Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)

Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice

“…We and another group have found that oral administration of capsaicin and its non-pungent analogs capsinoids, both of which are TRPV1 agonists, 1,46) induces anti-obesity effects in both experimental animals and humans. 25,[47][48][49][50][51][52] Because capsaicin and capsinoids not only induce thermogenesis and heat diffusion but also enhance energy expenditure (Kawabata F, Inoue N, Masamoto Y, Matsumura S, Kimura W, Kadowaki M, Higashi T, Tominaga M, Inoue K, and Fushiki T, unpublished results), some TRPA1 and TRPM8 agonists that enhanced thermogenesis in the present study might also increase energy expenditure and have an anti-obesity effect. Recently, Iwasaki et al reported that allyl isothiocyanate and cinnamaldehyde induce aderenaline secretion.…”

Assessment of the Biological Similarity of Three Capsaicin Analogs (Capsinoids) Found in Non-Pungent Chili Pepper (CH-19 Sweet) Fruits

“…6) The strong pungency of hot peppers, but, restricts common long-term usage. Thus, in this context, reports that CH-19 Sweet, a non-pungent cultivar of red pepper, has biological activities similar to those of red pepper despite its non-pungency [7][8][9] are noteworthy. Research with CH-19 Sweet or its extract has also described enhanced energy metabolism and body temperature in studies with humans.…”

“…Research with CH-19 Sweet or its extract has also described enhanced energy metabolism and body temperature in studies with humans. [7][8][9] As illustrated in Fig. 1, CAP consists of a vanillyl moiety and a fatty acid chain that are conjugated with an amide bond.…”

Capsinoids, Non-Pungent Capsaicin Analogs, Reduce Body Fat Accumulation without Weight Rebound unlike Dietary Restriction in Mice

“…11,12) Furthermore, an acute CH-19 Sweet intake in humans has enhanced sympathetic nervous activity, thermogenesis, and energy expenditure as effectively as hot red pepper, 12,13) a chronic CH-19 Sweet intake has reduced the body fat and body weight in healthy people, 14) and a chronic capsinoid intake has enhanced the energy expenditure and fat oxidation in obese people. 15) Since CH-19 Sweet (capsinoids) has little pungency for humans, 9) it is possible that it may be more acceptable for many people than hot red pepper (capsaicin).…”