Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Curcio, Manuela; Blanco-Fernandez, Bárbara; Costoya, Alejandro; Concheiro, Angel; Puoci, Francesco; Álvarez-Lorenzo, Carmen

doi:10.1016/j.ejpb.2015.04.010

Cited by 14 publications

(5 citation statements)

References 66 publications

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“…Due to the property of cleavage, disulfide bonds are widely used in the fabrication of redox‐responsive nanoparticles (NPs) 13,14 . The disulfide bonds‐based NPs usually used as the vehicles for the delivery of antitumor drugs 15,16 . Usually, the tumor tissues have special microenvironments, for example, low pH values, 17 high GSH concentrations, 18 and high temperatures 19 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of glutathione‐responsive nanoparticles from the disulfide bond‐bridged block copolymer

Shi

Yang

Pan

et al. 2021

Polymers for Advanced Techs

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The purpose of this paper is to fabricate novel nanoparticles (NPs) from a single disulfide bond‐bridged block copolymer poly(hydroxyethyl methacrylate)‐S‐S‐polycaprolactone (PHEMA‐S‐S‐PCL). The novel biomaterial was synthesized by ring‐opening polymerization and reversible addition–fragmentation chain transfer polymerization. The cargo‐free NPs were fabricated with the solvent evaporation method, and studies on NPs' characterizations were carried out. The hydrogen nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy spectra confirmed the synthesis of PHEMA‐S‐S‐PCL copolymer. Thermo‐gravimetric analysis curves indicated that the obtained PHEMA‐S‐S‐PCL copolymer had good thermostability. Transmission electron microscopy and dynamic light scatter results suggested that the cargo‐free NPs were in round shapes with an average diameter of 103.6 ± 0.12 nm. The low critical micelle concentration of cargo‐free NPs (7.9 × 10−4 mg/ml) indicated that these NPs would keep their spherical shapes after being attenuated by abundant liquid (e.g., blood or body fluid). Furthermore, these NPs showed high stability at the presence of bovine serum albumin. Therefore, it could be speculated that these NPs would not be absorbed by proteins in blood, and they could be used as a candidate carrier for drug delivery.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of glutathione‐responsive nanoparticles from the disulfide bond‐bridged block copolymer

Shi

Yang

Pan

et al. 2021

Polymers for Advanced Techs

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“…Glutathiones is a natural compound that protects cells from oxidative damage and from the toxicity of xenobiotic electrophiles but may also enhance the intracellular reduction of Pt(IV) prodrugs into the corresponding Pt(II) active form. GSH concentrations in intracellular and extracellular environments have been found to range between 2–10 mM and 2–20 μM, respectively [ 48 , 49 , 50 ]. However, in our case, the more relevant value was that of GSH levels in the brain, reported to be 1–2 mM in normal conditions [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

et al. 2022

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Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by coordination chemistry, we engineered nanoparticles by reaction of a platinum (IV) prodrug and iron metal ions showing in vitro dual pH- and redox-sensitivity, controlled release and comparable cytotoxicity to cisplatin against HeLa and GL261 cells. In vivo intranasal administration in orthotopic preclinical GL261 glioblastoma tumor-bearing mice demonstrated increased accumulation of platinum in tumors, leading in some cases to complete cure and prolonged survival of the tested cohort. This was corroborated by a magnetic resonance imaging follow-up, thus opening new opportunities for intranasal glioblastoma therapies while minimizing side effects. The findings derived from this research showed the potentiality of this approach as a novel therapy for glioblastoma treatment.

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“…Moreover, solid tumors have elevated levels of glutathione (GSH), which can also be exploited to trigger the release of anticancer drugs [ 32 , 33 , 34 , 35 ]. In this regard, the disulfide bonds within the nanoparticles can be cleaved in the presence of GSH, enhancing the release of the drug [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Albumin-Based Nanoparticles for the Delivery of Doxorubicin in Breast Cancer

Prajapati

García-Garrido

Somoza

2021

Cancers

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Albumin-based nanoparticles are an emerging platform for the delivery of various chemotherapeutics because of their biocompatibility, safety, and ease of surface modification for specific targeting. The most widely used method for the preparation of albumin nanoparticles is by desolvation process using glutaraldehyde (GLU) as a cross-linker. However, limitations of GLU like toxicity and interaction with drugs force the need for alternative cross-linkers. In the present study, several cross-linking systems were evaluated for the preparation of Bovine Serum Albumin (BSA) nanoparticles (ABNs) encapsulating Doxorubicin (Dox). Based on the results obtained from morphological characterization, in vitro release, and therapeutic efficacy in cells, N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)-modified ABNs (ABN-SPDP) was chosen. Since ABN-SPDP are formed with disulfide linkage, the drug release is facilitated under a highly reducing environment present in the tumor sites. The cytotoxicity studies of those ABN-SPDP were performed in three different breast cell lines, highlighting the mechanism of cell death. The Dox-encapsulated ABN-SPDP showed toxicity in both the breast cancer cells (MCF-7 and MDA-MB-231), but, remarkably, a negligible effect was observed in non-tumoral MCF-10A cells. In addition to the hydrophilic Dox, this system could be used as a carrier for hydrophobic drugs like SN38. The system could be employed for the preparation of nanoparticles based on human serum albumin (HSA), which further enhances the feasibility of this system for clinical use. Hence, the albumin nanoparticles developed herein present an excellent potential for delivering various drugs in cancer therapy.

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Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles

Cited by 14 publications

References 66 publications

Fabrication and characterization of glutathione‐responsive nanoparticles from the disulfide bond‐bridged block copolymer

Fabrication and characterization of glutathione‐responsive nanoparticles from the disulfide bond‐bridged block copolymer

Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

Albumin-Based Nanoparticles for the Delivery of Doxorubicin in Breast Cancer

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