Enhanced endocytosis elevated virulence and severity of SARS-CoV-2 due to hyperglycemia in type 2 diabetic patients

Subbaram, Kannan; Ali, Pyar; Ali, Sheeza

doi:10.1016/j.genrep.2022.101495

Cited by 6 publications

(5 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent data have shown that COVID-19 patients with diabetes had lower lymphocyte counts and higher neutrophil counts compared with COVID-19 patients without diabetes [12]. Upon admission, many patients had a tendency to lymphopenia (1.04) (Table 1), elevated levels of infection-related biomarkers (C-reactive protein (34.5) and procalcitonin (0.8)) and relatively high levels of neutrophils (7.92), alanine aminotransferase (46), total bilirubin (9.7), albumin (36.0), blood urea nitrogen (6), serum creatinine (70), cardiac troponin (0.012) and D-dimer (0.41) (Table 2).…”

Section: Resultsmentioning

confidence: 99%

COVID-19 and diabetes mellitus: Clinical and laboratory features in hospitalized patients

2023

View full text Add to dashboard Cite

Introduction: In December 2019, China first encountered an unknown SARS-CoV-2 virus, after which a global lockdown began, first in European countries, and after a while the virus spread around the world. The course of COVID-19 aggravates the presence of concomitant diseases in the patient, among which diabetes mellitus occupies one of the first places. It should also be noted that the two-way interaction between COVID-19 and diabetes mellitus creates a vicious circle in which COVID-19 leads to worsening of dysglycemia, and diabetes mellitus, in turn, exacerbates the severity of COVID-19. In this article, we evaluated the relationship between diabetes mellitus and the prognosis of COVID-19 in patients of the Shymkent Infectious Diseases Hospital. Aim: Assessment of the relationship of type 2 diabetes mellitus (DM2) with the course and outcomes of COVID-19, depending on clinical and laboratory parameters and concomitant diseases in an infectious hospital in Shymkent. Material and methods: Electronic medical records of groups of COVID-19 patients with diabetes mellitus (DM) (n=49) and without diabetes mellitus (n=151) were analyzed: demographic, clinical, laboratory and instrumental research methods; treatment regimens, complications and outcomes. Results: Compared with patients without diabetes mellitus, patients with diabetes mellitus had a significantly higher incidence of bilateral pneumonia (95.92%). According to complications and clinical outcomes, the incidence of respiratory failure (42% vs. 24%, P=0.022), acute heart failure (51% vs. 18%, P<01) and death (24% vs. 8.0%, P=0.01) in the diabetes group was significantly higher than in the group without diabetes mellitus. In addition, patients with diabetes mellitus had higher levels of neutrophils (P=012), C-reactive protein (P=008), procalcitonin (P<01) and D-dimer (P=032) and lower levels of lymphocytes (P=0.032) and albumin (P=034). Conclusion: Diabetes is a significant risk factor for an unfavorable prognosis of COVID-19. In order to avoid adverse outcomes, more attention should be paid to timely prevention and treatment of patients with diabetes, especially those who need insulin therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

COVID-19 and diabetes mellitus: Clinical and laboratory features in hospitalized patients

2023

View full text Add to dashboard Cite

show abstract

“…This could become more serious especially when Covid-19 strikes and the virus itself has been proved to cause myocarditis (Siripanthong et al, 2020). It is believed that hyperglycaemia in diabetes disease may enhance viral replication, as many studies have revealed that infected cells tend to manipulate glycolytic metabolism to secure virus precursors for production and assembly (Subbaram et al, 2022). In addition, the degree of immune impairment correlates with disease severity (Wang et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Comorbidity Status of Deceased of Covid-19 Patients in Malaysia

Roslan¹,

Ismail²,

Zamzuri³

et al. 2022

IJARBSS

View full text Add to dashboard Cite

There have been 35,737 fatalities and 4,544,626 confirmed cases of Covid-19 in Malaysia as of June 2022. Based on previous study, Covid-19 patients who have comorbidity are likely to have increased risk of fatality. In this regard, the present study is designed to collect preliminary data that prove the potential relationship between comorbidity and Covid-19 fatality in Malaysia. The data was extracted from Covid-19 official website (COVIDNOW) using Microsoft Excel. These comprises of number of deaths, number of cases, age, gender, and country of origin and any coexisting conditions. Results show that among 471 deceased of Covid-19 patients, 22.5% of them had no comorbidity while 77.5% of the mortality had comorbidities. This is led by hypertension as the top one (52.23%), followed by diabetes (36.73 %) and heart disease (15.71 %). This study highlights the potential link between comorbidity status and deceased Covid-19 patients in Malaysia. However, further in-dept research is still necessary to thoroughly understand the link between these two variables. These data signal the importance of proper Covid-19 management among patients with comorbidity.

show abstract

“…In addition, hyperglycemia is associated with stiffer blood vessels, which cause slower circulation and capillary dysfunction, predisposing to reduced tissue oxygenation[ 16 ]. Moreover, hyperglycemia contributes to increased virulence of some pathogens as observed in some coronavirus disease 2019 patients with type 2 diabetes mellitus where an uncontrolled blood glucose level was directly linked to increased severe acute respiratory syndrome coronavirus 2 replication and increased severity of complications[ 17 ]. This is in accordance with multiple studies that confirmed the association of hyperglycemia with increased bacterial load and virulence expression in Staphylococcus aureus ( S. aureus ) and Pseudomonas aeruginosa ( P. aeruginosa ) infections accompanied by increased severity of the infection in diabetic patients[ 18 , 19 ].…”

Section: Factors That Increase the Risk Of Infection In Diabetic Pati...mentioning

confidence: 99%

What’s old is new again: Insights into diabetic foot microbiome

Rajab¹,

Hegazy²

2023

World J Diabetes

View full text Add to dashboard Cite

Diabetes is a chronic disease that is considered one of the most stubborn global health problems that continues to defy the efforts of scientists and physicians. The prevalence of diabetes in the global population continues to grow to alarming levels year after year, causing an increase in the incidence of diabetes complications and health care costs all over the world. One major complication of diabetes is the high susceptibility to infections especially in the lower limbs due to the immunocompromised state of diabetic patients, which is considered a definitive factor in all cases. Diabetic foot infections continue to be one of the most common infections in diabetic patients that are associated with a high risk of serious complications such as bone infection, limb amputations, and life-threatening systemic infections. In this review, we discussed the circumstances associated with the high risk of infection in diabetic patients as well as some of the most commonly isolated pathogens from diabetic foot infections and the related virulence behavior. In addition, we shed light on the different treatment strategies that aim at eradicating the infection.

show abstract

Enhanced endocytosis elevated virulence and severity of SARS-CoV-2 due to hyperglycemia in type 2 diabetic patients

Cited by 6 publications

References 64 publications

COVID-19 and diabetes mellitus: Clinical and laboratory features in hospitalized patients

COVID-19 and diabetes mellitus: Clinical and laboratory features in hospitalized patients

Comorbidity Status of Deceased of Covid-19 Patients in Malaysia

What’s old is new again: Insights into diabetic foot microbiome

Contact Info

Product

Resources

About