Enhanced chemotherapeutic toxicity of cyclodextrin templated size-tunable rhodamine 6G nanoGUMBOS

Bhattarai, Nimisha; Chen, Mi; Pérez, Rocío L.; Ravula, Sudhir; Chhotaray, Pratap K.; Hamdan, Suzana; McDonough, Karen C.; Tiwari, Swati; Warner, Isiah M.

doi:10.1039/c8tb01115j

Cited by 14 publications

(12 citation statements)

References 42 publications

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“…1A) by ionassociation. [79][80][81][82][83][84][85] For this, we mixed TPE-DPA-Py iodide (2 μM) with a 10-fold molar excess of the corresponding counterions in water. Dynamic light scattering (DLS) measurements showed that TPE-DPA-Py iodide in the presence of counterions forms relatively small particles ranging from ca.…”

Section: Resultsmentioning

confidence: 99%

“…The observed 50 nm red shift for AIEgen with bulky counterions is probably related to much larger dimeter of TPE-F5 and TPE-F12, 1.16 and 1.60 nm, respectively, in comparison to PF6 and ClO4, 0.33 and 0.35 nm, respectively, which can induce larger dye-dye distance in case of bulky counterions. It should be noted that the dye salts with these counterions are amorphous materials, sometimes called as frozen ionic liquids, 80,83,84 which do not allow X-ray crystallography. Therefore, better understanding of the counterion effect will require a dedicated theoretical study.…”

Section: Aie Behaviour Of Tpe-dpa-py With Different Counterionsmentioning

confidence: 99%

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Ionic aggregation-induced emission dye with bulky counterions for preparation of bright near-infrared polymeric nanoparticles

Adarsh

Klymchenko

2019

Nanoscale

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Section: Resultsmentioning

confidence: 99%

Section: Aie Behaviour Of Tpe-dpa-py With Different Counterionsmentioning

confidence: 99%

Ionic aggregation-induced emission dye with bulky counterions for preparation of bright near-infrared polymeric nanoparticles

Adarsh

Klymchenko

2019

Nanoscale

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“…The size of nano drugs has a great influence on the therapeutic efficiency. N. Bhattarai et al [122] . studied the effect of nano‐size rhodamine‐based nanoGUMBOS in chemotherapy using three templating systems such as 2HP‐α‐, 2HP‐β‐, and γ‐CD (cyclodextrin).…”

Section: Synthesis and Applications Of Nanogumbosmentioning

confidence: 99%

“…The hydrophobicity of synthesized nanomaterials was tuned with different anions and followed the order of: The size of nano drugs has a great influence on the therapeutic efficiency. N. Bhattarai et al [122] studied the effect of nano-size rhodamine-based nanoGUMBOS in chemotherapy using three templating systems such as 2HP-α-, 2HP-β-, and γ-CD (cyclodextrin). Firstly, GUMBOS was synthesized by anionexchange reaction among salts, followed by the formation of nanoparticles using an ultrasonication approach in the absence/presence of different templates (Table 3, Entry 3-8).…”

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confidence: 99%

Recent Progress in Synthesis and Applications of Tunable Materials and Nanomaterials Based on Organic Salts

Kaur

Chopra

2020

ChemistrySelect

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GUMBOS (group of uniform materials based on organic salts) are a new class of solid organic ionic materials that shared similar properties as that of ionic liquids, but have a wider range of melting points from 25°C to 250°C. A large number of combinations have been made to design and synthesize multifunctional GUMBOS with tuned properties that are encouraged to explore these organic materials for various applications. Further, nanomaterials can be fabricated from GUMBOS through various reliable synthetic approaches. These nanomaterials have known as ‚nanoGUMBOS' that possessed advantageous properties at the nanoscale and can be used for target applications. Besides, the size, shape, and uniformity of nanomaterials can be tuned by varying different experimental parameters, and synthetic routes. This review is divided into two parts and presents all the published data regarding GUMBOS and nanoGUMBOS. The first part enclosed the synthesis of GUMBOS as well as their potential applications in the field of analytical, optoelectronics, biology, and sensor technology. In the second part, the synthesis of nanoGUMBOS using different methods and their applications in the field of cellular imaging, optoelectronics, catalysis, enantiorecognition, and sensor technology will be highlighted.

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“…In fact, the literature on development of novel methodologies based on use of ionic liquids (ILs), a group of uniform materials based on organic salts (GUMBOS), and nanoGUMBOS is increasing at an ever-expanding rate. For example, numerous studies from the literature can be cited for utility of such materials in diverse areas such as antibiotics [13][14][15], cancer therapy [16][17][18][19][20][21][22][23][24], hydrogels [25,26], cellular imaging [27,28], chirality [29][30][31][32][33], dye-sensitized solar cells (DSSCs) [34][35][36], extractions [37][38][39], gel electrophoresis [40,41], detection of reactive oxygen species [42], liquid crystals [43], mass spectrometry [44], nanomaterials [45][46][47][48][49][50][51][52], optoelectronics [53][54][55][56], sensors [57]…”

Section: Introductionmentioning

confidence: 99%

Group of Uniform Materials Based on Organic Salts (GUMBOS): A Review of Their Solid State Properties and Applications

Pérez¹,

Ayala²,

Warner³

2021

Ionic Liquids - Thermophysical Properties and Applications

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Ionic liquids (ILs) are defined as organic salts with melting points below 100 °C. Such ionic compounds are typically formed using bulky cations and/or bulky anions in order to produce liquids or lower melting solids. ILs have been widely explored in several research areas including catalysis, remediation, solvents, separations, and many others. The utility of such compounds has also been recently broadened to include solid phase ionic materials. Thus, researchers have pushed the boundaries of ILs chemistry toward the solid state and have hypothesized that valuable properties of ILs can be preserved and fine-tuned to achieve comparable properties in the solid state. In addition, as with ILs, tunability of these solid-phase materials can be achieved through simple counterion metathesis reactions. These solid-state forms of ILs have been designated as a group of uniform materials based on organic salts (GUMBOS). In contrast to ILs, these materials have an expanded melting point range of 25 to 250 °C. In this chapter, we focus on recent developments and studies from the literature that provide for fine tuning and enhancing properties through transformation and recycling of diverse ionic compounds such as dyes, antibiotics, and others into solid state ionic materials of greater utility.

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Enhanced chemotherapeutic toxicity of cyclodextrin templated size-tunable rhodamine 6G nanoGUMBOS

Abstract: Rhodamine 6G nanoGUMBOS were templated with cyclodextrin to develop size tunable nanodrugs with enhanced cellular uptake and selective chemotherapeutic toxicity.

Cited by 14 publications

References 42 publications

Ionic aggregation-induced emission dye with bulky counterions for preparation of bright near-infrared polymeric nanoparticles

Ionic aggregation-induced emission dye with bulky counterions for preparation of bright near-infrared polymeric nanoparticles

Recent Progress in Synthesis and Applications of Tunable Materials and Nanomaterials Based on Organic Salts

Group of Uniform Materials Based on Organic Salts (GUMBOS): A Review of Their Solid State Properties and Applications

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