Enhanced Excretion of Vitamin D Binding Protein in Type 1 Diabetes: A Role in Vitamin D Deficiency?

Thrailkill, Kathryn M.; Jo, Chan‐Hee; Cockrell, Gael; Moreau, Cynthia; Fowlkes, John L.

doi:10.1210/jc.2010-0980

Cited by 118 publications

(117 citation statements)

References 51 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…In our study positive family history for two types of diabetes were 38.73% and changes in HbA1C and 25OHD did not differ in relatives and non-relatives (p-value>0.05). In another study, bidirectional relation between diabetes and vitamin D deficiency was expressed [18], and Borkar showed 86 percent of recent onset diabetic patients were vitamin D deficient [23]. Also, we had vitamin D deficiency in recent onset patients with diabetes.…”

Section: Discussionmentioning

confidence: 72%

See 1 more Smart Citation

Effect of Vitamin D3 Supplement in Glycemic Control of Pediatrics with Type 1 Diabetes Mellitus and Vitamin D Deficiency

Mohammadian

Fatahi

Zaeri

et al. 2015

JCDR

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 72%

“…The Thraikill et al, recognized vitamin D deficiency or insufficiency is slightly more prevalent in diabetic patients with microalbuminuria, especially with the increase in urinary vitamin D Binding protein excretion [18]. Attended children were already checked for microalbuminuria and had no problem.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D3 Supplement in Glycemic Control of Pediatrics with Type 1 Diabetes Mellitus and Vitamin D Deficiency

Mohammadian

Fatahi

Zaeri

et al. 2015

JCDR

View full text Add to dashboard Cite

“…Fourth, because urine albumin excretion was not measured at baseline, we cannot evaluate whether associations of 25(OH)D with change in eGFR are explained by albuminuria. For example, albuminuria could confound the association of low 25(OH)D concentration with GFR loss by causing both urinary losses of vitamin D-binding protein (48) and progressive kidney disease, particularly with diabetes; albuminuria could mediate effects of vitamin D on GFR; or decreased delivery of 25(OH)D to proximal tubular cells could mediate, in part, known associations of albuminuria with GFR loss. Most importantly, our study is observational in nature and subject to residual confounding, given that low 25(OH)D concentration is correlated with a number of metabolic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D and Change in Estimated Glomerular Filtration Rate

Boer¹,

Katz²,

Chonchol³

et al. 2011

Clinical Journal of the American Society of Nephrology

100

View full text Add to dashboard Cite

SummaryBackground and objectives Mounting evidence suggests that 1,25-dihydroxyvitamin D prevents the progression of chronic kidney disease (CKD). It is not clear whether "nutritional" forms of vitamin D affect GFR.Design, setting, participants, & measurements We tested whether serum 25-hydroxyvitamin D concentration (25(OH)D), a measure of total vitamin D intake from cutaneous synthesis and dietary consumption, is associated with loss of estimated GFR among 1705 older adults with predominantly normal baseline kidney function participating in the Cardiovascular Health Study. Baseline 25(OH)D was measured by HPLC-tandem mass spectrometry. GFR was estimated at baseline and 4 years later using the CKD-EPI formula, with rapid GFR loss defined as 12 ml/min per 1.73 m 2 or more over 4 years.Results Rapid GFR loss was observed for 207 participants (12%). Each 10 ng/ml lower 25(OH)D was associated with a 25% greater risk of rapid GFR loss (95% confidence interval [CI] 5%, 49%, P ϭ 0.01), adjusting for potential confounding characteristics. Compared with 25(OH)D Ն30 ng/ml, 25(OH)D concentrations 15 to 29 ng/ml and Ͻ15 ng/ml were associated with 29% (95% CI Ϫ13%, 91%) and 68% (95% CI 1%, 177%) greater adjusted risks of rapid GFR loss, respectively. Magnitudes of association were largest among participants with diabetes. Results were similar evaluating a composite outcome of rapid GFR loss, end stage renal disease, and death.Conclusions Insufficient 25(OH)D may be a modifiable risk factor for early GFR loss. We recommend clinical trials to determine whether vitamin D supplementation prevents the development and progression of CKD.

show abstract

“…This prevents loss of DBP and VitD metabolites by urinary excretion, but can be dysfunctional in chronic disease like diabetes (Thrailkill et al 2011). Megalin and cubilin are both glycoproteins expressed in proximal tubule cells (PTC) and in placenta cells including syncytiotrophoblasts and cytotrophoblasts (Burke et al 2013).…”

Section: Vitamin D Metabolism Transport and Storagementioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

View full text Add to dashboard Cite

Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory diseases. VitD metabolites and the VitD receptor (VDR) influence many tissues including those of the reproductive system. VDR expression has been demonstrated in various cell types of the male reproductive tract, including spermatozoa and germ cells, and in female reproductive tissues including the ovaries, placenta and endometrium. However, the molecular role of VitD signalling and metabolism in reproductive function have not been fully established. Consequently, the aim of this work is to review current metabolic and molecular aspects of the VitD-VDR axis in reproductive medicine and to propose the direction of future research. Specifically, the influence of VitD on sperm motility, calcium handling, capacitation, acrosin reaction and lipid metabolism is examined. In addition, we will also discuss the effect of VitD on sex hormone secretion and receptor expression in primary granulosa cells, along with the impact on cytokine production in trophoblast cells. The review concludes with a discussion of the recent developments in VitD-VDR signalling specifically related to altered cellular bioenergetics, which is an emerging concept in the field of reproductive medicine.Reproduction (2017) 153 R29-R42

show abstract

Enhanced Excretion of Vitamin D Binding Protein in Type 1 Diabetes: A Role in Vitamin D Deficiency?

Abstract: These findings suggest that, theoretically, exaggerated urinary loss of VDBP in T1D, particularly in persons with albuminuria, could contribute mechanistically to vitamin D deficiency in this disease.

Cited by 118 publications

References 51 publications

Effect of Vitamin D3 Supplement in Glycemic Control of Pediatrics with Type 1 Diabetes Mellitus and Vitamin D Deficiency

Effect of Vitamin D3 Supplement in Glycemic Control of Pediatrics with Type 1 Diabetes Mellitus and Vitamin D Deficiency

Serum 25-Hydroxyvitamin D and Change in Estimated Glomerular Filtration Rate

Molecular actions of vitamin D in reproductive cell biology

Contact Info

Product

Resources

About