Enhanced degradation of chitosan by applying plasma treatment in combination with oxidizing agents for potential use as an anticancer agent

Chokradjaroen, Chayanaphat; Rujiravanit, Ratana; Watthanaphanit, Anyarat; Theeramunkong, Sewan; Saito, Nagahiro; Yamashita, Kikuji; Arakawa, Ryuichi

doi:10.1016/j.carbpol.2017.03.006

Cited by 46 publications

(25 citation statements)

References 55 publications

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“…However, the process is time-consuming, and the cost of handling is relatively high. In recent years, exploring alternative techniques for chitin and chitosan modification, physical methods for the modification of chitin and chitosan, have focused on the utilization of various kinds of energy, [39,41,67,74], hypocholesterolemic effect [75], anti-microbial: gram-positive [76], anti-microbial: gram-negative [76], anti-inflammatory [77], anti-tumor/anti-cancer [39,49,74,78], anti-allergy [79], calcium absorption [80], anti-oxidant [81]).…”

Section: Chitin and Chitosanmentioning

confidence: 99%

Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

Chokradjaroen

Niu

Panomsuwan

et al. 2021

IJMS

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Sustainability and environmental concerns have persuaded researchers to explore renewable materials, such as nature-derived polysaccharides, and add value by changing chemical structures with the aim to possess specific properties, like biological properties. Meanwhile, finding methods and strategies that can lower hazardous chemicals, simplify production steps, reduce time consumption, and acquire high-purified products is an important task that requires attention. To break through these issues, electrical discharging in aqueous solutions at atmospheric pressure and room temperature, referred to as the “solution plasma process”, has been introduced as a novel process for modification of nature-derived polysaccharides like chitin and chitosan. This review reveals insight into the electrical discharge in aqueous solutions and scientific progress on their application in a modification of chitin and chitosan, including degradation and deacetylation. The influencing parameters in the plasma process are intensively explained in order to provide a guideline for the modification of not only chitin and chitosan but also other nature-derived polysaccharides, aiming to address economic aspects and environmental concerns.

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Section: Chitin and Chitosanmentioning

confidence: 99%

Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

Chokradjaroen

Niu

Panomsuwan

et al. 2021

IJMS

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“…The chitosan, specifically the oligosaccharide variants, exhibits anti-cancer activity ( Chokraadjaroen et al, 2017 ; Gibot et al, 2015 ; Oberemko et al, 2019 ; Rafael et al, 2019 ). Its anti-cancer mechanism is generally not known, but it is presumably associated with its electrostatic charges, changes in membrane permeability of cancer cells, regulation of expression of tumor factor such as metalloproteinase-9 and/or vascular endothelial growth factor, and pro-apoptotic effects.…”

Section: Lung Cancer and The Applications Of Chitosan Based Carriersmentioning

confidence: 99%

“…Its anti-cancer mechanism is generally not known, but it is presumably associated with its electrostatic charges, changes in membrane permeability of cancer cells, regulation of expression of tumor factor such as metalloproteinase-9 and/or vascular endothelial growth factor, and pro-apoptotic effects. The significance of positive charges of chitosan in combating cancer growth is reflected by quaternized chitosan derivatives being more selective and potent as a cancer therapeutic than the native chitosan ( Chokraadjaroen et al, 2017 ). The cytotoxic effects of chitosan are characterized by apoptosis via the activation of caspase 3 and caspase 8 ( Almutairi et al, 2019 ; Bharathi et al, 2019 ).…”

Section: Lung Cancer and The Applications Of Chitosan Based Carriersmentioning

confidence: 99%

A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

Rasul

Muniandy

Zakaria

et al. 2020

Carbohydrate Polymers

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“…The plasmachemical processes in non-equilibrium low temperature plasmas are able to substitute mentioned hydrolysis techniques of chitosan modification and derivatization. Gas discharge plasmas and chitosan destruction by a high frequency bipolar pulsed DC (direct current) discharge in liquid-phase plasma systems have been demonstrated in several studies [29][30][31][32][33][34][35][36]. However, the substrates to be processed were thin chitosan films or chitosan solutions, i.e., preliminary preparations of raw chitosan were needed.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Plasma Chemical Processing in Beam-Plasma Reactors as a Way of Environmentally Friendly Phytostimulants Production

et al. 2021

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A novel technique of phytoactive water-soluble chitooligosaccharide (COS) production in low-temperature plasma is described. Design, operation, and control of plasma chemical reactors used to produce COS from the powder of high molecular weight chitosan are presented. The electron beam plasma is strongly non-equilibrium and chemically active; plasma was excited by injecting the scanning electron beam into reaction volume filled with aerosol, containing oxygen and chitosan powder. Plasma chemical processes, responsible for the raw chitosan destruction and techniques of these processes to obtain control of products of optimal molecular weight, are considered. COS, in amounts sufficient for laboratory tests with some plants, were produced. Tests showed that the addition of COS into the liquid growing medium at 0.25 and 1 mg/mL stimulates root growth in Arabidopsis thaliana seedlings (Col-0) by up to 40%, with respect to control plants. Foliar application of these COS formulations at 0.25 mg/mL on tomato plants (cv. Micro-Tom) also resulted in increases between 11.9% and 36% in two important plant productivity indicators (flower and fruit numbers) compared to the control plants. Being environmentally friendly (and resource saving) the electron beam plasma technology of renewable natural biopolymer processing can be considered as a competitive way to produce biostimulants for commercial agriculture.

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Enhanced degradation of chitosan by applying plasma treatment in combination with oxidizing agents for potential use as an anticancer agent

Cited by 46 publications

References 55 publications

Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

Chitosan Plasma Chemical Processing in Beam-Plasma Reactors as a Way of Environmentally Friendly Phytostimulants Production

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