Graphene Quantum Dots prepared by Electron Beam Irradiation for Safe Fluorescence Imaging of Tumor

Cao, Honghong; Qi, Wei; Gao, Xudong; Wu, Qiang; Tian, Longlong; Wu, Wangsuo

doi:10.7150/ntno.67070

Cited by 17 publications

(8 citation statements)

References 49 publications

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“…The hydrophilicity of GO is suitable for water-soluble PVA and polyethylene glycol (PEG) to form strong hydrogen bonds within the composite, providing mechanical stability to the core-shell fiber. Additionally, the GO and GO derived nanomaterials have the adjustable fluorescence properties that are applicable for bioimaging of tumor and other biomedical therapies with the encapsulation of drug molecules [ 22 , 23 ]. GO toxicity remains controversial, and working concentration is under investigation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

et al. 2022

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Electrospinning is a well-established method for the fabrication of polymer biomaterials, including those with core-shell nanofibers. The variability of structures presents a great range of opportunities in tissue engineering and drug delivery by incorporating biologically active molecules such as drugs, proteins, and growth factors and subsequent control of their release into the target microenvironment to achieve therapeutic effect. The object of study is non-woven core-shell PVA–PEG–SiO2@PVA–GO fiber mats assembled by the technology of coaxial electrospinning. The task of the core-shell fiber development was set to regulate the degradation process under external factors. The dual structure was modified with silica nanoparticles and graphene oxide to ensure the fiber integrity and stability. The influence of the nano additives and crosslinking conditions for the composite was investigated as a function of fiber diameter, hydrolysis, and mechanical properties. Tensile mechanical tests and water degradation tests were used to reveal the fracture and dissolution behavior of the fiber mats and bundles. The obtained fibers were visualized by confocal fluorescence microscopy to confirm the continuous core-shell structure and encapsulation feasibility for biologically active components, selectively in the fiber core and shell. The results provide a firm basis to draw the conclusion that electrospun core-shell fiber mats have tremendous potential for biomedical applications as drug carriers, photocatalysts, and wound dressings.

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Section: Introductionmentioning

confidence: 99%

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

et al. 2022

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“…Overall, this approach was found suitable for tumor imaging with no toxicity issues. [7] In vivo fluorescence imaging provided by Ag 2 Te QDs has limited conditions due to instability and bad brightness. The researchers synthesized Ag 2 Te QDs in high quality at NIR-II under different emissions and modified them with TBP-Te precursor and procured high fluorescence Ag 2 Te core QDs (Figure 1).…”

Section: Qds For Cellular and Tissue Imagingmentioning

confidence: 99%

Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

Singh

Raina

Rishipathak³

et al. 2022

Archiv der Pharmazie

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Quantum dots (QDs) are semiconducting nanoparticles having different optical and electrical properties when compared to larger particles. They exhibit photoluminescence when irradiated with ultraviolet light, which is due to the transition of an excited electron from the valence band to the conductance band followed by the return of the exciting electron back into the valence band. The size and material of QDs can affect their optical and other properties too. The QDs possess special attributes like high brightness, protection from photobleaching, photostability, color tunability, low toxicity, low production cost, a multiplexing limit, and a high surfaceto-volume proportion, which make them a promising tool for biomedical applications. Here, in this study, we summarize the utilization of QDs in different applications including bioimaging, diagnostics, immunostaining, single-cell analysis, drug delivery, and protein detection. Moreover, we discuss the advantages and challenges of using QDs in biomedical applications when compared with other conventional tools.

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“…Although the existing preparation methods of GQDTs [ 25 ] mainly focus on other approaches (i.e., the hydrothermal cutting and the oxidative cutting carbon fiber methods) which are relatively difficult and introduce several strong acids, the radiation synthesis technology appears a more simple, rapid, scaled and efficient preparation method of GQDTs. The electron or ion itself are strong reducing agents, so the extra chemical reductant does not need to be added during the synthesis processes.…”

Section: Introductionmentioning

confidence: 99%

Compositional and Structural Modifications by Ion Beam in Graphene Oxide for Radiation Detection Studies

Cutroneo

Torrisi

Silipigni

et al. 2022

IJMS

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In the present study, graphene oxide foils 10 μm thick have been irradiated in vacuum using same charge state (one charge state) ions, such as protons, helium and oxygen ions, at the same energies (3 MeV) and fluences (from 5 × 1011 ion/cm2 to 5 × 1014 ion/cm2). The structural changes generated by the ion energy deposition and investigated by X-ray diffraction have suggested the generation of new phases, as reduced GO, GO quantum dots and graphitic nanofibers, carbon nanotubes, amorphous carbon and stacked-cup carbon nanofibers. Further analyses, based on Rutherford Backscattering Spectrometry and Elastic Recoil Detection Analysis, have indicated a reduction of GO connected to the atomic number of implanted ions. The morphological changes in the ion irradiated GO foils have been monitored by Transmission Electron, Atomic Force and Scanning Electron microscopies. The present study aims to better structurally, compositionally and morphologically characterize the GO foils irradiated by different ions at the same conditions and at very low ion fluencies to validate the use of GO for radiation detection and propose it as a promising dosimeter. It has been observed that GO quantum dots are produced on the GO foil when it is irradiated by proton, helium and oxygen ions and their number increases with the atomic number of beam gaseous ion.

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Graphene Quantum Dots prepared by Electron Beam Irradiation for Safe Fluorescence Imaging of Tumor

Cited by 17 publications

References 49 publications

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

Compositional and Structural Modifications by Ion Beam in Graphene Oxide for Radiation Detection Studies

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