Enhanced-fluorescent imaging and targeted therapy of liver cancer using highly luminescent carbon dots-conjugated foliate

Wang, Shicai; Chen, Lin; Wang, Junli; Du, Jinglei; Li, Qiang; Gao, Yuduan; Shiratsuchi, Yu; Yang, Yongzhen

doi:10.1016/j.msec.2020.111233

Cited by 41 publications

(15 citation statements)

References 31 publications

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“…In vivo images of tumor-bearing mice after the injection of FA-CDs-DOX displayed strong orange-red fluorescence under Ex at 480 nm light, while no FL signal was observed in tumor-bearing mice treated with CDs or DOX only, indicating their ability to penetrate tumor tissue and skin to achieve FL imaging effects. This FA-CDs-DOX also exhibited significantly higher tumor inhibition in vivo through the targeting ability of FA-CDs-DOX compared to that of free DOX, suggesting the effective improvement of FL image-guided chemotherapeutic effect in liver cancer therapy ( Figure 6(a) ) [ 182 ].…”

Section: Fluorescent Carbon Dots For Bioimaging-guided Therapeutic Ap...mentioning

confidence: 99%

[Retracted] Fluorescent Carbon Dot‐Supported Imaging‐Based Biomedicine: A Comprehensive Review

Phan

Cho

2022

Bioinorganic Chemistry and Applications

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Carbon dots (CDs) provide distinctive advantages of strong fluorescence, good photostability, high water solubility, and outstanding biocompatibility, and thus are widely exploited as potential imaging agents for in vitro and in vivo bioimaging. Imaging is absolutely necessary when discovering the structure and function of cells, detecting biomarkers in diagnosis, tracking the progress of ongoing disease, treating various tumors, and monitoring therapeutic efficacy, making it an important approach in modern biomedicine. Numerous investigations of CDs have been intensively studied for utilization in bioimaging-supported medical sciences. However, there is still no article highlighting the potential importance of CD-based bioimaging to support various biomedical applications. Herein, we summarize the development of CDs as fluorescence (FL) nanoprobes with different FL colors for potential bioimaging-based applications in living cells, tissue, and organisms, including the bioimaging of various cell types and targets, bioimaging-supported sensing of metal ions and biomolecules, and FL imaging-guided tumor therapy. Current CD-based microscopic techniques and their advantages are also highlighted. This review discusses the significance of advanced CD-supported imaging-based in vitro and in vivo investigations, suggests the potential of CD-based imaging for biomedicine, and encourages the effective selection and development of superior probes and platforms for further biomedical applications.

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Section: Fluorescent Carbon Dots For Bioimaging-guided Therapeutic Ap...mentioning

confidence: 99%

[Retracted] Fluorescent Carbon Dot‐Supported Imaging‐Based Biomedicine: A Comprehensive Review

Phan

Cho

2022

Bioinorganic Chemistry and Applications

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“…High cytotoxicity and morphological changes of MCF-7 cancer cells were observed; also, ROS were induced by 15 min 635 nm (25 mW cm −2 ) radiation and achieved higher therapeutic effects [ 187 ]. CDs and nanodiamond have also been studied in cancer treatment utilizing its function of targeted therapy [ 188 – 190 ], PDT [ 191 ], cancer imaging [ 192 ] and antitumor immunity mediation [ 193 , 194 ]. Compared with other carbon materials, research on carbon QDs is in its rising stage.…”

Section: Nanomaterials Used For Cancer Treatmentmentioning

confidence: 99%

Nanomaterials for cancer therapy: current progress and perspectives

et al. 2021

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Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, and electrical properties. Nanomaterials used in cancer therapy can be classified into several main categories. Targeting cancer cells, tumor microenvironment, and immune system, these nanomaterials have been modified for a wide range of cancer therapies to overcome toxicity and lack of specificity, enhance drug capacity as well as bioavailability. Although the number of studies has been increasing, the number of approved nano-drugs has not increased much over the years. To better improve clinical translation, further research is needed for targeted drug delivery by nano-carriers to reduce toxicity, enhance permeability and retention effects, and minimize the shielding effect of protein corona. This review summarizes novel nanomaterials fabricated in research and clinical use, discusses current limitations and obstacles that hinder the translation from research to clinical use, and provides suggestions for more efficient adoption of nanomaterials in cancer therapy.

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“…Transmission electron microscope (TEM) images of PGQD shows a narrow size distribution between 1 and 5 nm with average size diameter of ≈2.75 nm. The high-resolution TEM (HR-TEM) image (Figure 3d) indicates high crystallinity of the PGQD, with a lattice parameter of 0.24 nm, which was the (002) lattice fringes of graphene [32][33][34]. The UV-vis and fluorescence spectra of the PGQD were shown in Figure 4a.…”

Section: Synthesis and Characterizations Of Pgqdmentioning

confidence: 99%

Graphene Quantum Dots prepared by Electron Beam Irradiation for Safe Fluorescence Imaging of Tumor

Cao¹,

Qi²,

Gao³

et al. 2022

Nanotheranostics

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Enhanced-fluorescent imaging and targeted therapy of liver cancer using highly luminescent carbon dots-conjugated foliate

Cited by 41 publications

References 31 publications

[Retracted] Fluorescent Carbon Dot‐Supported Imaging‐Based Biomedicine: A Comprehensive Review

[Retracted] Fluorescent Carbon Dot‐Supported Imaging‐Based Biomedicine: A Comprehensive Review

Nanomaterials for cancer therapy: current progress and perspectives

Graphene Quantum Dots prepared by Electron Beam Irradiation for Safe Fluorescence Imaging of Tumor

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