A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

Rasul, Ruhisy Mohd; Muniandy, Moganadass; Zakaria, Zabliza; Shah, Kamal; Chee, Chin Fei; Dabbagh, Ali; Rahman, Noorsaadah Abd.; Wong, Tin Wui

doi:10.1016/j.carbpol.2020.116800

Cited by 91 publications

(42 citation statements)

References 184 publications

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“…The best inhibitory effect was observed for green shell powder against P. aeruginosa (3 µg mL −1 ) and E. coli (410 µg mL −1 ), followed by the blue crab dorsal carapace against S. aureus (760 µg mL −1 ); this is linked to the content of biopolymer chitin, which was previously detected in native crustacean shells by spectroscopic and x-ray diffraction methods [ 4 , 5 , 6 ]. Chitosan is a deacetylated form of chitin, the pharmacological potential of which is well reported in the literature [ 25 , 26 ]. Moreover, a moderate antibacterial (and anti-fungal) capacity of the blue crab and crab and shrimp shell had been previously reported [ 27 , 28 ]; hence the micropowder produced from wasted crab shells is suitable for all fertilizing product categories from the microbiological point of view.…”

Section: Discussionmentioning

confidence: 99%

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

et al. 2021

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The compliance of crab shells traditionally used as a complex natural product for agricultural soil amendment with modern biofertilizers' quality and safety requirements was investigated. Shells waste from the Blue crab, Callinectes sapidus and the Green crab, Carcinus aestuarii were tested for macronutrients, heavy metals, bacteria content, and antimicrobial properties. Such information is crucial for further utilization of the biogenic powders for any composite formulation in added-value by-products. The calcium carbonate-rich hard tissue yield was 52.13% ± 0.015 (mean ± S.D.) and 64.71% ± 0.144 from the blue and green crabs, respectively. The contents of Pb, Ni, Zn, Cr (VI), and Cu were several orders of magnitude below the prescribed limit by EU biofertilizer legislation, with Fe, Mn (not prescribed), and As being the most abundant. The content of As and Cd from the material considered here was within limits. The shells contain no colony-forming units of Salmonella spp. and compliant levels of Escherichia coli; moreover, the shell micro-powder showed dose-dependent growth inhibition of Pseudomonas aeruginosa and Staphylococcus aureus. In summary, the waste crab shells present a complex natural product as plant biofertilizer following the circular economy concepts.

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Section: Discussionmentioning

confidence: 99%

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

et al. 2021

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“…Chitosan plays a substantial role in drug delivery into lung tissue in infectious diseases as it is a biodegradable, biocompatible, and safe polymer. It acts as a pulmonary particulate carrier for drugs because of its mucoadhesive effect and its ability to locate into the specific site, as well as its permeation [ 131 ]. Therefore, combining MSCs with chitosan hydrogel could enhance their therapeutic efficacy, permeation, adhesion, and targeting.…”

Section: Future Approaches To Enhancing Msc Potency For Covid-19 Treatmentmentioning

confidence: 99%

Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects

et al. 2021

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Novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The virus causes an exaggerated immune response, resulting in a cytokine storm and acute respiratory distress syndrome, the leading cause of COVID-19-related mortality and morbidity. So far, no therapies have succeeded in circumventing the exacerbated immune response or cytokine storm associated with COVID-19. Mesenchymal stem cells (MSCs), through their immunomodulatory and regenerative activities, mostly mediated by their paracrine effect and extracellular vesicle production, have therapeutic potential in many autoimmune, inflammatory, and degenerative diseases. In this paper, we review clinical studies on the use of MSCs for COVID-19 treatment, including the salutary effects of MSCs on the pathophysiology of COVID-19 and the immunomodulation of the cytokine storm. Ongoing clinical trial designs, cell sources, dose and administration, and populations are summarized, and the paracrine mode of benefit is discussed. We also offer suggestions for optimizing MSC-based therapies, including genetic engineering, strategies for cell surface modification, nanotechnology applications, and combination therapies.

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“…Due to chitosan possessing many functional groups in its chemical structure it is possible to use this polysaccharide for preparation of carriers for various active substances which may form bonds with the mentioned groups [ 9 ]. Chitosan-based carriers were investigated as systems for delivery of many anticancer [ 10 , 11 , 12 ] and anti-inflammatory drugs [ 13 , 14 ]. Among many applications of chitosan for biomedical purposes, one of the most promising ones seems to be its use for preparation of modern wound dressing materials [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Starch Solutions Prepared under Different Conditions as Modifiers of Chitosan/Poly(aspartic acid)-Based Hydrogels

et al. 2021

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Recently, there has been great interest in the application of polysaccharides in the preparation of diverse biomaterials which result from their biocompatibility, biodegradability and biological activity. In this work, the investigations on chitosan/poly(aspartic acid)-based hydrogels modified with starch were described. Firstly, a series of hydrogel matrices was prepared and investigated to characterize their swelling properties, structure via FT-IR spectroscopy, elasticity and tensile strength using the Brookfield texture analyzer as well as their impact on simulated physiological liquids. Hydrogels consisting of chitosan and poly(aspartic acid) in a 2:1 volume ratio were elastic (9% elongation), did not degrade after 30-day incubation in simulated physiological liquids, exhibited a relative biocompatibility towards these liquids and similar swelling in each absorbed medium. This hydrogel matrix was modified with starch wherein two of its form were applied—a solution obtained at an elevated temperature and a suspension obtained at room temperature. Hydrogels modified with hot starch solution showed higher sorption that unmodified materials. This was probably due to the higher starch inclusion (i.e., a larger number of hydrophilic groups able to interact with the adsorbed liquid) when this polysaccharide was given in the form of a hot solution. Hydrogels modified with a cold starch suspension had visible heterogeneous inequalities on their surfaces and this modification led to the obtainment materials with unrepeatable structures which made the analysis of their properties difficult and may have led to misleading conclusions.

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A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

Abstract: Graphical abstract

Cited by 91 publications

References 184 publications

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects

Starch Solutions Prepared under Different Conditions as Modifiers of Chitosan/Poly(aspartic acid)-Based Hydrogels

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