Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy

Ding, Jianxun; Shi, Fenghua; Li, Di; Chen, Li; Zhuang, Xiuli; Chen, Xuesi

doi:10.1039/c3bm60024f

Cited by 58 publications

(51 citation statements)

References 47 publications

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“…Nanocarriers can be versatile designed to attain passive or active targeting and efficient cellular uptake [4,5]. Components able to recognize stimuli that are unique to certain diseases or pathologies may allow the nanocarrier to release the drug in response to specific pathological triggers [6][7][8]. Unlike pH-sensitive nanocarriers that are intended to release payloads in the mildly acidic extracellular environment of tumors and/ or endo/lysosomal compartments, reduction-sensitive nanocarriers are mostly designed to rapidly dissociate and efficiently release drugs in the cytoplasm and/or cell nucleus [7].…”

Section: Introductionmentioning

confidence: 99%

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Curcio

Blanco-Fernandez

Costoya

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Introductionmentioning

confidence: 99%

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Curcio

Blanco-Fernandez

Costoya

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.In recent years, self-assembled polyester micelles have attracted a great deal of attention in the application for drug delivery, mainly due to its optimal biodegradability and biocompatibility [1,2] . Hydrophilic poly(ethylene glycol) (PEG) and hydrophobic polylactide (PLA) are universally used components in block copolymers, and such copolymers have shown distinctive properties in multiple studies [3,4] .…”

mentioning

confidence: 99%

“…In recent years, self-assembled polyester micelles have attracted a great deal of attention in the application for drug delivery, mainly due to its optimal biodegradability and biocompatibility [1,2] . Hydrophilic poly(ethylene glycol) (PEG) and hydrophobic polylactide (PLA) are universally used components in block copolymers, and such copolymers have shown distinctive properties in multiple studies [3,4] .…”

mentioning

confidence: 99%

Poly(β-cyclodextrin)-mediated polylactide-cholesterol stereocomplex micelles for controlled drug delivery

et al. 2017

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A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin) (PCD) with the molar ratios of CHOL/β-CD at 1 : 0.5, 1 : 1, and 1 : 2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.In recent years, self-assembled polyester micelles have attracted a great deal of attention in the application for drug delivery, mainly due to its optimal biodegradability and biocompatibility [1,2] . Hydrophilic poly(ethylene glycol) (PEG) and hydrophobic polylactide (PLA) are universally used components in block copolymers, and such copolymers have shown distinctive properties in multiple studies [3,4] . Poly(L-lactide) (PLLA) and poly(Dlactide) (PDLA) are two stereoisomeric structures of PLA. In more recent studies, PEG-PLLA and PEG-PDLA copolymers were blended into stereocomplex systems of PEG-PLLA/PDLA [5,6] . It was reported that compared with isotactic polymers, the constructed stereocomplex micelles showed enhanced kinetic stability [7] , higher drug loading efficiency [8] , and more sustained drug release [9] .Cyclodextrins (CDs) are a kind of macrocyclic oligosaccharides consisting of six to eight α-Dglucopyranoside units in a ring linked by α-1,4-glycosidic bond. CDs feature distinctive construction where all polar groups are located at the surface, forming a relatively nonpolar cavity to combine various lipophilic guest molecules [10,11] , including adamantane (ADA), cholesterol (CHOL), and aromatic compounds, etc. Therefore, CDs hold enormous potential in forming host-guest inclusion systems for drug delivery. As a member of CDs whose application has been approved by the US Food and Drug Administration (FDA), β-CD is made up of seven glucopyranoside monomers and has gained wide attention due to its inclusion formation capability, along

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“…Reduction-responsive polymeric nanogels for tumor-specific targeting have shown potential for targeted intra-cellular delivery of chemotherapeutic drugs in cancer therapy [48][49][50][51][52][53][54]. Thermo-responsive and pH-responsive polypeptide vesicles revealed a promising approach for smart drug delivery with enhanced efficacy and security [54][55][56][57] demonstrating a prospective future of nanoparticle drug delivery in the disease management.…”

Section: Future Trendsmentioning

confidence: 99%

Nanoparticles for Improved Delivery of Poorly Soluble Drugs

N¹

2016

J. Drug

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Nanoparticle based drug products are of growing interest in the field of pharmaceutics. Enhancing saturation solubility and dissolution velocity by preparing drug nanoparticles correlates with faster absorption rates. The faster absorption rates can correlate into better bioavailability, reduction in fed and fast effects and inter-subject variability with improved therapeutic response. Drug nanoparticles have shown potential applications in developing several oral and parenteral dosage forms with improved therapeutics. Suitable formulations for the commonly used routes of administration can be identified employing nanoparticle technology. Drug nanoparticles provide the discovery scientist an alternate avenue for screening and identifying a superior drug delivery system. For toxicologist, the approach provides a means for dose escalation with minimum amount of drug substance. In the recent years, formulating poorly water-soluble compounds using a nanoparticulate approach has evolved from a conception to a realization whose versatility and applicability are being vastly recognized. In the present review, industrially relevant production technologies are critically reviewed. The nanoparticle characterization techniques and potential challenges involved in the development of drug nanoparticles were discussed in detail.

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Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy

Abstract: The combination of acid-sensitive doxorubicin derivatives with a pH and reduction dual-responsive nanogel exhibited improved chemotherapy security and efficacy.

Cited by 58 publications

References 47 publications

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Poly(β-cyclodextrin)-mediated polylactide-cholesterol stereocomplex micelles for controlled drug delivery

Nanoparticles for Improved Delivery of Poorly Soluble Drugs

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