedy for various medical conditions such as increased blood pressure and high levels of serum triglycerides and cholesterol, myocardial infarction, arthritis, and migraines. The objective of this study is the characterization of a new carrier used for encapsulated extract.MethodsChili pepper extract was obtained and was physically entrapped inside polyurethane microparticles in order to diminish the irritative potential of this extract. The particles were evaluated by Zetasizer measurements, small-angle neutron scattering and thermal analysis, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy; the encapsulation efficacy and the drug release profile were assessed by UV-Vis spectroscopy. Bioevaluations on mice skin were performed to predict the irritative potential of the samples.ResultsTwo different types of samples were compared: hollow polyurethane microparticles vs polyurethane particles containing the natural extract. The sizes of the particles were very similar, but the sample containing the extract presents three particle populations (the polydispersity index increases from 0.3 to 0.6 from one sample to another). The zeta-potential measurements and SEM images indicate a medium tendency to form clusters, while the UV-Vis study revealed an almost 70% encapsulation efficacy.ConclusionThe results suggest that encapsulation of a chili pepper extract inside polyurethane microparticles leads to a non-irritative product with a prolonged release: ~30% of encapsulated extract is released within the first 8 days and a maximum 45% is reached in 2 weeks.

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Section: Introductionmentioning

confidence: 65%

Synthesis and characterization of a polyurethane carrier used for a prolonged transmembrane transfer of a chili pepper extract

Borcan

Dudás

Len

et al. 2018

IJN

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“…In this formula, the n value reports the type of physical phenomenon associated with the release. For delivery systems with spherical geometry, an n value less than 0.45 indicates that the release is controlled by diffusion (Fickian diffusion); an n value above 0.89 represents the drug release by polymer erosion (case II transport or non-Fickian transport mechanism); and an n value between 0.45 and 0.89 characterizes the anomalous transport with features of both mechanisms [53][54][55]58]. Taking all these into account, the formulation NC-1 showed an n value of 0.8816 by the Korsmeyer-Peppas model, which indicated that the physical mechanism of drug release from the TAC-loaded PCL occurred by the anomalous transport, in which the drug was released by the both Fickian diffusion and relaxation/polyester erosion as aforementioned [53].…”

Section: Model Equation Linear Equation R 2 Adjustedmentioning

confidence: 99%

Characterization and In Vitro and In Vivo Evaluation of Tacrolimus-Loaded Poly(ε-Caprolactone) Nanocapsules for the Management of Atopic Dermatitis

et al. 2021

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Background: Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application of the drug often causes adverse side effects in some patients. Hence, drug nanoencapsulation could be used as an improved novel therapy to mitigate the adverse effects and enhance bioavailability of the drug. Methods: Physicochemical properties, in vitro drug release experiments, and in vivo anti-inflammatory activity studies were performed. Results: TAC-loaded nanocapsules were successfully prepared by the interfacial deposition of preformed polymer using poly(ε-caprolactone) (PCL). The nanoparticulate systems presented a spherical shape with a smooth and regular surface, adequate diameter (226 to 250 nm), polydispersity index below 0.3, and suitable electrical stability (−38 to −42 mV). X-ray diffraction confirmed that the encapsulation method provided mainly the drug molecular dispersion in the nanocapsule oily core. Fourier-transform infrared spectra suggested that nanoencapsulation did not result in chemical bonds between drug and polymer. In vitro drug dissolution experiments showed a controlled release with a slight initial burst. The release kinetics showed zero-order kinetics. As per the Korsmeyer–Peppas model, anomalous transport features were observed. TAC-loaded PCL nanocapsules exhibited excellent anti-inflammatory activity when compared to the free drug. Conclusions: TAC-loaded PCL nanocapsules can be suitably used as a novel nano-based dosage form to control atopic dermatitis.

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“…Also, the fractional pharmacokinetics model has been used to avoid drug accumulation 25 . Moreover, Lenzi et al 26 have presented a distributed order fractional model to investigate the drug release profiles of the capsaicinoids-loaded poly microparticles. In addition to that, Kytariolos et al 27 present a methodology for power-law in vitro or in vivo (disorder media) by employing fractional calculus formalism.…”

Section: Introductionmentioning

confidence: 99%

Anomalous kinetic study of atenolol release from ATN@DNA a core-shell like structure

Hefny

Elmezayyen

Tawfik

2023

Sci Rep

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The need for more efficient drug delivery strategies with ultraprecision and control over the release of drugs has led to the growth of more sophisticated drug-releasing systems as a promising alternative to conventional clinical therapies. This new seed of strategies has explored an encouraging property to overcome the inherent problems of traditional therapies. One of the major challenges for any drug delivery system is the introduction of a complete view of the delivery system. In this article, we intend to elucidate the theoretical proof of concept of the electrosynthesis ATN@DNA core-shell like structure as a model system. Therefore, we present a fractal kinetic model (non-exponential model) taking into consideration the concept of time-dependent diffusion coefficient, which was developed using a numerical method with the help of COMSOL Multiphysics. In addition to that, we present here a general fractional kinetic model in sense of the tempered fractional operator, which leads to better characterized memory properties of the release process. Also, the fractional model is compared with the fractal kinetic model and both offer a good description of drug release processes that present anomalous kinetics. The solutions of the fractal and fractional kinetic models are also fitted successfully with our real-release results.

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Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles

Cited by 4 publications

References 34 publications

Synthesis and characterization of a polyurethane carrier used for a prolonged transmembrane transfer of a chili pepper extract

Synthesis and characterization of a polyurethane carrier used for a prolonged transmembrane transfer of a chili pepper extract

Characterization and In Vitro and In Vivo Evaluation of Tacrolimus-Loaded Poly(ε-Caprolactone) Nanocapsules for the Management of Atopic Dermatitis

Anomalous kinetic study of atenolol release from ATN@DNA a core-shell like structure

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